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- Seroprevalence of transfusion transmissible infections among blood donors at the blood bank of a Medical College of Kolkata. [Journal Article]
- Indian J Public Health 2014 Jan-Mar; 58(1):61-4.
Seroprevalence of transfusion transmissible infections (TTIs) among blood donors can be used to monitor the prevalence among apparently healthy adult population. The present study was conducted to determine the profile of blood donors and seroprevalence of TTI among them. Retrospective analysis of the donors of a blood bank attached with a tertiary care hospital of Kolkata in 2011 was carried out. Data were analyzed with SPSS version 17. Majority (85%) of the donors were male, two-third in the age group of 21-40 years. Among the donors 2.79% were positive for any of the screened TTIs. Seroprevalence was highest for hepatitis B (1.41%) followed by human immunodeficiency virus (0.60%) and hepatitis C (0.59%) and least for syphilis (0.23%). Seropositivity increased with age up to 50 years. There was no significant difference in seropositivity between male and female. Highly sensitive donor screening and public awareness program can make transfusion of blood products safe.
- [Factors associated with HIV and syphilis infection among men who have sex with men blood donors in Shenzhen]. [English Abstract, Journal Article]
- Zhonghua Yu Fang Yi Xue Za Zhi 2014 Feb; 48(2):128-32.
To investigate the distribution and factors associated with HIV and syphilis infection among Men who have sex with men blood donors (MSMBD) in Shenzhen.A total of 813 MSMBD were recruited using snowball sampling and respondent driven sampling from 2009 to 2012 in Shenzhen. Questionnaire-based interviews were conducted on a one-on-one basis. Data were collected including socio-demographic information, HIV testing history, self-identified sexual orientation, role in homosexual behavior, information about having sex with male sexual partners in the past six months and information about having sex with female sexual partners in the past six months.5 ml blood samples were taken and tested for treponema pallidum and HIV antibodies. Comparisons of syphilis and HIV infection among different years were analyzed by the Cochran-Armitage trend test. Factors associated with syphilis and HIV infection were analyzed by the univariate logistic regression and multivariate unconditional logistic regression.The prevalence of syphilis, HIV, and syphilis-HIV co-infection among 813 participants were 22.0% (179/813), 8.0% (65/813), and 4.2% (34/813), respectively. In the multivariate logistic regression analysis, ever tested for HIV (versus without HIV testing history, OR (95%CI) = 0.369(0.213-0.641)) will decrease the risk of HIV infection among MSMBD in comparison with never tested for HIV (OR (95%CI) = 0.37 (0.21-0.64) ); having five or more anal sexual partners in the past six months and co-infected with syphilis will increase the risk of HIV infection among MSMBD in comparison with having 0-1 sexual partners (OR (95%CI) = 2.04 (1.03-4.06) ) and negative syphilis (OR (95%CI) = 4.52(2.64-7.73)), respectively, bisexual orientation, having 2-4 anal sexual partners and having five or more anal sexual partners in the past six months, using condoms not for every act of anal sex, co-infected with HIV will increase the risk of syphilis infection among MSMBD in comparison with homosexual orientation (OR (95%CI) = 1.60(1.12-2.27)), having 0-1 sexual partner in the past six months (OR (95%CI) = 1.77 (1.09-2.87) and OR (95%CI) = 1.84(1.09-3.08) ) , using condoms for every act of anal sex (OR (95%CI) = 1.61 (1.10-2.36) ) and negative HIV (OR (95%CI) = 4.02 (2.33-6.96)), respectively.The prevalence of HIV and syphilis among MSMBD in Shenzhen are much higher with complex influence factors. The relevant government should pay great attention to it and ensure the blood safety.
- Complete Genome Sequence of the Treponema pallidum subsp. pallidum Sea81-4 Strain. [Journal Article]
- Genome Announc 2014; 2(2)
Using the rabbit model of syphilis, the Sea81-4 strain of Treponema pallidum subsp. pallidum has been found to be more likely than other strains to invade the central nervous system (CNS). To identify possible explanations for this important phenotype at the genomic level, we sequenced the Sea81-4 strain genome.
- Syphilis and Its Correlates among Heterosexual Males Attending Sexually Transmitted Infection Clinics - Observation from a Multicity Cohort in Jiangsu Province, China. [Journal Article]
- PLoS One 2014; 9(4):e95289.
