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(TMP) articles in PubMed
4,579 results
  • Pharmacoepigenetics of the role of DNA methylation in μ-opioid receptor expression in different human brain regions. [Journal Article]
  • Epigenomics 2016 Sep 29E
  • Knothe C, Oertel BG, … Lötsch J
  • CONCLUSIONS: While high or low μ-opioid receptor expression significantly correlated with local OPRM1 mRNA levels, there was no corresponding association with OPRM1 methylation status. Additional experiments in human cell lines showed that changes in DNA methylation associated with changes in μ-opioid expression were an order of magnitude greater than differences in brain. Hence, different degrees of DNA methylation associated with chronic opioid exposure are unlikely to exert a major role in the region-specificity of μ-opioid-receptor expression in the human brain.
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