- Mood spectrum comorbidity in patients with anorexia and bulimia nervosa. [Journal Article]
- EWEat Weight Disord 2016 Oct 20
- CONCLUSIONS: MOODS-SR identifies subthreshold mood signs/symptoms among patients with AN-R, and BN and with no Axis I comorbidity for mood disorders, and provides a better definition of clinical phenotypes.
- Eating disorders Eating disorders S Thompson Chapman & Hall 312pp £14.95 0-412-47420-4. [Journal Article]
- NSNurs Stand 1994 Feb 9; 8(20):44
- Simon Thompson provides comprehensive and practical information on the most common eating disorders. It is divided into four main sections relating to anorexia nervosa, bulimia, obesity and eating di...
Simon Thompson provides comprehensive and practical information on the most common eating disorders. It is divided into four main sections relating to anorexia nervosa, bulimia, obesity and eating disorders that present in people with learning disabilities.
- Plasma kisspeptin and ghrelin levels are independently correlated with physical activity in patients with anorexia nervosa. [Journal Article]
- AAppetite 2016 Sep 28; 108:141-150
- While physical hyperactivity represents a frequent symptom of anorexia nervosa and may have a deleterious impact on the course of the disease, the underlying mechanisms are poorly understood. Since s...
While physical hyperactivity represents a frequent symptom of anorexia nervosa and may have a deleterious impact on the course of the disease, the underlying mechanisms are poorly understood. Since several food intake-regulatory hormones affect physical activity, the aim of the study was to investigate the association of physical activity with novel candidate hormones (kisspeptin, ghrelin, oxyntomodulin, orexin-A, FGF-21, R-spondin-1) possibly involved in patients with anorexia nervosa. Associations with psychometric parameters and body composition were also assessed. We included 38 female anorexia nervosa inpatients (body mass index, BMI, mean ± SD: 14.8 ± 1.7 kg/m(2)). Physical activity was evaluated using portable armband devices, body composition by bioelectrical impedance analysis. Blood withdrawal (hormones measured by ELISA) and psychometric assessment of depressiveness (PHQ-9), anxiety (GAD-7), perceived stress (PSQ-20) and disordered eating (EDI-2) were performed at the same time. Patients displayed a broad spectrum of physical activity (2479-26,047 steps/day) which showed a negative correlation with kisspeptin (r = -0.41, p = 0.01) and a positive association with ghrelin (r = 0.42, p = 0.01). The negative correlation with oxyntomodulin (r = -0.37, p = 0.03) was lost after consideration of potential confounders by regression analysis. No correlations were observed between physical activity and orexin-A, FGF-21 and R-spondin-1 (p > 0.05). Kisspeptin was positively correlated with BMI and body fat mass and negatively associated with the interpersonal distrust subscale of the EDI-2 (p < 0.01). Depressiveness, anxiety, and perceived stress did not correlate with kisspeptin or any other of the investigated hormones (p > 0.05). In conclusion, kisspeptin is inversely and ghrelin positively associated with physical activity as measured by daily step counts in anorexia nervosa patients suggesting an implication of these peptide hormones in the regulation of physical activity in anorexia nervosa.
- Eating disorders: from bench to bedside and back. [Review]
- JNJ Neurochem 2016 Sep 21
- The central-nervous-system and viscera constitute a functional ensemble, the gut-brain axis, that allows bidirectional information flow that contributes to the control of feeding-behaviour based not ...
The central-nervous-system and viscera constitute a functional ensemble, the gut-brain axis, that allows bidirectional information flow that contributes to the control of feeding-behaviour based not only on the homeostatic, but also on the hedonic aspects of food-intake. The prevalence of eating disorders, such as anorexia nervosa, binge eating and obesity, poses an enormous clinical burden, and involves an ever-growing percentage of the population worldwide. Clinical and preclinical research is constantly adding new information to the field and orienting further studies with the aim of providing a foundation for developing more specific and effective treatment approaches to pathological conditions. A recent symposium at the XVI Congress of the Societá Italiana di Neuroscienze (SINS, 2015) "Eating disorders: from bench to bedside and back" brought together basic scientists and clinicians with the objective of presenting novel perspectives in the neurobiology of eating disorders. Clinical studies presented by V. Ricca illustrated some genetic aspects of the psychopathology of anorexia nervosa. Preclinical studies addressed different issues ranging from the description of animal models that mimic human pathologies such as anorexia nervosa, diet induced obesity and binge eating disorders (T. Lutz), to novel interactions between peripheral signals and central circuits that govern food intake, mood and stress (A. Romano and G. Provensi). The gut-brain axis has received increasing attention in the recent years as preclinical studies are demonstrating that the brain and visceral organs such as the liver and guts, but also the microbiota are constantly engaged in processes of reciprocal communication, with unexpected physiological and pathological implications. Eating is controlled by a plethora of factors; genetic predisposition, early life adverse conditions, peripheral gastrointestinal hormones that act directly or indirectly on the central nervous system, all are receiving attention as they presumably contribute to the development of eating disorders. This article is protected by copyright. All rights reserved.
