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(Mycobacterium tuberculosis AND drug use and)
24,841 results
  • Learning from the past for TB drug discovery in the future. [Review]
  • DDDrug Discov Today 2016 Oct 4
  • Mikušová K, Ekins S
  • Tuberculosis drug discovery has shifted in recent years from a primarily target-based approach to one that uses phenotypic high-throughput screens. As examples of this, through our EU-funded FP7 coll...
  • Whole genome sequencing of Mycobacterium tuberculosis for detection of drug resistance: a systematic review. [Review]
  • CMClin Microbiol Infect 2016 Sep 22
  • Papaventsis D, Casali N, … Nikolayevskyy V
  • CONCLUSIONS: Whole genome sequencing could be considered a promising alternative to existing phenotypic and molecular drug susceptibility testing methods for rifampicin and isoniazid pending standardization of analytical pipelines. To ensure clinical relevance of WGS for detection of M. tuberculosis complex drug resistance, future studies should include information on clinical outcomes.
  • Parallel reaction monitoring of clinical Mycobacterium tuberculosis lineages reveals pre-existent markers of rifampicin tolerance in the emerging Beijing lineage. [Journal Article]
  • JPJ Proteomics 2016 Aug 26; 150:9-17
  • de Keijzer J, Mulder A, … van Veelen PA
  • CONCLUSIONS: M. tuberculosis is the leading cause of death by a bacterial infection worldwide. Treatment-regimen to eradicate this pathogen make use of the first-line antibiotic rifampicin, which is considered to be the cornerstone of modern day anti-tuberculosis treatment. Despite the potency of rifampicin, there is an increasing occurrence of rifampicin resistant mutants in a specific cluster of M. tuberculosis, the Beijing genotype. Using both a data dependent acquisition and a targeted proteomic approach we identified markers of rifampicin tolerance to be high abundant in members of the M. tuberculosis Beijing genotype, already prior drug exposure. The identification of this M. tuberculosis Beijing specific trait will contribute to improved diagnostics and treatment of M. tuberculosis.
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