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- Post-operative Analgesia in Opioid Dependent Patients: Comparison of Intravenous Morphine and Sublingual Buprenorphine. [Journal Article]
- Addict Health 2015 Winter-Spring; 7(1-2):60-5.
- Pharmacological Management of Opioid Use Disorder in Pregnant Women. [JOURNAL ARTICLE]
- CNS Drugs 2015 Aug 28.
- Sleep-disordered breathing in patients with opioid use disorders in long-term maintenance on buprenorphine-naloxone: A case series. [Journal Article]
- J Opioid Manag 2015 Jul-Aug; 11(4):363-6.
- Triple dosing with high doses of buprenorphine: Withdrawal and plasma concentrations. [Journal Article]
- J Opioid Manag 2015 Jul-Aug; 11(4):319-24.
- Effects of premedication with sustained-release buprenorphine hydrochloride and anesthetic induction with ketamine hydrochloride or propofol in combination with diazepam on intraocular pressure in healthy sheep. [Journal Article]
- Am J Vet Res 2015 Sep; 76(9):771-9.
OBJECTIVETo determine the effects of diazepam combined with ketamine hydrochloride or propofol for induction of anesthesia (IOA) following premedication with sustained-release buprenorphine hydrochloride (SRB) on intraocular pressure (IOP) in sheep. ANIMALS 20 healthy adult sheep. PROCEDURES Diazepam with ketamine or propofol was given IV to each of 10 sheep after premedication with SRB (0.01 mg/kg, SC); after > 4 weeks, each sheep received the other induction combination with no premedication. For both eyes, IOPs were measured before premedication (if given), 10 minutes prior to (baseline) and immediately following administration of ketamine or propofol (time of IOA), after endotracheal intubation, and 5 minutes after IOA. Peak end-tidal Pco2, globe position, and pupillary diameter were also analyzed.
RESULTSData were not available for all sheep for all anesthetic episodes. Propofol-diazepam administration alone had no significant effect on IOP, whereas there was a significant decrease in IOP immediately following ketamine-diazepam administration alone. At 5 minutes after ketamine-diazepam administration, SRB-premedicated sheep had significantly higher IOP than unpremedicated sheep. Intraocular pressure was significantly higher at baseline, at intubation, and 5 minutes after IOA in SRB-premedicated sheep receiving propofol-diazepam, compared with unpremedicated sheep. Peak end-tidal Pco2 at intubation was significantly higher in SRB-premedicated sheep. For sheep receiving either anesthetic treatment, IOPs did not differ significantly with or without SRB premedication. Globe position or pupillary diameter and IOP were not significantly related at any time point.
CONCLUSIONSAND CLINICAL RELEVANCE Results suggested that both ketamine-diazepam and propofol-diazepam combinations were suitable for IOA without increasing IOP in sheep. The use of SRB should be avoided in sheep when increases in IOP are undesirable.
- Opioid Dependence Treatment in the Emergency Department--Reply. [Comment, Letter]
- JAMA 2015 Aug 25; 314(8):835.
- Opioid Dependence Treatment in the Emergency Department. [Comment, Letter]
- JAMA 2015 Aug 25; 314(8):834-5.
- Buprenorphine infrequently found in fatal overdose in New York City. [JOURNAL ARTICLE]
- Drug Alcohol Depend 2015 Aug 15.
- Pain Volatility and Prescription Opioid Addiction Treatment Outcomes in Patients With Chronic Pain. [JOURNAL ARTICLE]
- Exp Clin Psychopharmacol 2015 Aug 24.
- Engagement and substance dependence in a primary care-based addiction treatment program for people infected with HIV and people at high-risk for HIV infection. [JOURNAL ARTICLE]
- J Subst Abuse Treat 2015 Jul 21.