(Theoretical biology medical modelling[TA]) articles in PubMed
- Erratum to: 'Comparison of calculated and experimental power in maximal lactate-steady state during cycling'. [PUBLISHED ERRATUM]
- Theor Biol Med Model 2016; 13(1):18TB
- Feed-forward neural network model for hunger and satiety related VAS score prediction. [Journal Article]
- Theor Biol Med Model 2016; 13(1):17TB
- CONCLUSIONS: From this application of artificial neural networks, one may conclude that neural network models are very suitable to describe situations where behavior is complex and incompletely understood. However, training data sets that fit the experimental conditions need to be available.
- Long range physical cell-to-cell signalling via mitochondria inside membrane nanotubes: a hypothesis. [Review]
- Theor Biol Med Model 2016; 13(1):16TB
- Coordinated interaction of single cells by cell-to-cell communication (signalling) enables complex behaviour necessary for the functioning of multicellular organisms. A quite newly discovered cell-to...
Coordinated interaction of single cells by cell-to-cell communication (signalling) enables complex behaviour necessary for the functioning of multicellular organisms. A quite newly discovered cell-to-cell signalling mechanism relies on nanotubular cell-co-cell connections, termed "membrane nanotubes" (MNTs). The present paper presents the hypothesis that mitochondria inside MNTs can form a connected structure (mitochondrial network) which enables the exchange of energy and signals between cells. It is proposed that two modes of energy and signal transmission may occur: electrical/electrochemical and electromagnetic (optical). Experimental work supporting the hypothesis is reviewed, and suggestions for future research regarding the discussed topic are given.
- Application of the backstepping method to the prediction of increase or decrease of infected population. [Journal Article]
- Theor Biol Med Model 2016; 13(1):15TB
- CONCLUSIONS: Our prediction method based on the backstepping method can be simplified to the comparison of the numbers of reported cases of the current and previous time steps. In spite of its simplicity, it can provide a good prediction for the spread of influenza in Japan.
- Epidemic cycling in a multi-strain SIRS epidemic network model. [Journal Article]
- Theor Biol Med Model 2016; 13:14TB
- CONCLUSIONS: Our results suggest that co-circulation of multiple strains within a contact network provides an explanation for epidemic cycling.
- Random walk of passive tracers among randomly moving obstacles. [Journal Article]
- Theor Biol Med Model 2016; 13:13TB
- CONCLUSIONS: The results reported here suggest that if a biomolecule, let us call it a test molecule, moves towards its target in the presence of other independently interacting molecules, its motion can be considerably slowed down.
- Assessing potential countermeasures against the dengue epidemic in non-tropical urban cities. [Journal Article]
- Theor Biol Med Model 2016; 13:12TB
- CONCLUSIONS: Measures 2-5 are more or less effective. However, Measure 1 can have the opposite effect, depending on the mobility rates. The restricted movement results in the formation of a kind of core population, which can promote the epidemic in the entire population.
- The organelle of differentiation in embryos: the cell state splitter. [Review]
- Theor Biol Med Model 2016; 13:11TB
- The cell state splitter is a membraneless organelle at the apical end of each epithelial cell in a developing embryo. It consists of a microfilament ring and an intermediate filament ring subtending ...
The cell state splitter is a membraneless organelle at the apical end of each epithelial cell in a developing embryo. It consists of a microfilament ring and an intermediate filament ring subtending a microtubule mat. The microtubules and microfilament ring are in mechanical opposition as in a tensegrity structure. The cell state splitter is bistable, perturbations causing it to contract or expand radially. The intermediate filament ring provides metastability against small perturbations. Once this snap-through organelle is triggered, it initiates signal transduction to the nucleus, which changes gene expression in one of two readied manners, causing its cell to undergo a step of determination and subsequent differentiation. The cell state splitter also triggers the cell state splitters of adjacent cells to respond, resulting in a differentiation wave. Embryogenesis may be represented then as a bifurcating differentiation tree, each edge representing one cell type. In combination with the differentiation waves they propagate, cell state splitters explain the spatiotemporal course of differentiation in the developing embryo. This review is excerpted from and elaborates on "Embryogenesis Explained" (World Scientific Publishing, Singapore, 2016).
- Modeling immune response and its effect on infectious disease outbreak dynamics. [Journal Article]
- Theor Biol Med Model 2016; 13:10TB
- CONCLUSIONS: Our results suggest that it is essential for the public health establishment to increase their understanding of the characteristics of regional demographics that could impact the quality of the immune response of the individuals. The results indicate that it is necessary to further investigate mitigation strategies to limit the capacity to transmit the disease by individuals that spread the pathogen for extended periods of time. Ultimately, this study suggests that it is crucial for public health researchers to identify appropriate targeted vaccination regimes and to explore the link between PIR and outbreak dynamics to improve the monitoring and mitigating efforts of ongoing and future epidemics.
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- A physiologically-based flow network model for hepatic drug elimination III: 2D/3D DLA lobule models. [Journal Article]
- Theor Biol Med Model 2016; 13:9TB
- CONCLUSIONS: Although, the individual producing ports respond differently, the average lobule production summed over all hepatic veins is more diffuse. Thus the net effect of all these variations makes the overall response smoother. We also show that, in 3D, the effect of zonation on drug production characteristics appears quite small. Our new biophysical structural analysis of a physiologically-based 3D lobule can therefore form the basis for a quantitative assessment of liver function and performance both in health and disease.