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(Radiol Technol[TA])
2,758 results
  • Radiation Therapy Plus Anti-Programmed Death Ligand 1 Immunotherapy: A Review on Overall Survival. [Journal Article]
  • RTRadiol Technol 2016; 88(1):123-8
  • Krcik EM
  • CONCLUSIONS: Low doses of radiation enhance the immune system by increasing T-cell activity. Radiation also increases levels of PD-L1 that inhibit tumor-fighting capabilities of T-cells. Anti-PD-L1 immunotherapy given in combination with radiation therapy has been tested in preclinical studies and hypothesized to increase PFS and OS in patients with advanced melanoma and metastatic NSCLC.Anti-PD-L1 immunotherapy boosts the immune effects of radiation therapy on tumor regression by eradicating the limiting effects of PD-L1 on the immune system. The combination therapies have the potential to benefit metastatic patients who qualify for the treatment.
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