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(acetylcholine chloride) articles in PubMed
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  • A Novel Tobacco Use Phenotype Suggests the 15q25 and 19q13 Loci May Be Differentially Associated with Cigarettes per Day and Tobacco-Related Problems. [Journal Article]
  • Nicotine Tob Res 2016 Sep 23NT
  • Richmond-Rakerd LS, Otto JM, … Gizer IR
  • CONCLUSIONS: CPD captures variation at 15q25. Although strong conclusions cannot be drawn, these finding suggest measuring additional dimensions of problems may detect genetic variation not accounted for by smoking quantity. Replication in independent samples will help further refine phenotype definition efforts.Different facets of tobacco-related problems may index unique genetic risk. Cigarettes per day, a simple measure of tobacco consumption, is associated with variants at the 15q25 gene cluster. Additional dimensions of tobacco problems may help to capture variation at 19q13. Results demonstrate the utility of adopting a data-driven approach to defining phenotypes for genetic association studies of tobacco involvement and provide results that can inform replication efforts.
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