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- Lipoxin A4 and Neutrophil/Lymphocyte Ratio: A Possible Indicator in Achieved Systemic Risk Factors for Periodontitis. [Journal Article]
- Med Sci Monit 2015.:2485-93.
- NLRP3 Inflammasome Polymorphism and Macrovascular Complications in Type 2 Diabetes Patients. [Journal Article]
- J Diabetes Res 2015.:616747.
Background.It is generally accepted that poor glycemic control, arterial hypertension and/or hyperlipidemia, and the associated oxidative stress may contribute to the development of macro- and microvascular complications in type 2 diabetes (T2D). Such metabolic damage signals may activate inflammasome and trigger chronic inflammation. We investigated common polymorphisms in inflammasome coding genes and the risk for macro- and microvascular complications in T2D. Methods. In total 181 clinically well-characterised T2D patients were genotyped for NLRP3 rs35829419 and CARD8 rs2043211. Risk for diabetic complications was assessed using logistic regression.
Results.Patients with median duration of T2D 11 (6-17) years had relatively well controlled blood glucose and lipid levels and blood pressure on the prescribed treatment regimen. Duration of T2D and plasma cholesterol levels were the most important clinical risk factors for macrovascular complications (P = 0.007 and P = 0.031). NLRP3 rs35829419 was associated with increased risk for macrovascular complications (P = 0.004), with myocardial infarction in particular (P = 0.052). No association was observed between CARD8 polymorphism and any of T2D complications.
Conclusions.Our preliminary data suggest the role of NLRP3 polymorphism in diabetic macrovascular complications, especially in myocardial infarction.
- Dyslipidaemia and the military patient. [Journal Article, Review]
- J R Army Med Corps 2015 Sep; 161(3):206-10.
- Congenital generalized lipodystrophies-new insights into metabolic dysfunction. [Journal Article, Review]
- Nat Rev Endocrinol 2015 Sep; 11(9):522-34.
- Cost-Effectiveness of a Diabetes Pay-For-Performance Program in Diabetes Patients with Multiple Chronic Conditions. [Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't]
- PLoS One 2015; 10(7):e0133163.
- Cardiovascular risk factors and diseases in women undergoing hysterectomy with ovarian conservation. [JOURNAL ARTICLE]
- Menopause 2015 Jul 13.
- Increased Cardiovascular and Metabolic Morbidity in Patients With 21-Hydroxylase Deficiency: A Swedish Population-Based National Cohort Study. [Journal Article]
- J Clin Endocrinol Metab 2015 Sep; 100(9):3520-8.
- C-Peptide Is Independently Associated with an Increased Risk of Coronary Artery Disease in T2DM Subjects: A Cross-Sectional Study. [Journal Article, Research Support, Non-U.S. Gov't]
- PLoS One 2015; 10(6):e0127112.
- The Effect of Diabetes, Hyperlipidemia, and Statins on the Development of Rotator Cuff Disease: A Nationwide, 11-Year, Longitudinal, Population-Based Follow-up Study. [Journal Article]
- Am J Sports Med 2015 Sep; 43(9):2126-32.
- Increased concentration of clusterin/apolipoprotein J (apoJ) in hyperlipemic serum is paradoxically associated with decreased apoJ content in lipoproteins. [Journal Article, Research Support, Non-U.S. Gov't]
- Atherosclerosis 2015 Aug; 241(2):463-70.