(Ophthalmic research[TA]) articles in PubMed
- Evaluation of the Narrow Anterior Chamber Angle by Anterior Segment Optical Coherence Tomography. [Journal Article]
- Ophthalmic Res 2016 Sep 15OR
- CONCLUSIONS: ITC was common in eyes with a shallow peripheral anterior chamber (superiorly, gonioscopic grade 0). Sites with wider gonioscopic grading tended to have a larger T-I angle. Axial length and refraction significantly impacted on the frequency of ITC.
- Photoreceptor Integrity Predicts Response to Anti-VEGF Treatment. [Journal Article]
- Ophthalmic Res 2016 Sep 15OR
- CONCLUSIONS: Recovery of FPM after anti-VEGF treatment was significantly associated with a VA improvement. Direct measurement of photoreceptor integrity might provide an additional tool for the assessment of retinal function and treatment response in patients newly diagnosed with ME.
- Modeling Human Glaucoma: Lessons from the in vitro Models. [Journal Article]
- Ophthalmic Res 2016 Sep 13OR
- Glaucoma, a leading cause of blindness worldwide, is a degenerative disease characterized by retinal ganglion cell (RGC) loss and optic nerve atrophy. Elevated intraocular pressure (IOP) is a main ri...
Glaucoma, a leading cause of blindness worldwide, is a degenerative disease characterized by retinal ganglion cell (RGC) loss and optic nerve atrophy. Elevated intraocular pressure (IOP) is a main risk factor for onset and progression of the disease. Since increased IOP is the only modifiable risk factor, relevant models for glaucoma would comprise RGC and optic nerve damage triggered by ocular hypertension. Animal models of glaucoma have greatly contributed to the understanding of the molecular mechanisms of this pathology, and they have also facilitated the development of new pharmacological interventions. Although animal models of glaucoma have provided valuable information about the disease, there is still no ideal model for studying glaucoma due to its complexity. There is a recognized demand for in vitro models that can replace or reduce the need for animal experiments. Several in vitro models have emerged as a great opportunity in the field of glaucoma research, helping to clarify the mechanisms involved in disease progression. Several types of equipment have been developed to expose cells and tissue cultures to elevated pressures. Herein, we discuss the methodology used to increase pressure, the main findings, and the relevance of in vitro models for the study of the pathophysiology of glaucoma.
- High-Mobility Group Box-1 Protein Mediates the Regulation of Signal Transducer and Activator of Transcription-3 in the Diabetic Retina and in Human Retinal Müller Cells. [Journal Article]
- Ophthalmic Res 2016 Aug 25OR
- CONCLUSIONS: The results suggest a role for HMGB1 in the modulation of STAT-3 expression in the diabetic retina.
- The Suppression of Kallistatin on High-Glucose-Induced Proliferation of Retinal Endothelial Cells in Diabetic Retinopathy. [Journal Article]
- Ophthalmic Res 2016 Aug 19OR
- CONCLUSIONS: Our data indicated that kallistatin might be a potent inhibitory factor for PDR. The molecule plays its role by inhibiting high-glucose-induced proliferation of HRECs. The findings suggest that the upregulation of kallistatin might be an effective strategy for PDR prevention.
- Plasmin Enzyme-Assisted Vitrectomy in Pediatric Patients with Vitreoretinal Diseases. [Journal Article]
- Ophthalmic Res 2016 Aug 6OR
- CONCLUSIONS: Plasmin-assisted vitrectomy offers an effective and less traumatic intervention for a variety of pediatric vitreoretinal diseases.
- Funduscopic versus HRT III Confocal Scanner Vertical Cup-Disc Ratio Assessment in Normal Tension and Primary Open Angle Glaucoma (The Leuven Eye Study). [Journal Article]
- Ophthalmic Res 2016 Aug 4OR
- CONCLUSIONS: Funduscopic and confocal scanner estimates of VCDR differ significantly and should not be used interchangeably. In POAG patients with severe glaucoma, a subjective VCDR predicts functional glaucomatous damage significantly better.
- EVICR.net Activities - Update. [Journal Article]
- Ophthalmic Res 2016; 56(3):163-8OR
- Preoperative Biometric Parameters Predict the Vault after ICL Implantation: A Retrospective Clinical Study. [Journal Article]
- Ophthalmic Res 2016 Jul 28OR
- CONCLUSIONS: Biometric parameters of the anterior segment (ACA, WTW and Lenscur) can predict the vault after ICL implantation using a new regression equation.
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- The Portuguese Experience with Ocriplasmin in Clinical Practice. [Journal Article]
- Ophthalmic Res 2016 Jul 20OR
- CONCLUSIONS: VMT release and FTMH closure were achieved in more than half of the treated eyes and were correlated with significant BCVA improvements and favorable baseline characteristics. In fact, if a careful patient selection is carried out, VMT resolution with ocriplasmin can be optimized, tailoring the best approach to each patient.