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- A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus. [JOURNAL ARTICLE]
- Mol Microbiol 2016 Apr 28.
- Unnatural amino acid analogues of membrane-active helical peptides with anti-mycobacterial activity and improved stability. [JOURNAL ARTICLE]
- J Antimicrob Chemother 2016 Apr 26.
- Development of a web-based tool for automated processing and cataloging of a unique combinatorial drug screen. [JOURNAL ARTICLE]
- J Microbiol Methods 2016 Apr 23.
- Genetic signatures of Mycobacterium tuberculosis Nonthaburi genotype revealed by whole genome analysis of isolates from tuberculous meningitis patients in Thailand. [Journal Article]
- PeerJ 2016.:e1905.
- Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo. [JOURNAL ARTICLE]
- J Exp Med 2016 Apr 25.
- Encapsulation of zinc-rifampicin complex into transferrin-conjugated silver quantum-dots improves its antimycobacterial activity and stability and facilitates drug delivery into macrophages. [Journal Article]
- Sci Rep 2016.:24184.
- Characteristics and Treatment Outcomes of Retreatment Tuberculosis Patients in Benin. [Journal Article]
- Tuberc Res Treat 2016.:1468631.
Objective.To determine among retreatment tuberculosis patients in Benin baseline characteristics, culture, and drug sensitivity testing (DST) results and treatment outcomes. Materials and Methods. A retrospective national cohort study of all retreatment tuberculosis patients in Benin in 2013 using registers and treatment cards.
Results.Of 3957 patients with tuberculosis, 241 (6%) were retreatment cases. Compared to new pulmonary bacteriologically confirmed tuberculosis (NPBCT) patients, there were significantly higher numbers of males (P = 0.04), patients from "Atlantique-Littoral" (P = 0.006), patients aged 45-64 years (P = 0.007), and HIV-positive patients (P = 0.04) among those retreated. Overall, 171 (71%) patients submitted sputum for DST, of whom (163) 95% were positive for Mycobacterium tuberculosis on Xpert MTB/RIF and/or culture and 17 (10%) were rifampicin resistant (9 with MDR-TB and 8 monoresistant to rifampicin). For those without MDR-TB (n = 224), treatment success was 93%. Worse outcomes occurred in those with unknown HIV status (RR: 0.27; 0.05-1.45; P < 0.01) while better outcomes occurred in those who relapsed (RR: 1.06, 95 CI: 1.02-1.10, P = 0.04).
Conclusion.In 2013, a high proportion of retreatment patients received DST. Treatment success was good although more needs to be done to systematically increase the final follow-up smear examination. Reasons of high losses to follow-up from "Oueme-Plateau" should be investigated.
- Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis. [Journal Article]
- Nat Commun 2016.:11392.
- TB-HIV co-infection: a catastrophic comradeship. [Journal Article]
- Oral Dis 2016 Apr.:46-52.
- Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis. [REVIEW, JOURNAL ARTICLE]
- Adv Drug Deliv Rev 2016 Apr 21.