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Rinsho Shinkeigaku [journal]
- Notice for members. [Journal Article]
- Rinsho Shinkeigaku 2013; 53(5):announce5.
- Editor's Note. [Journal Article]
- Rinsho Shinkeigaku 2013; 53(5):417.
- The proceedings of the 200th kyusyu regional meeting of the Japanese society of neurology. [Journal Article]
- Rinsho Shinkeigaku 2013; 53(5):393-403.
- The proceedings of the 93rd chugoku-shikoku regional meeting of the Japanese society of neurology. [Journal Article]
- Rinsho Shinkeigaku 2013; 53(5):383-92.
- Erratum: Current status of the predictive genetic testing for hereditary neurological diseases in Shinshu University Hospital. [Journal Article]
- Rinsho Shinkeigaku 2013; 53(5):382.
- A case of acute ophthalmoparesis with gaze nystagmus. [Journal Article]
- Rinsho Shinkeigaku 2013; 53(5):381.
- Various ocular symptoms in acute ophthalmoplegia. [Journal Article]
- Rinsho Shinkeigaku 2013; 53(5):380.
- A case of Tolosa-Hunt syndrome presenting ocular neuromyotonia. [Journal Article]
- Rinsho Shinkeigaku 2013; 53(5):376-9.
A 27-year-old woman noticed diplopia when gazing left and paresthesia of the left face and headache of the left side for 8 months. Abduction and supraduction of the left eye were moderately restricted. Hypoesthesia of the face innervated by the ophthalmic branch of the left trigeminal nerve was detected. Visual disturbance due to optic neuropathy developed 5 months later. MRI with gadolinium revealed a mass lesion extending from the left cavernous sinus to the orbital apex. Ocular neuromyotonia and corresponding diplopia were induced by sustained right gaze. Such episodes occurred almost every day on awaking in the morning. Prednisolone (60 mg/day) was given and the headache and visual disturbance ameliorated in two days. The diplopia disappeared in 4 days. The patient remains free from these symptoms after 6 months. This is the first report of ocular neuromyotonia associated with Tolosa-Hunt syndrome.
- A case of thymoma-associated myasthenia gravis with anti-MuSK antibodies. [Journal Article]
- Rinsho Shinkeigaku 2013; 53(5):372-5.
We report a 60-year-old male with thymoma-associated myasthenia gravis with anti-MuSK antibodies. In October 2010, he had diplopia, ptosis, and dysphagia. He was diagnosed to have MG in February 2011. The neurological examination disclosed external ophthalmoplegia, bilateral ptosis, mild dysphagia, and fatigability. Repetitive nerve stimulation of the right facial nerve showed CMAP decrement greater than 10%. Patients showed an improvement in ptosis after administration of edrophonium.Anti-acetylcholine receptor antibody was negative, and anti-muscle specific receptor tyrosine kinase antibody was 66.8 nmol/l (cut-off value: 0.05 nmol/l). Prednisolone (50 mg every other day) were started. Contrast-enhanced chest MRI showed a mediastinal mass suggestive of thymoma. Extended thymectomy was performed in March 2011. Histological examination disclosed a type B1 thymoma. After resection of the tumor, the symptoms of MG improved with prednisolone (100 mg every other day). This is a rare case of MG with anti-MuSK antibodies and thymoma, which has been reported previously only in 2 cases.
- A case of meningeal disseminated sarcoidosis with marked hypoglycorrhachia in the CSF. [Journal Article]
- Rinsho Shinkeigaku 2013; 53(5):367-71.
A 29-year-old man diagnosed as having pulmonary sarcoidosis in 2008, and hypothyroidism secondary to thyroidectomy for Basedow's disease was admitted to our hospital with pustular psoriasis in November 2010. He experienced high fever (38°C) and headache in late October 2010. Gadolinium-enhanced T1-weighted image showed multiple micronodular lesions with leptomeningeal enhancement, mainly in the brainstem. Cerebrospinal fluid (CSF) analysis revealed pleocytosis, raised protein level and hypoglycorrhachia (7 mg/dl). The patient was also found to have osteonecrosis of the left femoral head. Antituberculous treatment and steroid pulse therapy were started, but produced no improvement of either the symptoms or the laboratory data. Finally, the patient was diagnosed as having meningeal disseminated sarcoidosis by meningeal biopsy in late March 2011. He was started on treatment with 60 mg prednisolone per day, which resulted in marked clinical improvement. It should be borne in mind that marked hypoglycorrhachia in the CSF can also be seen in meningeal disseminated sarcoidosis.