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(Subutex) articles in PubMed
5,667 results
  • No evidence of potentiation of buprenorphine by milnacipran in healthy subjects using a nociceptive test battery. [Journal Article]
  • Eur J Pain 2016 Sep 21EJ
  • Okkerse P, Alvarez-Jimenez R, … Groeneveld GJ
  • CONCLUSIONS: Buprenorphine showed dose-dependent effects consistent with its pharmacological profile. Milnacipran alone did not affect any of the pain variables. The combination of both buprenorphine and milnacipran did not potentiate or show a synergistic effect on the pain models used in this study.Buprenorphine is known to be a potent opioid agonist. Animal studies suggest that milnacipran co-administered with opioids may potentiate the analgesic effect of μ-opioid receptor agonists. Here, we found that buprenorphine showed a dose-dependent analgesic effect, but that no potentiation or synergy on a battery of evoked pain tasks could be observed after co-administration of both milnacipran and buprenorphine.
  • Impact of early childhood trauma on retention and phase advancement in an outpatient buprenorphine treatment program. [Journal Article]
  • Am J Addict 2016; 25(7):542-8AJ
  • Kumar N, Stowe ZN, … Mancino MJ
  • CONCLUSIONS: The results from a convenience sample participating in a university-based buprenorphine treatment program demonstrated significant association between self-reported early childhood trauma and retention during the first 90 days. These findings suggest that addressing early trauma could potentially improve adherence rates leading to reduced disease burden. This study extends the knowledge base on potential predictive factors associated with successful participation in outpatient buprenorphine treatment. (Am J Addict 2016;25:542-548).
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