- Gastrointestinal Manifestations of Eating Disorders. [Journal Article]
- JPJ Pediatr Gastroenterol Nutr 2016 Aug 30
- Individuals with eating disorders, including anorexia nervosa and bulimia nervosa, may present with a range of gastrointestinal manifestations. The oral cavity, salivary glands, gastrointestinal trac...
Individuals with eating disorders, including anorexia nervosa and bulimia nervosa, may present with a range of gastrointestinal manifestations. The oral cavity, salivary glands, gastrointestinal tract, pancreas and liver can be impacted by nutritional restrictive and binge/purging behaviors. Complications are often reversible with appropriate nutritional therapy. At times, however, the complications in these disorders may be severe, irreversible and even life threatening. Given the often covert nature of eating disorders, the practitioner must be attentive to subtle clues that may indicate their presence. Extensive diagnostic evaluations of the gastrointestinal manifestations of eating disorders should be employed only when nutritional rehabilitation does not remedy the problems.
- Factors associated with self-identification of an eating disorder history among Latinas meeting criteria for past or current eating disorders. [Journal Article]
- IJInt J Eat Disord 2016 Jul 20
- CONCLUSIONS: Latinas with certain patterns of eating pathology and those with less fear of being stigmatized due to seeking mental health treatment were more likely to endorse an ED history, which has implications for treatment seeking. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016).
- Partially restored resting-state functional connectivity in women recovered from anorexia nervosa. [Journal Article]
- JPJ Psychiatry Neurosci 2016; 41(6):377-385
- CONCLUSIONS: The study design did not allow us to conclude that the difference found in rsFC constitutes a scar effect of the disease.This study suggests that some abnormal rsFC patterns found in patients recovered from anorexia nervosa normalize after long-term weight restoration, while distorted rsFC in the FPN, a network that has been associated with cognitive control, may constitute a trait marker of the disorder.
- Evidence that Illness-Compatible Cues Are Rewarding in Women Recovered from Anorexia Nervosa: A Study of the Effects of Dopamine Depletion on Eye-Blink Startle Responses. [Journal Article]
- PlosPLoS One 2016; 11(10):e0165104
- In anorexia nervosa (AN), motivational salience is attributed to illness-compatible cues (e.g., underweight and active female bodies) and this is hypothesised to involve dopaminergic reward circuitry...
In anorexia nervosa (AN), motivational salience is attributed to illness-compatible cues (e.g., underweight and active female bodies) and this is hypothesised to involve dopaminergic reward circuitry. We investigated the effects of reducing dopamine (DA) transmission on the motivational processing of AN-compatible cues in women recovered from AN (AN REC, n = 17) and healthy controls (HC, n = 15). This involved the acute phenylalanine and tyrosine depletion (APTD) procedure and a startle eye-blink modulation (SEM) task. In a balanced amino acid state, AN REC showed an increased appetitive response (decreased startle potentiation) to illness-compatible cues (underweight and active female body pictures (relative to neutral and non-active cues, respectively)). The HC had an aversive response (increased startle potentiation) to the same illness-compatible stimuli (relative to neutral cues). Importantly, these effects, which may be taken to resemble symptoms observed in the acute stage of illness and healthy behaviour respectively, were not present when DA was depleted. Thus, AN REC implicitly appraised underweight and exercise cues as more rewarding than did HC and the process may, in part, be DA-dependent. It is proposed that the positive motivational salience attributed to cues of emaciation and physical activity is, in part, mediated by dopaminergic reward processes and this contributes to illness pathology. These observations are consistent with the proposal that, in AN, aberrant reward-based learning contributes to the development of habituation of AN-compatible behaviours.
- Long-term follow-up for hospitalized children with anorexia nervosa restricting type. [Journal Article]
- PIPediatr Int 2016 Oct 19
- CONCLUSIONS: This study included hospitalized ANR children aged under 15 years, the youngest cohort ever reported. Long-term prognosis is generally favorable; however, the mortality rate was 5%. Our findings suggest that careful long-term follow-up over 10 years is needed to evaluate outcome of childhood-onset ANR and that family therapy should be focused on high-risk patients with family disorders/problems. This article is protected by copyright. All rights reserved.
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- Eating Disorders and Breast Cancer. [Journal Article]
- CECancer Epidemiol Biomarkers Prev 2016 Oct 18
- CONCLUSIONS: In this large, prospective, observational cohort study, we observed an inverse association between having a history of an eating disorder and invasive breast cancer.Historical eating disorders may be associated with a long-term reduction in breast cancer risk.