To estimate the prevalence of HIV and syphilis, incidence of syphilis and to identify the correlates of syphilis infection among heterosexual male attendees of sexually transmitted infection (STI) clinics (MSC).A cohort study of one-year duration was conducted in Yangzhou and Changzhou cities in Jiangsu province of China. The baseline survey commenced in June 2009, recruited 1225 consenting adult MSCs (609 in Yangzhou and 617 in Changzhou) through STI-clinic based convenience sampling.Baseline HIV and syphilis prevalence were 0.49% and 17.29% respectively. Syphilis incidence rate was 7.22 per 100 person-years (6.53 in Yangzhou and 7.76 in Changzhou) during the 6-month follow-up with retention fractions of 27.38% and 35.15% for Yangzhou and Changzhou respectively. Majority of the participants were middle-aged, high school educated, married, living with partners and non-migrants. Very few subjects reported recent and consistent condom-use with regular partners. Although considerable number of MSCs reported recent sexual exposure with female sex workers (FSW) and non-FSW casual partners, the proportion of reported condom use was very low during those exposures. In multivariate analyses higher age, having recent sex with FSWs and being HIV-positive were associated with higher syphilis sero-positivity while higher education was protective. In bivariate analyses, being married, divorced/widowed, official residency of the study cities and non-use of condom with regular partners predicted higher risk.Considering the potential bridging role of MSCs between high and low-risk populations, effective intervention strategies among them targeting the correlates of syphilis infection are urgently called for in Jiangsu province of China.
- [Analysis of spreading the sexually transmitted disorders in georgia]. [English Abstract, Journal Article]
- Georgian Med News 2014 Mar; (228):55-9.
According statistical data in Georgia sexually transmitted disorders represent one of the most important medical and social problems. Main causes of this are hard social and economic condition of the country, changing sexual-behavioral stereotypes, drugs and alcohol abuse, political perturbation, as well as unprecedented decrease in financing prevention programs of STD by government. The purpose of given research is statistical analysis of spread of sexually transmitted disorders in Georgia, in particular, among the people included in risk group; finding trends and in accordance with this, working out recommendations for improvement of situation in given field of medicine. Essays showed that through 2000-2012 years among STD revealed in the group of increased risk chlamidiosis was the most common. There is an objective trend of increasing the level of morbidity with chlamidiosis and trichomoniasis, however the speed of increasing morbidity with trichomoniasis probably does not correspond the reality. In the same time morbidity with gonorrhea and syphilis is decreasing, however in the result of significant decrease in STD prevention program scale data validity concerning syphilis might be doubtful. Coming out of this in the field of health care related to STD optimization of laboratory diagnostics management is essential; perfection of methods of epidemiologic control; increasing the scales of prevention programs as well as initiation of researches related to antimicrobial resistance of gonococci. Authors consider essential taking steps for optimization of management of laboratory diagnostics and perfection of methods of epidemiologic control and increasing scales of preventive programs.
- [Study on the characteristics of serology and sexual behavior among drug users at the HIV sentinel surveillance sites in 2012]. [English Abstract, Journal Article]
- Zhonghua Liu Xing Bing Xue Za Zhi 2014 Feb; 35(2):121-3.
To analyze the serological results and sexual behavior among different types of drug users (DUS) at the HIV sentinel surveillance sites.Sentinel surveillance programs were conducted between April and June annually. DUS were those involved in custodies, living at the communities and those attending the methadone maintenance treatment clinics but with positive urine tests one month before blood sampling collected and questionnaire survey started.116 279 drug abusers were included in the analysis. The prevalence rates of HIV, Syphilis and HCV among traditional drug (heroin, etc.)users were 5.0%, 4.4% and 49.4%, while the prevalence rates of new narcotic (meth, etc.) users were 0.5%, 4.6%, 15.2%, respectively. The prevalence rates of HIV, syphilis among traditional drug uses were higher than the new narcotic users (P < 0.01). The proportion of sexual behavior in last month and the proportion of sexual behavior with casual and commercial sexual partners were 46.3%, 87.2% and 28.1% among the new narcotic users, respectively, which were higher than those among traditional drug users (40.7% , 82.8% and 22.2%). The proportion of using condom in last sexual contact with casual sexual partner was 33.3% among the new narcotic users which was less than traditional drug users (36.2%). The proportion of condom use in the last commercial sexual contact was 65.1% which was higher than those traditional drug users (62.9%). The proportion of never using condom with casual and commercial sexual partners in the past year was 43.2% and 19.0% among the traditional drug users, which were higher than those among new narcotic users (41.3%, 15.3%).Compared with the traditional drug abusers, the sexual behavior of new narcotic users seemed more active, less engaging in condom use but with higher risk of HIV transmission through sexual contact.
