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(Current opinion in organ transplantation[TA])
972 results
  • Mesenchymal stromal cells for immunoregulation after liver transplantation: the scene in 2016. [Journal Article]
  • COCurr Opin Organ Transplant 2016 Oct 7
  • Johnson CL, Soeder Y, Dahlke MH
  • CONCLUSIONS: Eagerly awaited results from the second generation of solid organ transplantation clinical trials, many of which are nearing completion, will perhaps establish the effectiveness of combining MSCs and low-dose pharmacological immunosuppression in promoting graft acceptance. At present, the question of whether infusional cell products based on MSCs will have a significant clinical impact in the field of liver transplantation remains open.
  • Emerging advancements in liver regeneration and organogenesis as tools for liver replacement. [Journal Article]
  • COCurr Opin Organ Transplant 2016 Oct 15
  • Huppert SS, Campbell KM
  • CONCLUSIONS: Although mature hepatocytes have the potential to bridge to, or replace whole organ transplantation, limits in the ability to obtain healthy cells, stabilize in-vitro expansion, cryopreserve, and alleviate rejection, still exist. Alternative sources for generating hepatocytes hold promise for cell therapy and tissue engineering. These may allow generation of autologous or universal donor cells that eliminate the need for immunosuppression; however, limits exist regarding hepatocyte maturity and efficacy at liver repopulation, as well as applicability to human chronic liver disease.
  • Mesenchymal stromal cells in clinical kidney transplantation: how tolerant can it be? [Journal Article]
  • COCurr Opin Organ Transplant 2016 Oct 15
  • van Kooten C, Rabelink TJ, … Reinders ME
  • CONCLUSIONS: This review will discuss the current status of ongoing clinical trials with mesenchymal stromal cells in kidney transplantation and specifically concentrate on the possibilities and impossibilities of how these therapeutic strategies can contribute to control of the different forms of alloreactivity operation in organ transplantation.
  • Improving cardiac reprogramming for heart regeneration. [Journal Article]
  • COCurr Opin Organ Transplant 2016 Oct 15
  • Liu L, Lei I, Wang Z
  • CONCLUSIONS: Novel strategies for highly efficient iCM reprogramming will be required for applying iCM reprogramming to patients. Creative and combined methods based on our understanding of cardiogenesis will continue to contribute heavily in the advancement of iCM reprogramming. We are highly optimistic that iCM reprogramming-based heart therapy will restore the pumping function of damaged patient hearts.
  • Long-term effects of islet transplantation. [Journal Article]
  • COCurr Opin Organ Transplant 2016; 21(5):497-502
  • Holmes-Walker DJ, Kay TW
  • CONCLUSIONS: Reversal of hypoglycemia unawareness and protection from severe hypoglycemia events are two of the main benefits of islet transplantation and they persist for the duration of graft function. Islet transplantation compares favorably with other therapies for those with hypoglycemia unawareness, although new technologies have not been tested head-to-head with transplantation. HLA sensitization increases with time after transplantation especially if immunosuppression is ceased and is a risk for those who may require future transplantation as well as being associated with loss of graft function.
  • Development and refinement of computer-assisted planning and execution system for use in face-jaw-teeth transplantation to improve skeletal and dento-occlusal outcomes. [Journal Article]
  • COCurr Opin Organ Transplant 2016; 21(5):523-9
  • Hashemi S, Armand M, Gordon CR
  • CONCLUSIONS: A comprehensive CAPE system for use in FJTT was developed through a multicenter collaboration and refined using plastic models, live miniature swine surgery, and human cadaver models. The system marries preoperative surgical planning and intraoperative execution by allowing on-table navigation of the donor fragment relative to recipient cranium, and real-time reporting of patient's cephalometric measurements relative to a desired dental-skeletal outcome. FJTTs using live-animal and cadaveric models demonstrate the CAPE system to be accurate in navigation and beneficial in improving hybrid occlusion and other craniofacial outcomes. Future refinement of the CAPE system includes integration of more commonly performed orthognathic/maxillofacial procedures.
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