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Rheum Dis Clin North Am [journal]
- Preface. [Editorial]
- Rheum Dis Clin North Am 2014 Feb; 40(1):xi-xii.
- Foreword. [Editorial]
- Rheum Dis Clin North Am 2014 Feb; 40(1):ix.
- Gout and the heart. [Journal Article]
- Rheum Dis Clin North Am 2014 Feb; 40(1):125-43.
The association between gout and cardiovascular diseases has been noted for centuries but was not subjected to rigorous epidemiologic studies until recently. The published literature is almost unanimous in the strength and consistency of this association. However, the impact of gout over and above that conferred by hyperuricemia and other risk factors of cardiovascular disease has not been well studied. Future studies are expected to shed light on the pathophysiologic basis of this association.
- Pulmonary arterial hypertension related to connective tissue disease: a review. [Journal Article]
- Rheum Dis Clin North Am 2014 Feb; 40(1):103-24.
Associated pulmonary arterial hypertension related to connective tissue disorders carries significant morbidity and a high mortality. The purpose of this review article is to present an updated account of the pathogenesis, epidemiology, clinical signs and symptoms, diagnostic modalities, treatment regimens, and prognosis of this disorder.
- Systemic sclerosis and the heart. [Journal Article]
- Rheum Dis Clin North Am 2014 Feb; 40(1):87-102.
Heart disease, either clinically apparent or silent, is a frequent complication of systemic sclerosis (SSc, scleroderma) and may affect both patients with diffuse cutaneous and limited cutaneous SSc. The availability of more sensitive modalities has led to an increased awareness of scleroderma heart disease, which often involves the pericardium, myocardium, and cardiac conduction system. This awareness of cardiac involvement requires attention and interventions led by internists, cardiologists, and rheumatologists. Although no specific therapy exists for scleroderma heart disease, early recognition of the presence and type of scleroderma heart disease may lead to more effective management of patients with scleroderma.
- The heart and pediatric rheumatology. [Journal Article]
- Rheum Dis Clin North Am 2014 Feb; 40(1):61-85.
Recent advances in Kawasaki disease have included attempts to define genes involved in its pathogenesis. There have been recent advances in the studies of rheumatic carditis, leading to a better understanding of the mechanism of the disease. Histologic evaluation of patients with neonatal lupus erythematosus has revealed fibrosis with collagen deposition and calcification of the atrioventricular node. Therapy for cardiac involvement in systemic juvenile idiopathic arthritis should involve treatment of the underlying disease and systemic inflammatory state, and typically includes nonsteroidal antiinflammatory drugs, corticosteroids, disease-modifying drugs, and biologic therapies targeting tumor necrosis factor-alpha, interleukin-1, and interleukin-6.
- Cardiac manifestations of systemic lupus erythematosus. [Journal Article]
- Rheum Dis Clin North Am 2014 Feb; 40(1):51-60.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that manifests with multiorgan inflammation. Cardiac involvement is common, with manifestation that include pericarditis, myocarditis, conduction defects, valvular disease, and coronary artery disease. In addition to cardiac disease in adults with SLE, the children of women with SLE can develop neonatal lupus by passive transfer of autoantibodies across the placenta. This article describes the cardiac manifestations of SLE and highlights some key unanswered questions about the disease and its pathogenesis.
- Cardiovascular disease in rheumatoid arthritis. [Journal Article]
- Rheum Dis Clin North Am 2014 Feb; 40(1):27-49.
Cardiovascular disease causes significant morbidity and mortality in rheumatoid arthritis (RA). Accelerated atherosclerosis caused by inflammation is the hallmark of cardiovascular disease in RA. Cardiac involvement as an extra-articular manifestation of RA is also prevalent but often subclinical. Treatment of RA also has implications on cardiovascular outcomes in RA. In this article, atherosclerotic and nonatherosclerotic cardiac manifestations in RA are discussed, with a focus on pathogenesis and management.
- The heart in vasculitis. [Journal Article]
- Rheum Dis Clin North Am 2014 Feb; 40(1):11-26.
Any cardiac tissue can be affected in most primary vasculitides. However, certain entities such as eosinophilic granulomatosis with polyangiitis (or Churg-Strauss syndrome) and Takayasu arteritis involve the heart in up to 60% of patients. Vasculitic cardiac complications are important to recognize because they have been linked to increased mortality and impact the treatment decision-making process. This article reviews the spectrum of cardiac manifestations in adults with large-, medium-, and small-vessel primary systemic vasculitides as well as their diagnosis and treatment.
- The heart in inflammatory myopathies. [Journal Article]
- Rheum Dis Clin North Am 2014 Feb; 40(1):1-10.
Cardiac involvement in the idiopathic inflammatory myopathies (IIM) has been reported in 5% to 70% of cases. It is estimated that between 15% and 55% of deaths are related to heart disease in patients with dermatomyositis (DM) and polymyositis (PM). Increased atherosclerotic disease in IIM patients has also been reported and is associated with traditional risk factors such as hypertension and dyslipidemia. In the current article we review some of the more recent literature on clinical manifestations and outcomes of cardiovascular disease in IIM patients.