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(Drug Dev Ind Pharm[TA])
3,128 results
  • Improved stability of solid dispersions of manidipine with polyethylene glycol 4000/copovidone blends: application of ternary phase diagram. [Journal Article]
  • DDDrug Dev Ind Pharm 2016 Dec 07; :1-9
  • Chamsai B, Limmatvapirat S, … Sriamornsak P
  • CONCLUSIONS: The results showed that MDP was molecularly dispersed in PEG4000 and copovidone when the tSD was created from homogeneous region of solid ternary phase diagram. FTIR results confirmed that strong hydrogen bonding was presented between MDP and copovidone, leading to a significant increase in the solubility and dissolution of MDP. After storage at accelerated condition (40 °C/75%RH) for 6 months, the tSD still showed a good appearance and high solubility.The results of this study suggest that tSD prepared by melting has promising potential for oral administration and may be an efficacious approach for improving the therapeutic potential of MDP.
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