- Factors associated with HIV and syphilis co-infection among men who have sex with men in seven Chinese cities. [JOURNAL ARTICLE]
- Int J STD AIDS 2014 Apr 15.
HIV-syphilis co-infection is often cited as a major reason behind recent resurgence in syphilis prevalence among men who have sex with men in China. Most published literatures explore factors associated with either HIV or syphilis, but not their co-infection. We analysed data from a cross-sectional survey on men who have sex with men in seven Chinese cities. Snowball sampling was used to recruit participants for the survey. Socio-demographic and behavioral predictors for HIV-syphilis mono/co-infection were examined using ordinal logistic regression. Factor scores were used to summarise (1) HIV-related knowledge and (2) access to HIV preventive services. Prevalence of HIV, syphilis, and their co-infection, among 2936 self-identified men who have sex with men, were 7.7%, 14.3%, and 2.6%, respectively. In the adjusted analysis, the significant positive correlates of poorer diagnoses (co-infection vs mono- and no infection or co- and mono-infection vs no infection) were -30 to 39 years and ≥40 years age, education up to senior high school, unprotected anal intercourse, recent sexually transmitted disease symptoms, incorrect knowledge about routes of transmission, and access to preventive or counselling/testing services for HIV. For effective control of this dual epidemic, integrated HIV and syphilis surveillance and targeted intervention strategies for Chinese men who have sex with men are need of the hour.
- HIV Risk Perception and Behavior among Sex Workers in Three Major Urban Centers of Mozambique. [Journal Article]
- PLoS One 2014; 9(4):e94838.
HIV risk perceptions and behaviors of 236 commercial sex workers from three major Mozambican urban centers were studied using the International Rapid Assessment, Response and Evaluation (I-RARE) methodology. All were offered HIV testing and, in Maputo, syphilis testing was offered as well. Sixty-three of the 236 opted for HIV testing, with 30 (48%) testing positive for HIV. In Maputo, all 30 receiving HIV tests also had syphilis testing, with 6 (20%) found to be positive. Results include interview excerpts and qualitative results using I-RARE methodology and AnSWR-assisted analyses of the interviews and focus group sessions.
- Defining research priorities for bacterial sexually transmitted infections in Canada. [Journal Article]
- Can J Public Health 2014; 105(1):e86-90.
We aimed to define priority areas for research on chlamydia, gonorrhea, and syphilis in Canada through the use of a consensus method.A modified Delphi method was conducted, consisting of two online surveys and an in-person meeting. Participants included people working in bacterial sexually transmitted infections (STIs) across Canada, including clinicians, policy-makers, public health practitioners, and researchers.Consensus was achieved regarding the most important priority topics in bacterial STI research in Canada, within five general priority areas: the epidemiology of bacterial STIs, screening, partner notification and contact tracing, antimicrobial resistance, and identification of best practices for the prevention and control of bacterial STIs.The findings of this consensus process can be used to inform research efforts, which could contribute to more effective control of bacterial STIs in Canada.
- Prevalence and risk factors associated with HIV infection, hepatitis and syphilis in a state prison of Sao Paulo. [JOURNAL ARTICLE]
- Int J STD AIDS 2014 Apr 14.
Given the importance of the control of sexually transmitted infections in the general population and specifically in the prison system, we rolled out this cross-sectional study in 2007. Standard questionnaires and blood samples were accessed among 680 prisoners. Protocol was approved by the Ethics Committee. Results: The prevalence: HIV, 1.8% (IC95% = 0.1-3.3); HBV, 21.0% (IC95% = 17.8-25.1); HBV, 5.3% (IC95% = 3.5-7.6) and syphilis 5.3% (IC95% = 3.5-7.6). Logistic regression identified association (p < 0.05): HIV: injectable drug use (OR = 15.4), over 30 years (OR = 13.3), cocaine use (OR = 5.4) and crack-cocaine use (OR = 5.2); HBV: injectable drug use (OR = 3.4), reference to previous sexually transmitted infection (OR = 2.3), over 30 years (OR = 1.9) and more than 5 years in prison (OR = 2.2); HCV: injectable drug use (OR = 9.65), marijuana use in prison (OR = 2.9) and more than 30 years (OR = 8.4) and for syphilis: homosexual relationship (OR = 7.8) and previous syphilis reported (OR = 7.7). These prevalences remain high when compared to the general population, however, HIV infection tended to decrease in prisoners while the other studied infections remained unchanged. Preventive actions to reduce sexual and parenteral risk have been advocated. However, measures capable of controlling these infections still have not made an impact.