- Rapid Occurrence of Chronic Kidney Disease in Patients Experiencing Reversible Acute Kidney Injury after Cardiac Surgery. [Journal Article]
- AAnesthesiology 2016 Oct 17
- CONCLUSIONS: The authors' data consolidate the recent paradigm shift, reporting acute kidney injury as a strong risk factor for the rapid development of chronic kidney disease.
- OS 04-06 HOW TO CONTROL HIGH BLOOD PRESSURE AFTER CORONARY REVASCULARIZATION IN PATIENTS REFERRED TO IN- HOUSE CARDIAC REHABILITATION? SINGLE CENTER EXPERIENCE. [Journal Article]
- JHJ Hypertens 2016; 34 Suppl 1 - ISH 2016 Abstract Book:e56
- CONCLUSIONS: CABG and stent can help to restore blood flow to an area of the heart. However, they do not stop the progression of atherosclerosis. High blood pressure can be successfully detected and treated during in house supervised cardiac rehabilitation program.
- SY 06-3 ROLE OF SURGICAL TREATMENT OF MORBID OBESITY. [Journal Article]
- JHJ Hypertens 2016; 34 Suppl 1 - ISH 2016 Abstract Book:e20
- Obesity is a pan-endemic health problem in both developed and developing countries, in both western and eastern countries. It increases risk for many common diseases, including type 2 diabetes, dysli...
Obesity is a pan-endemic health problem in both developed and developing countries, in both western and eastern countries. It increases risk for many common diseases, including type 2 diabetes, dyslipidemia, hypertension, obstructive sleep apnea, heart disease, stroke, asthma, osteoarthritis, cancers and depression etc.. Although the incidence of obesity in Asia is relatively low, Asian patients tend to have similar incidence of obesity related metabolic syndrome at lower BMI level comparing to Caucasians because of central obesity. Hypertension increased with increasing BMI but not with increasing age or waist wideness. On the contrary, the prevalence of hyperglycemia, dyslipidemia increased with increasing waist and age.There are strong evidences that bariatric surgeries can cure most of the associated co-morbidities, improve life quality and prolong survival in morbidly obese patients. In average, diabetes was completely resolved or improved in 86.0%, hyperlipidemia in 70%, obstructive sleep apnea in 85.7% and hypertension in 78.5%. Adjusted odds ratios for the surgically treated group versus controls were 0.8 for hypertension, 0.002 for diabetes and 0.028 for LDL.Recently developed laparoscopic surgery has renewed the interest and reimbursed the growth of laparoscopic bariatric surgery. In Asia, laparoscopic obesity surgery has also gained a substantial progress in the past decade. Among the current surgical procedures, laparoscopic sleeve gastrectomy and gastric bypass are the two most commonly performed procedures. Laparoscopic sleeve gastrectomy is increasingly being performed as a standalone bariatric procedure. With the advantage of easier technique, lower mortality rate, rapid weight loss and less long-term complication, this procedure is the most welcomed in Asia now. Laparoscopic duodenal switch is recommended for super-morbid obesity. Some new procedures and many non-operative trans-oral procedures have been developed for the treatment of obesity.In conclusion, laparoscopic bariatric surgery is the recommended treatment for morbid obese patients. Effective weight loss was achieved after surgery and a substantial majority of patients with diabetes, hyperlipidemia, hypertension, and obstructive sleep apnea experienced complete resolution or improvement.
- Implementation of the Spanish National Enhanced Recovery Program (ERAS) in Bariatric Surgery: A Pilot Study. [Journal Article]
- SLSurg Laparosc Endosc Percutan Tech 2016 Oct 7
- CONCLUSIONS: The Spanish National ERAS protocol is a safe issue with a high implementation rate. It can be recommended to establish this protocol to other institutions.
- Trends in rates, patient selection and prognosis of coronary revascularisations in Finland between 1994 and 2013: the CVDR. [Journal Article]
- EEuroIntervention 2016 Oct 20; 12(9):1117-1125
- CONCLUSIONS: Although revascularisation patients are older than before, post-procedural prognosis has improved drastically in recent years. Understanding the changing characteristics and prognosis of these patients is important for the interpretation of previous and future studies.
- PCNA-Ub polyubiquitination inhibits cell proliferation and induces cell-cycle checkpoints. [Journal Article]
- CCCell Cycle 2016 Oct 18; :0
- In response to replication-blocking lesions, proliferating cell nuclear antigen (PCNA) can be sequentially ubiquitinated at the K164 residue leading to two modes of DNA-damage tolerance, namely trans...
