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- Sirolimus-based immunosuppression as GVHD prophylaxis after bone marrow transplantation for severe aplastic anaemia: a case report and review of the literature. [Journal Article]
- Case Rep Hematol 2015.:321602.
- A cluster of central line-associated bloodstream infections due to rapidly growing nontuberculous mycobacteria in patients with hematologic disorders at a Japanese tertiary care center: an outbreak investigation and review of the literature. [Journal Article]
- Infect Control Hosp Epidemiol 2015 Jan; 36(1):76-80.
BACKGROUNDRapidly growing nontuberculous mycobacteria (RGM) are considered rare pathogens, causing central line-associated bloodstream infection. We identified an outbreak of central line-associated bloodstream infection due to RGM at a hematology-oncology ward during a 5-month period. DESIGN Outbreak investigation and literature review. SETTING A Japanese tertiary care center. PATIENTS Adults who were hospitalized at the hematology-oncology ward from October 15, 2011, through February 17, 2012.
RESULTSA total of 5 patients with a bloodstream infection due to RGM (4 cases of Mycobacterium mucogenicum and 1 case of Mycobacterium canariasense infection) were identified; of these, 3 patients had acute myeloid leukemia, 1 had acute lymphocytic leukemia, and 1 had aplastic anemia. Four of the 5 patients received cord blood transplantation prior to developing the bloodstream infection. All central venous catheters in patients with a bloodstream infection were removed. These patients promptly defervesced after catheter removal and their care was successfully managed without antimicrobial therapy. Surveillance cultures from the environment and water detected M. mucogenicum and M. canariasense in the water supply of the hematology-oncology ward. The isolates from the bloodstream infection and water sources were identical on the basis of 16S-rRNA gene sequencing.
CONCLUSIONSThe source of RGM in the outbreak of bloodstream infections likely was the ward tap water supply. Awareness of catheter-related bloodstream infections due to nontuberculous mycobacteria should be emphasized, especially where immunocompromised patients are at risk. Also, using antimicrobials after catheter removal to treat central line-associated bloodstream infection due to RGM may not be necessary. Infect Control Hosp Epidemiol 2015;36(1): 76-80.
- [In vitro functions of natural killer cells in peripheral blood of patients with severe aplastic anemia]. [English Abstract, Journal Article]
- Zhonghua Yi Xue Za Zhi 2014 Dec; 94(48):3845-7.
- Aplastic Anemia: Alternative Immunosuppressive Treatments and Eltrombopag. A report from the 2014 EBMT Educational Meeting from the Severe Aplastic Anaemia and Infectious Diseases Working Parties. [JOURNAL ARTICLE]
- Curr Drug Targets 2015 Jan 25.
- Current outcome of HLA identical sibling vs. unrelated donor transplants in severe aplastic anemia: an EBMT analysis. [JOURNAL ARTICLE]
- Haematologica 2015 Jan 23.
- [Defectiveness of bone marrow mesenchymal stem cells in acquired aplastic anemia]. [English Abstract, Journal Article]
- Zhongguo Dang Dai Er Ke Za Zhi 2015 Jan; 17(1):100-6.
- [Clinical features of childhood refractory cytopenia]. [English Abstract, Journal Article]
- Zhongguo Dang Dai Er Ke Za Zhi 2015 Jan; 17(1):15-21.
- Efficacy of porcine antihuman lymphocyte immunoglobulin compared to rabbit antithymocyte immunoglobulin as a first-line treatment against acquired severe aplastic anemia. [JOURNAL ARTICLE]
- Ann Hematol 2015 Jan 22.
- Mutations of ASXL1 and TET2 in aplastic anemia. [JOURNAL ARTICLE]
- Haematologica 2015 Jan 16.