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(Drug Dev Ind Pharm[TA])
3,109 results
  • The performance of HPMC matrix tablets using various agglomeration manufacturing processes. [Journal Article]
  • DDDrug Dev Ind Pharm 2016 Oct 14; :1-32
  • Košir D, Vrečer F
  • CONCLUSIONS: Compression mixtures made using the wet-granulation method exhibit better flow and compression properties than compression mixtures made using the dry-granulation method. The direct compression method proved to be the least appropriate manufacturing method because the compression mixture has very poor flow and the lowest compressibility/compactibility index. The choice of granulation technique significantly influences the swelling behavior and drug-dissolution profile of the final matrix tablets, also resulting in dissimilar release profiles. The choice of granulation method has the greatest influence on the drug-release profile. The direct compression method provides tablets with the fastest drug-release profile, followed by the dry-granulation and wet-granulation methods. The particle size of granules and porosity of tablets play an important role, contributing to differences in drug-release profiles.
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