Deep burn injuries in mammals typically heal with fibrosis and scar formation. Although the Japanese fire-bellied newt (Cynops pyrrhogaster) exhibits scarless skin regeneration after injury, whether this capacity is maintained after third-degree burn remains unclear. A third-degree burn model was established in adult newts, and the regenerative process was analysed over 1 year using macroscopic, histological, ultrastructural and molecular approaches. Blood cell dynamics and proliferative cells were evaluated by Wright-Giemsa staining and PCNA immunohistochemistry. Burn wounds were completely re-epithelialised by post-burn day (PBD) 8 despite persistence of damaged tissue. The wound subsequently underwent progressive tissue remodelling and closely resembled normal skin macroscopically by PBD 365 without evidence of contracture. Histological and ultrastructural analyses demonstrated restoration of organised dermal collagen architecture and muscle sarcomere structures without fibrotic scar formation. Erythrocytes transiently accumulated within damaged tissues and peaked on PBD 12, whereas neutrophils peaked earlier and declined after re-epithelialisation. PCNA-positive proliferative cells in the dermis and subcutaneous tissue peaked on PBD 30. Semi-quantitative RT-PCR suggested temporal changes in inflammatory marker expression during the regenerative process. Adult newts achieve scarless regeneration following third-degree burns. These findings establish a useful experimental model and provide a comprehensive characterisation of scarless regeneration following third-degree burns, providing a foundation for future mechanistic studies.

Distracted driving is a recognized pedestrian safety risk, yet behavioral heterogeneity within distraction periods remains poorly characterized. We analyze 39,271 one-second observations from 720 naturalistic crosswalk traversals (162 drivers, SHRP2 NDS, 2008-2013) using a Hidden Markov Model (HMM) and Gaussian Mixture Model (GMM) pipeline. Five kinematic states form a near-sequential deceleration cascade, with nondriving-related task (NDRT) engagement concentrated in low-demand states. Monte Carlo cross-validation identified two driver profiles distinguished not by distraction frequency, which differed only negligibly once signal-phase exposure was accounted for, but by regulatory responsiveness: the degree to which approach speed responds to traffic control. The Regulated Tasker (27.7 km/h aggregate approach speed) adjusted speed with the regulatory environment; the Unregulated Tasker (43.9 km/h) responded about a third less strongly. A mixed-effects model on all 162 drivers confirmed that drivers differ significantly in regulatory responsiveness (p=0.024) and that task-active periods were slower, not faster, within driver. An event-triggered analysis of 395 NDRT onsets showed that speed change temporally preceded task engagement, consistent with demand-drop task timing; task-active seconds disrupted the orderly deceleration cascade and shifted initial deceleration onset 102.8 m closer to the crosswalk. The infrastructure-resistant subtype (Unregulated Tasker) is the safety-critical finding: its risk appears less amenable to signal-based control, suggesting physical speed management as a candidate countermeasure to be tested.

Quantum geometry, describing the inherent geometric structure of electron wavefunctions in momentum space, transcends the traditional charge degree of freedom and provides a novel physical basis for information encoding and processing. The key to such new computing paradigms is the nonvolatile electrical programming of quantum geometric states at room temperature, which, however, has not been established. Here, we demonstrate ferroelectrically switchable quantum geometry in few-layer WTe2, which uniquely enables complementary convolutional processing. By employing the intrinsic coupling between ferroelectric polarization and quantum geometry in few-layer WTe2, we show that the second- and third-order nonlinear anomalous Hall effects (NLAHE) can be deterministically and electrically switched in a nonvolatile and correlated manner. The switching is robust at room temperature for ~10[4] cycles and retention of ~10[5 ]s. Furthermore, leveraging the opposite switching behaviors of second- and third-order NLAHE at room temperature, we demonstrate complementary in-memory computing and implement a hardware-level complementary convolution kernel. This kernel overcomes the inherent directional specificity of conventional convolutional networks and achieves a texture recognition accuracy of 98%, thereby illustrating a viable pathway towards physics-native computing through exploiting exotic physics in quantum materials.

The hepatitis C virus (HCV) is a significant healthcare burden across the globe and is a major cause of liver malignancies. However, patients with serious mental illness (SMI) living with HCV are disproportionately affected and underserved within the current care framework. A previous meta-analysis on this topic yielded a prevalence of 8%, which is considerably higher than that observed in the broader population. Since the original review was published in early 2022, an update is required to incorporate data published during and after the COVID-19 pandemic and to evaluate its effect on overall prevalence and care.

Interacting with nature has significant benefits for our physical and psychosocial health. However, a lack of contact with nature has been linked to various pathologies such as obesity, asthma, neurodevelopmental disorders, and learning disabilities. Furthermore, excessive screen use is also associated with health problems in children and adolescents, such as obesity, mental health problems (anxiety, depression), and sleep disorders. Lack of contact with nature from an early age, combined with excessive screen use, contributes to an unhealthy lifestyle and has been associated with the development of these pathologies. This study aims to analyze the relationship between the degree of connection with nature, and the incidence of childhood and adolescent obesity and other common pathologies in Primary Care pediatric clinics: asthma, neurodevelopmental disorders, emotional and psychiatric disorders, as well as sleep disorders and worsening perceived quality of life. A descriptive cross-sectional study will be conducted through the PAPenRed research group of the Spanish Association of Primary Care Pediatrics (AEAPap) over a 12-month period (July 2025 to June 2026). During health visits for children aged seven to fourteen, three surveys will be administered simultaneously: one for the child, another for the parents, and a third for the pediatrician.

