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Mesothelioma, peritoneal [keywords]
- [Mesothelioma staging with (18)F-FDG PET/CT. A case report with simultaneous pleural and peritoneal infiltration.] [JOURNAL ARTICLE]
- Rev Esp Med Nucl Imagen Mol 2014 Jul 18.
- 0283 Mesothelioma incidence and occupation in the Nordic countries - a follow up during four decades. [Journal Article]
- Occup Environ Med 2014 Jun.:A100.
The purpose of this study was to study differences in incidence of malignant mesothelioma between the Nordic countries.We used data from the ongoing Nordic Occupational Cancer Study (NOCCA). Occupational title by 3-digit level was obtained from the countries' population and housing censuses in 1960, 1970, 1980 and 1990. A job-exposure matrix (JEM) was developed, including 25 carcinogens with specific exposure levels for 283 occupations for years 1945 to 1994, using national exposure databases and expert assessments. All mesothelioma cases (ICD-7 158 for peritoneum and 162.2 for pleura) in the Nordic countries 1961-2005 were identified through linkages with national cancer registers. We calculated Standardised Incidence Ratios (SIR) of mesothelioma for 53 occupations/occupational categories for men and women and linked with the NOCCA JEM.A total of 7899 persons were diagnosed with mesothelioma in the Nordic cohort from 1961 to 2005, of which 24.3% were women. There was an increased significant SIR of mesothelioma among 15 of the 53 occupations/occupational categories for men, and for nine different occupations for women. The men's excessed risk was observed in typical male-dominated occupations, highest for plumbers (SIR 4.64, 95% CI 4.09 to 5.24), with a total of 241 cases.We found great consistency among men between countries with occupations associated with asbestos exposure. For women, we found greater diversity between countries and risk assessment in occupations not associated with asbestos exposure. Unclear diagnosis of mesothelioma of the peritoneum and misclassification of occupation may be behind this.
- Well-differentiated papillary mesothelioma of the peritoneum: a diagnostic dilemma on fine-needle aspiration cytology. [Journal Article]
- Am J Clin Pathol 2014 Aug; 142(2):233-42.
Well-differentiated papillary mesothelioma of the peritoneum (WDPMP) is an uncommon subtype of epithelioid mesothelioma. Usually, WDPMP has a benign course, while a few patients have multiple recurrence and malignant transformation on long-term follow-up. The histology of WDPMP has been well studied compared with the cytology. Although accurate diagnosis is based only on histology and immunohistochemical stains, knowledge of the cytologic features of WDPMP in context with clinical and radiologic features is essential to predict a preoperative diagnosis and guide proper management, after excluding reactive mesothelial hyperplasia, malignant mesothelioma, and serous neoplasms of the ovaries and peritoneum. Surgical excision gives a favorable outcome.We describe a case of 28-year-old woman who sought treatment for chronic lower abdominal pain, dysuria, and dyspareunia.Radiologic findings suggested multiple metastatic peritoneal deposits. Ultrasound-guided fine-needle aspiration cytology showed many papillae, tubulopapillary and spheroid groups, monolayered pavement-like sheets, and many dispersed cells. Papillae showed many layers of round to ovoid cells, with minimal atypia. Atypical mitoses and necrosis were not found. A cytologic diagnosis of WDPMP was suggested. After complete resection of all the tumor nodules, histopathology and immunohistochemical findings were compatible with WDPMP. On follow-up, she developed tumor recurrence at 9 months and was managed successfully with adjuvant chemotherapy.This article highlights the cytologic features of WDPMP with relevant review of the literature and differential diagnosis.
- Malignant peritoneal mesothelioma in a child: chemotherapy with gemcitabine and platinum was effective for the disease unresponsive to other treatments. [JOURNAL ARTICLE]
- Anticancer Drugs 2014 Jul 9.
Malignant peritoneal mesothelioma in children is a very rare disease and has a poor prognosis. Unlike malignant mesothelioma in adults, there is no clear causal association between this very rare malignancy in children and asbestos exposure. We report a case of peritoneal mesothelioma in an 11-year-old boy who presented with ascites. He was diagnosed with malignant mesothelioma on the basis of histopathological findings. His disease showed resistance to pemetrexed, but was treated successfully with platinum-based therapy with gemcitabine. He has achieved long-term survival in partial remission with stable disease.
- [Clinical features of patients with malignant peritoneal mesothelioma initially presenting as a local inflammation]. [Journal Article]
- Zhonghua Zhong Liu Za Zhi 2014 Apr; 36(4):312-3.
- Health impact of the exposure to fibres with fluoro-edenitic composition on the residents in Biancavilla (Sicily, Italy): mortality and hospitalization from current data. [Journal Article]
- Ann Ist Super Sanita 2014; 50(2):127-32.
Introduction.The objective of this chapter is to study the health impact of the exposure to fibres with fluoro-edenitic composition on the residents in Biancavilla (Sicily, Italy), in terms of mortality and hospitalization. The diseases which international scientific literature indicates as associated with asbestos exposure were taken into consideration: mesothelioma of pleura, peritoneum, pericardium and tunica vaginalis testis, malignant neoplasm of larynx, malignant neoplasm of trachea, bronchus and lung, malignant neoplasm of ovary, pneumoconiosis; moreover, in order to describe the health profile of the study population, large groups of diseases were taken into consideration. Material and methods. Current data (available in the Data Bases of the Unit of Statistics of ISS) regarding mortality and hospitalization were analyzed. Standardized Mortality Ratios, Standardized Hospitalization Ratios and Age-standardized Death Rates were calculated. The demographic background of the population residing in Biancavilla was also outlined.
