(ideal body weight)
- One-year follow-up of blood viscosity factors and hematocrit/viscosity ratio in elite soccer players. [Journal Article]
- CHClin Hemorheol Microcirc 2016 Oct 15
- We investigated to what extent a prediction of the 'ideal' hematocrit based on individual hemorheological profile with an equation of viscosity is relevant in trained athletes, and how the agreement ...
We investigated to what extent a prediction of the 'ideal' hematocrit based on individual hemorheological profile with an equation of viscosity is relevant in trained athletes, and how the agreement between theoretical and actual values is modified by changes in training volume and performance. Elite soccer players (national level: 18-32 yr, weight 61-83 kg, body mass index 20.9-25.8 kg/m2) were seen twice at one year interval. Hemorheologic parameters were measured with the MT90 viscometer and the Myrenne aggregometer the theoretical bell-shaped curve of hematocrit/viscosity ratio as a function of hematocrit was reconstructed with Quemada's equation using actual plasma viscosity and red cell rigidity to predict hematocrit/viscosity at various hematocrit levels. RBC aggregation is correlated at baseline with fat mass (M1 = 0.552 p < 0.02) and changes in aggregation are related to changes in fat mass (M = 0.652, p < 0.05; M1 = 0.647, p < 0.05). Predicted and actual hematocrit are correlated (r = 0.644, p < 0.05) but exhibit discrepancies (mean difference -1% range [3.24 to 1.24]) and those discrepancies are inversely correlated to the level of predicted hematocrit (r = -0.912, p < 0.01), to systolic blood pressure (r = -0.626, p < 0.05), and to the overtraining score (r = -0.693, p < 0.05). After one year changes in hematocrit are a close reflect of the change in training volume (r = -0.877, p < 0.01) but are not correlated to fitness changes. Therefore in these athletes i) systemic hematocrit is close to its predicted 'ideal value", suggesting the accuracy of the prediction; ii) red cell aggregation is correlated to fat mass even in nonobese subjects; iii) hematocrit is lower than predicted by the model when markers of sympathetic tone (systolic blood pressure, overtraining score) are increased; iv) weekly training volume appears the main determinant of the reduction of hematocrit.
- « Optimal » vs actual hematocrit in obesity and overweight. [Journal Article]
- CHClin Hemorheol Microcirc 2016 Oct 15
- Equations of blood viscosity provide a prediction of the 'optimal' hematocrit' (hct) as the hct resulting in the highest value of the bell-shaped curve of hematocrit/viscosity ratio h/η. We investiga...
Equations of blood viscosity provide a prediction of the 'optimal' hematocrit' (hct) as the hct resulting in the highest value of the bell-shaped curve of hematocrit/viscosity ratio h/η. We investigated if overweight and obesity have an influence on these parameters. We compared 32 normal weight subjects, 40 overweight (BMI 25-30) and 38 obese subjects. There was no difference in the theoretical curve of h/η. The actual h/η is the same in the 3 groups but is always higher than the theoretical h/η in all groups. The actual h/η is lower in overweight than controls (p = 0.011). Modeling yields the same value of theoretical optimal hct across BMI classes. The 3 groups have the same values of actual hct, but actual is significantly lower than optimal in all cases (p < 0.001). Hematocrit is lower than predicted due to a discrepancy between predicted and actual h/η which is due to the inter-subject variability of RBC rigidity ... The discrepancy between optimal and actual h/η is negatively correlated to RBC rigidity indexes even if the model uses a fixed value of these indexes. Thus keeping in mind that the optimal hct should not be the same in the various parts of the vascular bed, its theoretical prediction with Quemada's equation appears to predict a value higher than actual hematocrit but well correlated to it, and the agreement between optimal and actual hct is dependent on RBC flexibility. This leads to think that the body sets hematocrit below its ideal value in sedentary subjects in order to cope with the need of increasing blood viscosity factors in case of exercise without impairing O2 supply to tissues.
