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(Neurology AND Movement disorders)
29,881 results
  • Incidence and time trends of drug-induced parkinsonism: A 30-year population-based study. [Journal Article]
  • MDMov Disord 2016 Oct 25
  • Savica R, Grossardt BR, … Rocca WA
  • CONCLUSIONS: The incidence of drug-induced parkinsonism increased with older age and was higher in women at all ages. Typical antipsychotic drugs were the most common cause. The incidence of drug-induced parkinsonism decreased over the 30 years of the study because of changes in drug use. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
  • Autosomal dominant Parkinson's disease: Incidence of mutations in LRRK2, SNCA, VPS35 and GBA genes in Brazil. [Journal Article]
  • NLNeurosci Lett 2016 Oct 21
  • Abreu GM, Valença DC, … Pimentel MM
  • CONCLUSIONS: Our findings in a representative series of index cases from families with ADPD emphasize the important contribution of LRRK2 G2019S and GBA (L444P and N370S) mutations to parkinsonism in Brazilian families. The absence of mutations in VPS35 and SNCA genes reveals that they are uncommon causes of PD in Brazil, corroborating previous studies that also failed to detect these genetic variants in PD patients from other populations. Recent discoveries of novel causative genes of autosomal dominant forms of PD expand the investigative possibilities and should be targeted on future studies.
  • Novel Levodopa Formulations for Parkinson's Disease. [Review]
  • CDCNS Drugs 2016; 30(11):1079-1095
  • Freitas ME, Ruiz-Lopez M, Fox SH
  • Levodopa remains the most effective treatment for Parkinson's disease and is considered the gold standard therapy. However, disease progression and changes in the gastrointestinal tract result in a d...
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