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- Omitting edema measurement: how much acute malnutrition are we missing? [JOURNAL ARTICLE]
- Am J Clin Nutr 2015 Sep 16.
- A kwashiorkor case due to the use of an exclusive rice milk diet to treat atopic dermatitis. [Journal Article]
- Nutr J 2015.:83.
- Antioxidant and Anti-Inflammatory Activities of Kenyan Leafy Green Vegetables, Wild Fruits, and Medicinal Plants with Potential Relevance for Kwashiorkor. [Journal Article]
- Evid Based Complement Alternat Med 2015.:807158.
Background.Inflammation, together with related oxidative stress, is linked with the etiology of kwashiorkor, a form of severe acute malnutrition in children. A diet rich in anti-inflammatory and antioxidant phytochemicals may offer potential for the prevention and treatment of kwashiorkor. We selected and assayed five leafy green vegetables, two wild fruits, and six medicinal plants from Kenya for their antioxidant and anti-inflammatory properties. Consensus regarding medicinal plant use was established from ethnobotanical data. Methods. Antioxidant activity and phenolic content were determined using the oxygen radical absorbance capacity (ORAC) assay and Folin-Ciocalteu procedure, respectively. Anti-inflammatory activity was assessed in vitro targeting the inflammatory mediator tumour necrosis factor-alpha (TNF-α).
Results.Mangifera indica (leaves used medicinally) showed the greatest antioxidant activity (5940 ± 632 µM TE/µg) and total phenolic content (337 ± 3 mg GAE/g) but Amaranthus dubius (leafy vegetable) showed the greatest inhibition of TNF-α (IC50 = 9 ± 1 μg/mL), followed by Ocimum americanum (medicinal plant) (IC50 = 16 ± 1 μg/mL). Informant consensus was significantly correlated with anti-inflammatory effects among active medicinal plants (r (2) = 0.7639, P = 0.0228).
Conclusions.Several plant species commonly consumed by Kenyan children possess activity profiles relevant to the prevention and treatment of kwashiorkor and warrant further investigation.
- Draft Genome Sequence of the Lactobacillus mucosae Strain Marseille. [Journal Article]
- Genome Announc 2015; 3(4)
- Draft Genome Sequence of the Lactobacillus agilis Strain Marseille. [Journal Article]
- Genome Announc 2015; 3(4)
- The Emerging Role of Cardiovascular Magnetic Resonance Imaging in the Evaluation of Metabolic Cardiomyopathies. [Journal Article]
- Horm Metab Res 2015 Aug; 47(9):623-32.
- Interventions Targeting Child Undernutrition in Developing Countries May Be Undermined by Dietary Exposure to Aflatoxin. [JOURNAL ARTICLE]
- Crit Rev Food Sci Nutr 2015 Jul 15.:0.
- Depression of neutrophil function followed by severe infection in a child with Marasmic Kwashiorkor. [Journal Article]
- Prilozi 2015; 36(1):191-5.
- Treatment Outcome of Severe Acute Malnutrition Cases at the Tamale Teaching Hospital. [Journal Article]
- J Nutr Metab 2015.:641784.
Objective.This study investigated the treatment outcomes and determinant factors likely to be associated with recovery rate. Methods. A retrospective chart review (RCR) was performed on 348 patients who were enrolled in the outpatient care (OPC) during the study period.
Results.Of the 348 cases, 33.6% recovered (having MUAC ≥125 mm), 49.1% defaulted, and 11.5% transferred to other OPC units to continue with treatment. There were 187 (53.7%) males and 161 (46.3%) females with severe malnutrition. The average weight gain rate was 28 g/kg/day. Controlling for other factors, patients who completed the treatment plan had 3.2 times higher probability of recovery from severe acute malnutrition (SAM) as compared to patients who defaulted (adjusted odds ratio (AOR) = 3.2, 95% CI = 1.9, 5.3, and p < 0.001). The children aged 24-59 months had 5.8 times higher probability of recovery from SAM as compared to children aged 6-11 months (AOR = 5.8, 95% CI = 2.5, 10.6, and p < 0.001).
Conclusions.Cure rate was low and the default rate was quite high. Children who were diagnosed as having marasmus on admission stayed longer before recovery than their kwashiorkor counterparts. Younger children were of greater risk of nonrecovery.
- Letter to the editor. Defence of my hypothesis that the oedema of kwashiorkor is caused by hypoalbuminaemia. [Comment, Letter]
- Paediatr Int Child Health 2015 May; 35(2):164.