(Jaundice (icterus)) articles in PubMed
- Vanishing Bile Ducts, Cholesatatic Jaundice and Portal Hypertension Secondary to Hepatic ALECT-2 Amyloid Deposition. [Journal Article]
- J Clin Gastroenterol 2016 Sep 22JC
- Hepatocellular Carcinoma With Budd-Chiari Syndrome and Obstructive Jaundice: A Therapeutic Challenge. [Journal Article]
- Am J Ther 2016 Sep 19AJ
- Utility of the 2006 Sendai and 2012 Fukuoka guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas: A single-center experience with 138 surgically treated patients. [Journal Article]
- Medicine (Baltimore) 2016; 95(38):e4922M
- This study aimed to evaluate the utility of the 2006 Sendai and 2012 Fukuoka guidelines for differentiating malignant intraductal papillary mucinous neoplasm (IPMN) of the pancreas from benign IPMN.B...
This study aimed to evaluate the utility of the 2006 Sendai and 2012 Fukuoka guidelines for differentiating malignant intraductal papillary mucinous neoplasm (IPMN) of the pancreas from benign IPMN.Between January 2000 and March 2015, a total of 138 patients underwent surgery and had a pathologically confirmed pancreatic IPMN. Clinicopathological parameters were reviewed, and all patients were classified according to both the 2006 Sendai and 2012 Fukuoka guidelines. Univariate and multivariate analyses were used for identifying significant factors associated with malignancy in IPMN.There were 9 high-grade dysplasia (HGD) and 37 invasive cancers (ICs) in the 138 patients. The positive predictive value (PPV) and negative predictive value (NPV) of the Sendai and Fukuoka guidelines for HGD/IC was 35.1%, 43.3%, 100%, and 85.4%, respectively. Of the 36 patients with worrisome features using the Fukuoka guideline, 7 patients had HGD/IC in their IPMNs. According to the multivariate analysis, jaundice, tumors of ≥3 cm, presence of mural nodule on imaging, and aged <65 years were associated with HGD/IC in patients with IPMN.The Sendai guideline had a better NPV, but the Fukuoka guideline had a better PPV. We suggest that patients with worrisome features based on the Fukuoka guideline be aggressively managed.
- Severe liver involvement in two patients with long-term history of fever: remember familial Mediterranean fever. [Journal Article]
- BMJ Case Rep 2016; 2016BC
- Familial Mediterranean fever (FMF) is characterised by recurrent, self-limited fever attacks and serositis. Severe liver involvement has rarely been reported. We present two FMF cases of a 55-year-ol...
Familial Mediterranean fever (FMF) is characterised by recurrent, self-limited fever attacks and serositis. Severe liver involvement has rarely been reported. We present two FMF cases of a 55-year-old man and a 20-year-old woman in whom the prevailing manifestations were recurrent unexplained episodes of anicteric hepatitis (man) and recurrent severe jaundice (woman). A long-term history of recurrent self-limited episodes of fever was also claimed in both. After exclusion of infectious, malignant, autoimmune, and liver and biliary diseases, a diagnosis of FMF as confirmed by molecular analysis was established. The patients started colchicine 1 mg/day with immediate resolution of symptoms. During follow-up, no new episodes of fever and exacerbation of liver biochemical parameters have been recorded for 5 and 1 years. Physicians must keep FMF in mind in patients with recurrent episodes of unexplained severe liver impairment and fever and especially in regions like Mediterranean basin where hereditary periodic fever syndromes are common.
- FOXP3 PROMOTOR METHYLATION IMPAIRS SUPPRESSIVE FUNCTION of REGULATORY T CELLS in BILIARY ATRESIA. [Journal Article]
- Am J Physiol Gastrointest Liver Physiol 2016 Sep 22; :ajpgi.00032.2016AJ
- Biliary atresia (BA) is a pediatric inflammatory disease of the biliary system which leads to cirrhosis and the need for liver transplantation. Various cells types have been reported to participate i...
Biliary atresia (BA) is a pediatric inflammatory disease of the biliary system which leads to cirrhosis and the need for liver transplantation. Various cells types have been reported to participate in the pro-inflammatory response, including Th1, Th2, Th17, CD8(+) T cells, or NK cells. The suppressive Treg cells, on the contrary, were not functioning properly. The underlying mechanism is largely unknown. Focusing on why the suppressive function of Treg was impaired, we found out methylation status of CpG islands within the Foxp3 promotor of Tregs in BA patients and murine models were both increased. Moreover, when injecting Aza as DNA-methylation inhibitor to RRV infected mice, jaundice rate were decreased and survival of the mice were prolong. Strikingly, Tregs isolated from Aza treated infected mice had better suppressive function than Tregs from the infected mice without Aza treatment. Besides, IL-17+Treg cells and Th17 cells were both elevated in mice when Foxp3 expression was epigenetically down regulated. Thus we concluded that aberrant increased demethylation status of "Foxp3 promoter" in Treg cells leads to impaired Treg suppressive function and participated in inflammatory injury to extrahepatic and intrathepatic bile duct in BA.