Conclusions.Our findings support the etiologic role of fibres with fluoro-edenitic composition in the occurrence of the above mentioned diseases, already observed in other studies.
- Epithelioid malignant mesothelioma presenting with features of gastric tumor in a child. [Journal Article]
- Int J Clin Exp Pathol 2014; 7(5):2636-40.
Localized malignant mesothelioma is very uncommon and mainly arises in pleura and peritoneum, and preferentially occurs in older adults. In this article, we report a case of a Localized malignant mesothelioma that was developed in the stomach of a 6-year-old boy. This boy was admitted to hospital for anemia. An epigastric mass was palpated through systemic physical examination and MR scanning demonstrated an 8×6 cm-sized, well-defined elliptic mass at gastric corpus. Partial resection of the stomach was performed for this boy and no nodules were found on the liver, peritoneum, and other abdominal sites in surgery. In view of the morphological and immunohistochemical findings, a diagnosis of localized malignant mesothelioma, epithelial type was made. This is the first case report of localized malignant mesothelioma arising in the stomach of a child. Accumulation of more cases of malignant mesothelioma involving gastrointestinal tract and longer follow-up of the patients are necessary to further characterize the features of this rare disease.
- Synchronous pleural and peritoneal malignant mesothelioma: a case report and review of literature. [Journal Article]
- Int J Clin Exp Pathol 2014; 7(5):2484-9.
The coexistence of mesothelioma and other primary malignancies has been previously reported in literature, but the finding of a pleural mesothelioma with a synchronous peritoneal mesothelioma has not been reported so far. We report a case of a 58-years-old woman that came to our attention for the incidental finding of an inguinal mass. Fine-needle biopsies of the mass and a thoracoscopy with pleural biopsies were performed, after imaging studies showed pleural thickenings suspicious for malignancy. Histological morphology and growth pattern were similar in both cases. Both tumors stained for calretinin, but only the pleural mesothelioma showed positivity for Wilms-Tumor 1 antibody. We tried to demonstrate with molecular biology techniques whether they were synchronous or one was the metastasis of the other, but our studies did not give informative results. The prognosis in this case is poor, and after 6 months the patient is still following a chemotherapy regimen, which is the only practicable approach given the extent of the disease.
- Short bowel syndrome after cytoreductive surgery and HIPEC: nutritional considerations. [Journal Article]
- J BUON 2014 Apr-Jun; 19(2):549-53.
Purpose:The aim of this study was to present a group of patients with <150 cm of small intestine after cytoreductive surgery (CRS)+hyperthermic intraperitoneal chemotherapy (HIPEC) and the special problems arising from this condition.
Methods:From November 2005 to November 2013, 130 patients were treated for peritoneal carcinomatosis (PC) with CRS+HIPEC. Ten patients (7.7%) were left with a short bowel due to anatomical and surgical reasons. All these patients were subjected to ileostomy. Four patients (40%) were treated for ovarian carcinoma, 4 (40%) for colon and appendiceal carcinoma, 1 for peritoneal mesothelioma and 1 patient for primary peritoneal carcinoma. The completeness of cytoreduction (CC) score was CC-0 in 4 patients (40%), CC-1 in 3 (30%) and CC-2 in 3 (30%).
Results:The mean length of the remaining small bowel was 105 cm (range 80-150). Mean hospitalization was 42 days vs 24 days in other patients with CRS+HIPEC (p<0.002). The daily ileostomy output increased between the 3rd to 4th week as a result of oral feeding and decreased at the 4th week due to somatostatin analogue administration and possible intestinal adaptation. The mean ileostomy output at 6 months was 810±100 ml vs 1590±210 ml the first month after CRS+HIPEC (p<0.001). The overall morbidity and mortality rate was the same as in patients without extensive resection. The impact of small bowel syndrome (SBS) on overall survival was very important, as the mean overall survival in the SBS group was 28.6 months vs 41 months in other CRS+HIPEC patients (p<0.001).
Conclusions:SBS is sometimes inevitable in order to perform optimal cytoreduction. Special management is required for these patients, including special nutritional efforts and home total parenteral nutrition (TPN). Extensive small bowel resection may constitute a contraindication in the management of peritoneal carcinomatosis.
- A case of unsuspected peritoneal mesothelioma occurring with colonic adenocarcinoma masquerading as peritoneal metastases. [Journal Article]
- Case Rep Pathol 2014.:838506.
We report a case of synchronous primary colonic adenocarcinoma and malignant mesothelioma. A 61-year-old male presented with a six-month history of fatigue and weight loss. An abdominal computed tomography (CT) scan showed a 5.8 cm partially obstructing mass in the cecum with ascites and peritoneal thickening. A biopsy of the large mass showed an adenocarcinoma. Because the patient was clinically thought to be a T4 colon carcinoma with peritoneal metastatic lesions (M1), prior to initiating chemotherapy, a debulking right hemicolectomy was performed. Resection of the colon and ileum revealed a T3N0 colonic mucinous adenocarcinoma and concurrent diffuse malignant peritoneal mesothelioma. Presenting synchronous colonic and peritoneal mesothelial primary malignancies are exceedingly rare but must be considered to prevent incorrect clinical staging.