In response to replication-blocking lesions, proliferating cell nuclear antigen (PCNA) can be sequentially ubiquitinated at the K164 residue leading to two modes of DNA-damage tolerance, namely translesion DNA synthesis (TLS) and error-free lesion bypass. Ectopic expression of PCNA fused with ubiquitin (Ub) lacking the two C-terminal Gly residues resembles PCNA monoubiquitination-mediated TLS. However, if the fused Ub contains C-terminal Gly residues, it is further polyubiquitinated and inhibits cell proliferation. Unexpectedly, the polyubiquitination chain does not require any surface Lys residues and is likely to be head-to-tail linked. Such PCNA polyubiquitination interferes with replication, arrests cells at the S-phase and activates the p53 checkpoint pathway. The above cell-cycle arrest is reversible in an ATR-dependent manner, as simultaneous inhibition of ATR, but not ATM, induces apoptosis. Since ectopic expression of PCNA-Ub also induces double-strand breaks that colocalize with single-stranded DNA, we infer that this non-canonical PCNA poly-Ub chain serves as a signal to activate ATR checkpoint and recruit double-strand-break repair apparatus.
- Tumor Promoting Aspects of Senescence in Cancer Progression. [Journal Article]
- CICancer Invest 2016 Oct 18; :1-7
- Cancers induced by gene mutation, deletion, and genome instability might be related to aging. With similar pathways of aging but distinct functions, senescence at the cellular level is an irreversibl...
Cancers induced by gene mutation, deletion, and genome instability might be related to aging. With similar pathways of aging but distinct functions, senescence at the cellular level is an irreversible arrest of cell cycle. Senescence has long been believed as a barrier to restrict tumor expansion. However, more and more evidence has been shown that senescence inducers regulate epithelial-mesenchymal transition, stem cell self-renewal, inflammatory response, crosstalk with the oncogenic bypass signaling, and conversion of oncogene to tumor suppressor. Here we will discuss the most recent findings of the oncogenic aspects of senescence which crosstalk with multiple pathways in cancer progression.
- Full Mimicking of Coronary Hemodynamics for Ex-Vivo Stimulation of Human Saphenous Veins. [Journal Article]
- ABAnn Biomed Eng 2016 Oct 17
- After coronary artery bypass grafting, structural modifications of the saphenous vein wall lead to lumen narrowing in response to the altered hemodynamic conditions. Here we present the design of a n...
After coronary artery bypass grafting, structural modifications of the saphenous vein wall lead to lumen narrowing in response to the altered hemodynamic conditions. Here we present the design of a novel ex vivo culture system conceived for mimicking central coronary artery hemodynamics, and we report the results of biomechanical stimulation experiments using human saphenous vein samples. The novel pulsatile system used an aortic-like pressure for forcing a time-dependent coronary-like resistance to obtain the corresponding coronary-like flow rate. The obtained pulsatile pressures and flow rates (diastolic/systolic: 80/120 mmHg and 200/100 mL/min, respectively) showed a reliable mimicking of the complex coronary hemodynamic environment. Saphenous vein segments from patients undergoing coronary artery bypass grafting (n = 12) were subjected to stimulation in our bioreactor with coronary pulsatile pressure/flow patterns or with venous-like perfusion. After 7-day stimulation, SVs were fixed and stained for morphometric evaluation and immunofluorescence. Results were compared with untreated segments of the same veins. Morphometric and immunofluorescence analysis revealed that 7 days of pulsatile stimulation: (i) did not affect integrity of the vessel wall and lumen perimeter, (ii) significantly decreased both intima and media thickness, (iii) led to partial endothelial denudation, and (iv) induced apoptosis in the vessel wall. These data are consistent with the early vessel remodeling events involved in venous bypass adaptation to arterial flow/pressure patterns. The pulsatile system proved to be a suitable device to identify ex vivo mechanical cues leading to graft adaptation.
- Outcomes following 50 consecutive endoscopic gastrojejunal revisions for weight gain following Roux-en-Y gastric bypass: a comparison of endoscopic suturing techniques for stoma reduction. [Journal Article]
- SESurg Endosc 2016 Oct 17
- CONCLUSIONS: Endoscopic revision of the gastric outlet results in meaningful weight loss and comorbidity resolution in select patients experiencing weight regain following RYGB. A PST revision likely results in higher and more sustainable weight loss when compared to IRT.
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- Revascularisation of patients with end-stage renal disease on chronic haemodialysis: bypass surgery versus PCI-analysis of routine statutory health insurance data. [Journal Article]
- OHOpen Heart 2016; 3(2):e000464
- CONCLUSIONS: In this cohort of unselected patients with ESRD undergoing revascularisation, the 1-year outcome was better for CABG in patients with and without AMI. The 30-day mortality was higher in non-AMI patients with CABG reflecting an early hazard with surgery. In cases where the patient's characteristics and risk profile make it difficult to decide on a revascularisation strategy, CABG could be the preferred option.