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- Comparison of a modified hydrocortisone/urea cream and betamethasone valerate cream in the treatment of dry eczema. [Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial]
- J Int Med Res 1987 Mar-Apr; 15(2):99-105.
A half-sided, single-blind, comparative study of a new modified formulation of 1% hydrocortisone/10% urea and 0.1% betamethasone valerate cream in the treatment of dry eczema showed that the two products were equally effective at the end of 1, 2 and 3 weeks of treatment in terms of efficacy and speed of action. No statistically significant differences could be detected between either preparation in any of the trial's measures (i.e. overall severity score, dryness/scaling, erythema, papules, itching, excoriation or lichenification) at any of the weekly assessments. The incidence of side-effects was the same with both treatments and patients' preference was equally divided between the two creams.
- Contact urticaria and dermatitis to Alphaderm. [Case Reports, Journal Article]
- Contact Dermatitis 1984 Mar; 10(3):178.
- [3-phase therapy. A contribution to the treatment of neurodermatitis atopica (endogenous eczema)]. [English Abstract, Journal Article]
- Z Hautkr 1984 Feb 1; 59(3):157-9.
The treatment of Atopic Dermatitis in 3 periods with a double fluorated corticosteroid-carbamide-ointment, a hydrocortisone, carbamide-ointment and a carbamide-ointment without steroid will be demonstrated. This treatment shows by the base of the tachyphylaxia of the corticosteroid and the biodemand excellent results with a minimum of corticosteroid application.
- Assessment of the skin penetration properties of different carrier vehicles for topically applied cortisol. [Comparative Study, Journal Article]
- Br J Dermatol 1978 Sep; 99(3):307-17.
Four commercially available topical preparations of cortisol, Alphaderm, Calmurid HC, Efcortelan and Topisone, had trace quantities of tritiated cortisol added to them. The resultant radiolabelled creams were applied to the dorsum of the pig and the penetration of the steroid was assessed. Alphaderm was shown to deliver approximately 16.0 times more cortisol to the skin than Topisone, approximately 8.0 times more than Efcortelan and approximately 3.0 times more than Calmurid HC.
- Vasoconstrictor activities and bio-availabilities of seven proprietary corticosteroid creams assessed using a non-occluded multiple dosage regimen; clinical implications. [Comparative Study, Journal Article]
- Br J Dermatol 1977 Nov; 97(5):555-60.
The bio-availabilities and activities of commercial creams (Metosyn, Synalar, Betnovate, Locoid, Alphaderm, Dioderm and Efcortelan 1%) were assessed using a multiple dosage regimen vasoconstrictor assay in ten volunteers. The blanching response first increased but then diminished with continued application over a 5-day period: following a 2-day 'resting period', when no steroid was applied, the application sites recovered considerably but tachyphylaxis again resulted from subsequent repeated applications. Acute tolerance occurred with the hydrocortisone formulations (Alphaderm, Dioderm and Efcortelan 1%) in a manner similar to that observed with the potent preparations. Metosyn was significantly more active (P less than 0.05), and Efcortelan 1% was significantly less active (P less than 0.05), than the other formulations. Apart from the reversal of Dioderm and Alphaderm the rank order of preparations was similar to that previously noted in the 6 h occluded single-application vasoconstrictor test. The results may have significance in dosage from design and application for topical corticosteroid formulations.
- A double-blind comparison of 1% hydrocortisone plus 10% urea ('Alphaderm') and 0.1% betamethasone 17-valerate in the treatment of non-infective inflammatory dermatoses. [Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial]
- Curr Med Res Opin 1977-1978; 5(4):354-8.
A double-blind controlled trial was carried out over a period of 3 weeks to assess the effectiveness of 1% hydrocortisone, in a specialized carbamide drug delivery system, compared with 0.1% betamethasone 17-valerate cream in the treatment of 21 patients with bilateral, symmetrical, non-infective inflammatory dermatoses. The trial preparations were applied topically twice daily, each to one side only during the trial. Although overall patient preference tended to favour betamethasone 17-valerate, the physician's assessment of clinical improvement, based on severity rating scores, indicated that both preparations were equally effective and there were no significant differences between the calculated mean percentage clinical improvements at the end of each week.
- Proprietary hydrocortisone creams. Vasoconstrictor activities and bio-availabilities of six preparations. [Journal Article]
- Br J Dermatol 1976 Oct; 95(4):423-5.
Six proprietary hydrocortisone creams were evaluated for vasoconstrictor activities and bio-availabilities using an occluded blanching test. Statistical analysis showed a significant difference between the formulations. Dioderm, containing 0-1% hydrocortisone, was significantly more active than the 1% hydrocortisone creams--Alphaderm, Calmurid HC, Efcortelan and Vioform-Hydrocortisone. There was no significant difference between Dioderm and Dioderm C. Unlike creams containing more potent corticosteroids the hydrocortisone formulations apparently failed to produce steroid reservoirs in the stratum corneum as assessed by the blanching response.
- Alphaderm- hydrocortisone in a new urea base. [Journal Article]
- Drug Ther Bull 1974 Dec 20; 12(26):103-4.