- [Maternal death from severe malaria due to Plasmodium vivax]. [Journal Article]
- Rev Peru Med Exp Salud Publica 2016; 33(2):368-72RP
- Here we describe the case of a 19-year-old woman, in her 29th week of gestation, who was from Llumpe (Ancash, Peru) and had a history of traveling to Chanchamayo (Junín, Peru) and Rinconada (Ancash, ...
Here we describe the case of a 19-year-old woman, in her 29th week of gestation, who was from Llumpe (Ancash, Peru) and had a history of traveling to Chanchamayo (Junín, Peru) and Rinconada (Ancash, Peru). The patient presented at Chacas Hospital (Chacas, Ancash, Peru) with general malaise, dehydration, respiratory distress, jaundice, the sensation of thermal rise, and abdominal pain. Analysis of blood smears revealed 60% hemoparasites. She was transferred to Ramos Guardia Hospital (Huaraz, Peru) where she presented increasing respiratory distress, choluria, hematuria, and decreased urine output, moreover she was positive for Plasmodium. From there she was transferred to Cayetano Heredia Hospital (Lima, Peru), where she was admitted to the intensive care unit (ICU) with multiple organ failure, stillbirth, and leading to death. She underwent mechanical ventilation, was administered clindamycin, and was prescribed quinine, which she did not received due a lack by availability. The evolution of the illness was torpid, and she ultimately developed multiple organ failure and died. Plasmodium vivax infection was confirmed. Accordingly, we emphasize the importance of improving our diagnostic capabilities and management techniques to enable clinicians to provide adequate and timely treatment.
- Domestic Diagnosis of Newborn Bilirubin Levels? [Journal Article]
- Acta Paediatr 2016 Sep 22AP
- Attempts to refine our ability to provide a visual estimate of an infant's total serum bilirubin (TSB) level go back to the Ingram Icterometer, described in 1960 by Gosset, (1) (and still available f...
Attempts to refine our ability to provide a visual estimate of an infant's total serum bilirubin (TSB) level go back to the Ingram Icterometer, described in 1960 by Gosset, (1) (and still available for the princely sum of $20 [Birthwithlove. com]) but the idea of a device that allows the parent to report the TSB to the healthcare professional is new but not entirely unique. Taylor et al have recently described the use of a smartphone to perform the same function suggested by Guo-Chang et al (2) although the former is certainly far more expensive and would be limited to families fortunate enough to have such a phone. The data presented by Guo-Chang et al are quite startling for their simplicity and accuracy. This article is protected by copyright. All rights reserved.
- Budd-Chiari Syndrome Causing Acute Liver Failure: A Multicenter Case Series. [Journal Article]
- Liver Transpl 2016 Sep 22LT
- CONCLUSIONS: Budd-Chiari syndrome is a rare cause of ALF and mandates prompt diagnosis and management for successful outcomes. Once the diagnosis is confirmed, prompt anticoagulation is recommended in conjunction with evaluation for malignancy or thrombophilic disorder. Mortality may have improved in recent years with use of TIPS and/or OLT compared to prior published reports. This article is protected by copyright. All rights reserved.
- Hepatosplenic T Cell Lymphoma in an Immunocompetent Female Diagnosed using Flow Cytometry: A Rare Clinical Entity. [Journal Article]
- J Clin Diagn Res 2016; 10(8):ED15-6JC
- Hepatosplenic T-cell lymphoma is a rare haematopoietic malignancy that comprises less than 1% of Non-Hodgkin lymphomas. We are reporting a case of a 26-year-old female, who presented with pallor, wei...
Hepatosplenic T-cell lymphoma is a rare haematopoietic malignancy that comprises less than 1% of Non-Hodgkin lymphomas. We are reporting a case of a 26-year-old female, who presented with pallor, weight loss, jaundice, pancytopenia and hepatosplenomegaly. The bone marrow examination showed infiltration by lymphoid cells. These cells on flow cytometric evaluation showed the phenotype of hepatosplenic T cell lymphoma. The cells were positive for CD3, CD8, CD56 and TCR γδ and negative for CD5, CD4, CD8, CD16, CD57, TCRαβ along with B cell markers. This case is reported for being a rare clinical entity and its presence in an immunocompetent female making it rarer.
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- Biliary cysts in adults. 26 years experience at a single center. [Journal Article]
- Ann Med Surg (Lond) 2016; 11:29-31AM
- CONCLUSIONS: Vague clinical presentation results on a delay of the diagnosis and treatment. Surgical resection is recommended for patients since they have an increased risk for malignant transformation. Postoperative complications in our patients were stenosis of bilioenteric anastomosis in 3 (12%) patients.Biliary cysts require an accurate diagnosis and surgical treatment in order to decrease the risk of malignant transformation and progression of the disease. Precise surgical treatment is needed to achieve complete resection and a long term postoperative follow up is mandatory.