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1,329 results
  • Structural Analysis of the Histamine H1 Receptor. [Journal Article]
  • HEHandb Exp Pharmacol 2016 Nov 09
  • Shiroishi M, Kobayashi T
  • The crystal structure of the human histamine H1 receptor (H1R) has been determined in complex with its inverse agonist doxepin, a first-generation antihistamine. The crystal structure showed that dox...
  • Review of Safety and Efficacy of Sleep Medicines in Older Adults. [Review]
  • CTClin Ther 2016; 38(11):2340-2372
  • Schroeck JL, Ford J, … Mergenhagen KA
  • CONCLUSIONS: An ideal treatment for insomnia should help to improve sleep latency and sleep duration with limited awakenings and be without significant adverse effects such as daytime somnolence or decreased alertness. Cognitive behavioral therapy should always be first line treatment. Clinical inertia regarding previous prominent use of benzodiazepines and non-BzRAs will be a significant challenge for patients accustomed to their issuance. The future direction of insomnia treatment should have an emphasis on nonpharmacologic interventions, treating comorbid conditions, and focusing therapy on using benzodiazepines and non-BzRAs as last resorts.
  • Psychogenic Itch Management. [Journal Article]
  • CPCurr Probl Dermatol 2016; 50:124-32
  • Szepietowski JC, Reszke R
  • Pruritus is a bothersome and prevalent symptom reported by patients suffering from both cutaneous and extracutaneous diseases. Psychogenic pruritus, also referred to as functional itch disorder, is a...
  • Neurologic Itch Management. [Journal Article]
  • CPCurr Probl Dermatol 2016; 50:116-23
  • Şavk E
  • Neurologic itch is defined as pruritus resulting from any dysfunction of the nervous system. Itch arising due to a neuroanatomic pathology is seen to be neuropathic. Causes of neuropathic itch range ...
  • Itch in Psoriasis Management. [Journal Article]
  • CPCurr Probl Dermatol 2016; 50:102-10
  • Szepietowski JC, Reich A
  • Psoriasis is a common chronic inflammatory skin disease observed in about 1-3% of the general population. About 60-90% of patients with psoriasis suffer from itching. Interestingly, in the past itch ...
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