ESBL-producing bacteria are a problem in patients with cancer. The emergence of XDR phenotypes with ESBLs increases mortality. We aimed to evaluate ESBL-producing bacteria, the prevalence of MDR and XDR phenotypes, ESBL genes, and mortality predictors in patients with cancer in the ICU. Different clinical cultures were collected from patients in oncology ICUs. We used the VITEK2 system to identify isolates and assess antibiotic sensitivity, and the combination disk method to detect ESBL phenotypes. β-lactamase, ESBL, and carbapenem genes were detected using PCR. 136 isolates were ESBL-producing. Respiratory cultures were the main source, followed by blood cultures. K. pneumoniae was the most common, followed by E. coli. Isolates showed high resistance to third- and fourth-generation cephalosporins and carbapenem antibiotics. 84.6% and 13.2% of isolates were XDR and MDR, respectively. The most harbored genes were SHV and TEM (94.1%), CTXM-15 (59.6%), SHV-12 (67.6%), and NDM (78.7%). 38.2% of isolates harbored seven β-lactamase, ESBL, and carbapenem genes. K. pneumoniae significantly harbored more ESBL and carbapenem genes than E. coli. Patient age, relapses, and hospital stay are predictors of mortality in patients. An improved surveillance program and antibiotic stewardship are urgently needed.

M. R. Abid, J. C. Tsai, K. C. Spokes, S. S. Deshpande, K. Irani, W. C. Aird, "Vascular Endothelial Growth Factor Induces Manganese-Superoxide Dismutase Expression in Endothelial Cells by a Racl-regulated NADPH Oxidase-Dependent Mechanism," The FASEB Journal 15, no. 13 (2001): 2548-2550, https://doi.org/10.1096/fj.01-0338fje. The above article, published online on 17 September 2001 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Loren E. Wold; the Federation of American Societies for Experimental Biology; and Wiley Periodicals, LLC. The retraction has been agreed due to concerns raised by third parties. Specifically, image duplications within Figure 1B, between Figure 1A and Figure 2A, and within Figure 5C have been detected, with the same panels being presented in a different scientific context. The corresponding author stated that the raw data were no longer available due to the time elapsed since publication. Nevertheless, the corresponding author and the first author cooperated with the investigation and provided their own assessment based on the available resources. They confirmed a high degree of similarity affecting the Western blot panels in question but maintained that, because the original source materials could not be located, unresolved uncertainty remained as to whether the panels were duplicated. They also disputed the characterization of the panels shown in Figure 5C as duplicated. However, the editors considered the response and supporting materials insufficient to resolve the concerns, as the similarities were found too extensive to be attributable to coincidence. Accordingly, the article has been retracted, as the editors have lost confidence in the results and conclusions presented. The first author and the corresponding author were informed of the retraction decision and disagreed with it. The remaining co-authors could not be reached.

The unitary coupled cluster (UCC) algorithm is one of the most promising implementations of the variational quantum eigensolver for quantum computers. However, for large systems, the number of UCC factors leads to deep quantum circuits, which are prohibitive for execution on quantum hardware. To address this, circuit depth can be reduced at the cost of more measurements with a Taylor series expansion of UCC factors with small angles, while treating the large-angle factors exactly. We implement this approach to quadratic order (qUCC) for systems with strong correlations and systems where conventional methods, such as coupled cluster (CC) with low excitation levels, fail, but UCC and qUCC perform well. We study hydrogen chains and the BeH2 molecule that allow us to change the degree of strong correlation due to geometrical distortions. We show, via a dramatic increase in the number of factors able to be handled exactly, a systematic convergence of these results as more exact UCC factors are included in the calculations-the hardest to converge regime is in the crossover from weak to strong coupling. In all cases, the total number of UCC factors needed to be treated exactly is much less than the total number of UCC factors available (typically about one-third to one-half of the total number of factors).

Northeast Ohio Medical University (NEOMED)'s annual poetry competition was named for and envisioned in the spirit of the iconic American poet and pioneering patient-centered physician William Carlos Williams. It honors his legacy by celebrating contemporary clinician writers-both medical students and established practitioners-whose work illustrates the art of medicine and the dynamic interplay of health care and the humanities. An influential poet in the imagist movement in modernist art and literature, Williams' poetry is appreciated for its stark minimalism and vivid attention to the details of early twentieth-century life, particularly in the working-class neighborhoods outside of New York City where he practiced medicine. While Williams at times struggled to balance his desire to write with the demands of his medical practice, his medical career afforded him the financial freedom to write, as well as the inspiration for poems jotted down on prescription blanks in the breaks between patient visits. Each of the past 44 years, NEOMED has recognized exceptional medical student poetry by awarding first-, second-, and third-place prizes, as well as honorable mentions, to students enrolled in a medical degree program in the US, Puerto Rico, or Canada. Having begun under the leadership of Drs. Delese Wear and Martin Kohn in 1982, NEOMED's William Carlos Williams poetry competition is the oldest running poetry competition for medical students in the United States. The competition introduced a new category for physician poets in 2025, welcoming submissions from any rank of physician (MD or DO) at any career stage, from residency to retirement, in North America.

To address the current challenges of difficult removal and potential residuals of soft tissue foreign bodies, this paper utilizes the principle of different light reflection degrees between foreign bodies and tissues to construct a foreign body localization device based on modified PMMA optical fibers. An optical fiber light transmission method is designed for the localization of soft tissue foreign bodies. To verify the practicality and reliability of the device, tests and comparisons are conducted on biological tissue models. The results show that the device can locate foreign bodies more efficiently and at lower cost, facilitating the complete removal of soft tissue foreign bodies.