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6,449 results
  • Pituitary tumors in MEN1: do not be misled by borderline elevated prolactin levels. [Journal Article]
  • PPituitary 2016 Sep 6
  • Livshits A, Kravarusic J, … Molitch ME
  • CONCLUSIONS: Small, intrasellar microadenomas may be associated with elevated PRL levels due to possible direct hormone production [prolactinoma] or possibly to interference with portal vessel blood flow. In monitoring hyperprolactinemic MEN1 patients for the development of pituitary adenomas, measurement of PRL levels is insufficient and periodic MRI scans are necessary at a more frequent interval than every 3-5 years. This may also pertain to patients with "idiopathic" hyperprolactinemia.
  • Gigantism: X-linked acrogigantism and GPR101 mutations. [Review]
  • GHGrowth Horm IGF Res 2016 Sep 29
  • Iacovazzo D, Korbonits M
  • X-linked acrogigantism (XLAG) is a recently identified condition of early-onset GH excess resulting from the germline or somatic duplication of the GPR101 gene on chromosome Xq26.3. Thirty patients h...
  • Erdheim-Chester disease (ECD): Case report, clinical and basic investigations, and review of literature. [Journal Article]
  • MMedicine (Baltimore) 2016; 95(42):e5167
  • Adawi M, Bisharat B, Bowirrat A
  • CONCLUSIONS: Clinical presentation, imaging studies, distinctive pathological findings, followed by bone biopsy showed a non-Langerhans cell histiocytosis, supported by immunohistochemistry exams are essential for the diagnosis. Radiation therapy and Bisphosphonates in addition to cladribine, anakinra, infliximab and vemurafenib (BRAF Inhibitors) are currently advocated as promising second line treatment for patients whose response to interferon-α is unsatisfactory.
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