(Pulse pressure, wide) articles in PubMed
- The renin-angiotensin-aldosterone system (RAAS) - physiology and molecular mechanisms of functioning. [Journal Article]
- Postepy Hig Med Dosw (Online) 2016; 70(0):917-927PH
- Secretion of renin juxtaglomerular cells into bloodstream initiates activation of an enzymatic-hormonal cascade known as the RAAS (renin - angiotensin - aldosterone system). As a result, blood pressu...
Secretion of renin juxtaglomerular cells into bloodstream initiates activation of an enzymatic-hormonal cascade known as the RAAS (renin - angiotensin - aldosterone system). As a result, blood pressure is increased by the means several interrelated mechanisms. Mechanism of Zjednoczoaction of this system has been known for decades, but a few previously unknown components were recently added, such as ACE-2 and Ang(1-7), and their role often seems to be opposite to that of the conventional components. Local tissue systems also have important biological functions. They operate largely independently of the systemic activity, and their activity is observed primarily in the kidney, heart, in blood vessels, adrenal gland and nervous system. Angiotensin-2 (Ang-2), the main RAAS effector, has a wide scope of action, and thus abnormalities in its functioning have many consequences. Excessive activation is accompanied by chronic inflammation, as Ang-2 stimulates inflammatory mediators. As a result, degenerative processes and atherosclerosis are initiated. RAAS imbalance is associated with the most common diseases of civilization, such as cardio-vascular diseases, diabetes, kidney diseases, preeclampsia, osteoporosis and even neurodegenerative diseases. Many of these pathological processes are attributed to the excessive activation of tissue RA system. Therapeutic strategies based on inhibition of the RAAS are commonly used mainly in the treatment of hypertension and other cardiovascular disorders. The benefits of this class of drugs is primarily a decrease in blood pressure, but also the suppression of inflammatory processes and other pathological phenomena resulting from excessive activation of the RAAS. For that reason, some consider to use RAAS inhibitors in other diseases, e.g. Parkinson's disease. Further studies give hope for the improvement of RAAS inhibitor therapy and the development of new therapeutic strategies.
- How can the pressure in anti-embolism stockings be maintained during use? Laboratory evaluation of simulated 'wear' and different reconditioning protocols. [Journal Article]
- Int J Nurs Stud 2016 Sep 13; 64:19-24IJ
- CONCLUSIONS: Different brands of anti-embolism stockings exert different pressures on the same size of leg, when correctly fitted. The pressure exerted by anti-embolism stockings decreases with use but the correct pressure gradient is maintained if correctly fitted. Washing stockings after 24h of wear is effective in restoring their pressure delivering abilities and in some cases can surpass their 'as new' pressure delivering ability.
- High muscular fitness has a powerful protective cardiometabolic effect in adults: influence of weight status. [Journal Article]
- BMC Public Health 2016; 16(1):1012BP
- CONCLUSIONS: Participants with high MF/BM showed reduced cardiometabolic risk, which increased significantly when they were within normal parameters.
- The risk of cardiovascular side effects with anti-anginal drugs. [Journal Article]
- Expert Opin Drug Saf 2016 Sep 23EO
- CONCLUSIONS: Because of the different cardiac safety profiles and possible side effects, we recommend selection of initial drug or adjustment of therapy based on the resting heart rate; blood pressure, hemodynamic status; and resting left ventricular function, concomitant medications and any associated comorbidities.
- Whole-Body Vibration Exercise Therapy Improves Cardiac Autonomic Function and Blood Pressure in Obese Pre- and Stage 1 Hypertensive Postmenopausal Women. [Journal Article]
- J Altern Complement Med 2016 Sep 22JA
- CONCLUSIONS: WBV training for 8 weeks is an adequate unconventional exercise intervention for improving sympathovagal balance and BP in previously sedentary obese postmenopausal women.
- Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is associated with serum L-arginine levels. [Journal Article]
- Thromb Haemost 2016 Sep 22; 116(6)TH
- L-arginine is the essential precursor of nitric oxide, and is involved in multiple key physiological processes, including vascular and immune function. The genetic regulation of blood L-arginine leve...
L-arginine is the essential precursor of nitric oxide, and is involved in multiple key physiological processes, including vascular and immune function. The genetic regulation of blood L-arginine levels is largely unknown. We performed a genome-wide association study (GWAS) to identify genetic factors determining serum L-arginine levels, amongst 901 Europeans and 1,394 Indian Asians. We show that common genetic variations at the KLKB1 and F12 loci are strongly associated with serum L-arginine levels. The G allele of single nucleotide polymorphism (SNP) rs71640036 (T/G) in KLKB1 is associated with lower serum L-arginine concentrations (10 µmol/l per allele copy, p=1×10(-24)), while allele T of rs2545801 (T/C) near the F12 gene is associated with lower serum L-arginine levels (7 µmol/l per allele copy, p=7×10(-12)). Together these two loci explain 7 % of the total variance in serum L-arginine concentrations. The associations at both loci were replicated in independent cohorts with plasma L-arginine measurements (p<0.004). The two sentinel SNPs are in nearly complete LD with the nonsynonymous SNP rs3733402 at KLKB1 and the 5'-UTR SNP rs1801020 at F12, respectively. SNPs at both loci are associated with blood pressure. Our findings provide new insight into the genetic regulation of L-arginine and its potential relationship with cardiovascular risk.
- Homocysteine as Predictive Marker for Pregnancy-Induced Hypertension-A Comparative Study of Homocysteine Levels in Normal Versus Patients of PIH and Its Complications. [Journal Article]
- J Obstet Gynaecol India 2016; 66(Suppl 1):167-71JO
- CONCLUSIONS: Homocysteine levels have a direct statistical correlation with the severity of hypertension and complication with preeclampsia and eclampsia. It can be considered as a reliable predictive marker for PIH and its wide syndrome.
- The highly neglected burden of resistant hypertension in Africa: a systematic review and meta-analysis. [Journal Article]
- BMJ Open 2016; 6(9):e011452BO
- CONCLUSIONS: There is a huge dearth of research on the epidemiology of RH in Africa. Thereby, an extensive study of RH prevalence and risk factors is still largely warranted to curtail the high and continuously increasing burden of hypertension across Africa.
- OS 08-04 EPISTATIC AND SEX-DEPENDENT ASSOCIATION ANALYSES OF GENES OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM AND BLOOD PRESSURE IN FAMILIES. [Journal Article]
- J Hypertens 2016; 34 Suppl 1:e68-9JH
- CONCLUSIONS: Our analyses of SNPs in and around key RAAS genes for SBP reveal evidence of direct association, association dependent on sex and association dependent on epistasis. Variants dependent on epistasis or sex were not obvious in direct tests of association with SBP. Analyses that incorporate sex-dependent and epistatic effects could help account for the missing heritability of blood pressure.
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- OS 07-03 PRINCIPAL FINDINGS OF THE INVASIVE BLOOD PRESSURE META-ANALYSIS CONSORTIUM (INSPECT) ON THE ACCURACY OF BRACHIAL CUFF BLOOD PRESSURE DEVICES. [Journal Article]
- J Hypertens 2016; 34 Suppl 1:e65-6JH
- CONCLUSIONS: While recognising the clinical importance of BCUFF devices, there is wide variability in device accuracy for measuring intra-arterial BP. Although BCUFF devices are reasonable for correctly classifying BP at low and very high BP thresholds, more accurate BCUFF devices in the high-normal BP to grade II hypertension range should improve hypertension management.