- Systematic Guideline Search and Appraisal, as Well as Extraction of Relevant Recommendations, for the DMP "Asthma" [BOOK]
- BOOKInstitute for Quality and Efficiency in Health Care (IQWiG): Cologne, Germany
- The aim of this study was to specify a potential need for updating and supplementation of the existing DMP “Asthma” by means of a systematic search for new evidence-based guidelines relevant to the s...
The aim of this study was to specify a potential need for updating and supplementation of the existing DMP “Asthma” by means of a systematic search for new evidence-based guidelines relevant to the subject and by synthesis of the guideline recommendations. The study was organized as follows:literature search for and selection of current guidelines on the subject of asthma; appraisal of the methodological quality of the selected guidelines; extraction and synthesis of guideline recommendations relevant to the existing DMP “Asthma” identification of recommendations that might justify the potential need to revise and supplement the DMP “Asthma” It was not the aim of the study to provide recommendations in terms of an IQWiG benefit assessment.
- GATA-3-specific DNAzyme - A novel approach for stratified asthma therapy. [Review]
- EJEur J Immunol 2016 Dec 2
- It is now well established that type-2 immune mechanisms drive the inflammation in about 50% of asthma patients. The major cellular and molecular players regulating this important network have been i...
It is now well established that type-2 immune mechanisms drive the inflammation in about 50% of asthma patients. The major cellular and molecular players regulating this important network have been identified. In terms of therapeutic intervention, cytokine and cytokine-receptor pathways have been given major attention, since these molecules are relatively easily accessible for a blockade through monoclonal antibodies, and a number of positive clinical results support this concept. However, targeting events controlling the type-2 immunity network upstream of selective cytokine pathways would be equally attractive. Type-2 immunity is regulated through a delicate interplay of several transcription factors (including GATA-3, STAT-6, NFAT, IRF4, c-maf), with GATA-3 as master regulator in this regard. Since transcription factors are intracellularly located they cannot be directly targeted by monoclonal antibodies. For intracellular targets, antisense technologies such as antisense DNA and siRNA have been shown to be a promising approach, and have recently made major advances towards clinical application. Here we summarize the development of a GATA-3-specific DNAzyme - a molecule class that combines the superior specificity of antisense molecules with an inherent RNA-cleaving enzymatic activity - for the treatment of type-2-driven asthma from preclinical development towards a proof-of-concept clinical study. This article is protected by copyright. All rights reserved.
- Omalizumab in Severe Refractory Vernal Keratoconjunctivitis in Children: Case Series and Review of the Literature. [Journal Article]
- OTOphthalmol Ther 2016 Dec 1
- CONCLUSIONS: Omalizumab is an interesting treatment in severe refractory forms of VKC, but its efficacy is incomplete in these very severe cases.
- Clinical pharmacokinetics of magnesium sulfate in the treatment of children with severe acute asthma. [Journal Article]
- EJEur J Clin Pharmacol 2016 Dec 2
- CONCLUSIONS: These results provide new insight into the disposition of IV MgSO4 in children and provide dosing guidelines for future prospective studies of IV MgSO4 in children with acute asthma.
- Biological treatment is approved for severe eosinophilic asthma. [Journal Article]
- BMJBMJ 2016 Nov 30; 355:i6472
- DTB Select: 12 | December 2016. [Journal Article]
- DTDrug Ther Bull 2016 Dec 1
- Azithromycin of no benefit for asthma attacks ● Risk of heart failure with NSAIDs ● Bisphosphonates and steroid-induced osteoporosis ● Triple therapy for moderate-to-severe COPD: marginal benefits ● ...
Azithromycin of no benefit for asthma attacks ● Risk of heart failure with NSAIDs ● Bisphosphonates and steroid-induced osteoporosis ● Triple therapy for moderate-to-severe COPD: marginal benefits ● Much data on adverse events remains unpublished ● Rising placebo response rates in antidepressant trials a 'myth' ● Prenatal fetal RhD testing recommended.
- The Effectiveness of Web-Based Asthma Self-Management System, My Asthma Portal (MAP): A Pilot Randomized Controlled Trial. [Journal Article]
- JMJ Med Internet Res 2016 Dec 01; 18(12):e313
- CONCLUSIONS: This study supported the use of MAP to enhance asthma quality of life but not asthma control as measured by an administrative database. Implementation of MAP beyond 6 months with tailored protocols for monitoring symptoms and health behaviors as individuals' knowledge and self-management skills improve may result in long-term gains in asthma control.
- Inhibitory effects of L-theanine on airway inflammation in ovalbumin-induced allergic asthma. [Journal Article]
- FCFood Chem Toxicol 2016 Nov 28
- L-theanine, a water-soluble amino acid isolated from green tea (Camellia sinensis), has anti-inflammatory activity, antioxidative properties, and hepatoprotective effects. However, the anti-allergic ...
L-theanine, a water-soluble amino acid isolated from green tea (Camellia sinensis), has anti-inflammatory activity, antioxidative properties, and hepatoprotective effects. However, the anti-allergic effect of L-theanine and its underlying molecular mechanisms have not been elucidated. In this study, we investigated the protective effects of L-theanine on asthmatic responses, particularly airway inflammation and oxidative stress modulation in an ovalbumin (OVA)-induced murine model of asthma. Treatment with L-theanine dramatically attenuated the extensive trafficking of inflammatory cells into bronchoalveolar lavage fluid (BALF). Histological studies revealed that L-theanine significantly inhibited OVA-induced mucus production and inflammatory cell infiltration in the respiratory tract and blood vessels. L-theanine administration also significantly decreased the production of IgE, monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-4, IL-5, IL-13, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (INF-γ) in BALF. The lung weight decreased with L-theanine administration. L-theanine also markedly attenuated the OVA-induced generation of reactive oxygen species and the activation of nuclear factor kappa B (NF-κB) and matrix metalloprotease-9 in BALF. Moreover, L-theanine reduced the TNF-α-induced NF-κB activation in A549 cells. Together, these results suggest that L-theanine alleviates airway inflammation in asthma, which likely occurs via the oxidative stress-responsive NF-κB pathway, highlighting its potential as a useful therapeutic agent for asthma management.
- Effectiveness of immunotherapy in children depends on place of living - A pilot study. [Journal Article]
- AIAllergol Immunopathol (Madr) 2016 Nov 28
- CONCLUSIONS: The current analysis of the better AIT effectiveness in the farm population has shown the protective influence of environmental exposures on asthma and allergic rhinitis in our children.
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- Asthma Among Employed Adults, by Industry and Occupation - 21 States, 2013. [Journal Article]
- MMMMWR Morb Mortal Wkly Rep 2016 Dec 02; 65(47):1325-1331
- Workers in various industries and occupations are at risk for work-related asthma* (1). Data from the 2006-2007 adult Behavioral Risk Factor Surveillance System (BRFSS) Asthma Call-back Survey (ACBS)...
Workers in various industries and occupations are at risk for work-related asthma* (1). Data from the 2006-2007 adult Behavioral Risk Factor Surveillance System (BRFSS) Asthma Call-back Survey (ACBS), an in-depth asthma survey conducted with respondents who report an asthma diagnosis, from 33 states indicated that up to 48% of adult current asthma might be related to work and could therefore potentially be prevented (2). Identification of the industries and occupations with increased prevalence of asthma might inform work-related asthma intervention and prevention efforts. To assess the industry-specific and occupation-specific proportions of adults with current asthma by state, CDC analyzed data from the 2013 BRFSS industry and occupation module, collected from 21 states for participants aged ≥18 years who, at the time of the survey interview, were employed or had been out of work for <12 months. Among these respondents, 7.7% had current asthma; based on the Asthma Call-back Survey results, this finding means as many as 2.7 million U.S. workers might have asthma caused by or exacerbated by workplace conditions. State-specific variations in the prevalence of current asthma by industry and occupation were observed. By state, current asthma prevalence was highest among workers in the information industry (18.0%) in Massachusetts and in health care support occupations (21.5%) in Michigan. Analysis of BRFSS industry and occupation and optional asthma modules can be used to identify industries and occupations to assess for asthma among workers, identify workplace exposures, and guide the design and evaluation of effective work-related asthma prevention and education programs (1).