- In vivo assessment of subcutaneous fat in dogs by real-time ultrasonography and image analysis. [Journal Article]
- AVActa Vet Scand 2016 Oct 20; 58(Suppl 1):58
- CONCLUSIONS: Preliminary data showed that within this population there was a strong correlation between BCS and SFT estimated from RTU images. It was also observed that RTU measurements for fat thickness differed among the anatomical points surveyed suggesting differences in their sensitivity to a change in BCS. The images displaying the best prediction value for fatness variations were those collected at the lumbar and abdomen areas.
- The clinical and economic impact of the use of diabetes-specific enteral formula on ICU patients with type 2 diabetes. [Journal Article]
- CNClin Nutr 2016 Oct 6
- CONCLUSIONS: The use of DSF in ICU patients with T2D is correlated with significant reduction in mortality and improved health economic outcomes.
- Effect of dietary lysine on performance and expression of electron transport chain genes in the pectoralis major muscle of broilers. [Journal Article]
- AAnimal 2016 Oct 21; :1-6
- The aim of this study was to evaluate the effect of dietary lysine on performance, protein deposition and respiratory chain gene expression in male broilers. A total of 252 Cobb 500 broilers were dis...
The aim of this study was to evaluate the effect of dietary lysine on performance, protein deposition and respiratory chain gene expression in male broilers. A total of 252 Cobb 500 broilers were distributed, in a completely randomized design, into four treatments with seven replicates of nine birds per experimental unit. Experimental treatments consisted of diets based on corn and soybean meal, with four levels of digestible lysine: 1.016%, 1.099%, 1.182% and 1.265%. The increase in the level of digestible lysine in the diet provided higher weight gains, feed efficiency and body protein deposition. Birds fed the lowest level of dietary lysine (1.016%) showed a lower expression of genes such as NADH dehydrogenase subunit I (ND1), cytochrome b (CYTB) and cytochrome c oxidase subunits I (COX I), II (COX II) and III (COX III), displaying the worst performance and body protein deposition. This demonstrates the relationship existing between the expression of the evaluated genes and the performance responses. In conclusion, results indicate that broilers fed diets with higher levels of digestible lysine have increased messenger RNA expression of some genes coded in the mitochondrial electron transport chain (ND1, CYTB, COX I, COX II and COX III). It may be stated that diets with proper levels of digestible lysine, within the 'ideal protein' concept, promote the expression of genes, which increases the mitochondrial energy, thereby fostering body protein deposition and the performance of broilers in the starter phase.
- Mirror, Mirror on the Wall: Children's Preferences and Self-Perceptions of Weight in a Rural Hispanic Community. [Journal Article]
- JPJ Pediatr Health Care 2016 Nov - Dec; 30(6):528-534
- CONCLUSIONS: Prepubertal children who are either overweight or obese do not accurately perceive their weight status. Rather than focusing solely on weight reduction programs, emphasis should be placed on promoting healthy lifestyles and choices.
- Intravenous Immune Globulin Stewardship Program at a Tertiary Academic Medical Center. [Journal Article]
- APAnn Pharmacother 2016 Oct 6
- CONCLUSIONS: An IVIG stewardship program, including an institution-specific prescribing guideline and a pharmacist-driven stewardship program, may ensure guideline compliance for appropriateness of indication and dose at an academic medical center.
- Clinical Practice Guidelines for Sustained Neuromuscular Blockade in the Adult Critically Ill Patient. [Journal Article]
- CCCrit Care Med 2016; 44(11):2079-2103
- To update the 2002 version of "Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient."
To update the 2002 version of "Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient."
- SSA 02-4 DISPARITIES IN HYPERTENSION MANAGEMENT OF CKD IN SOUTH ASIA. [Journal Article]
- JHJ Hypertens 2016; 34 Suppl 1 - ISH 2016 Abstract Book:e2-e3
- Chronic kidney disease (CKD) defined as reduced estimated glomerular filtration rate (eGFR) or presence of albuminuria, progresses to end stage renal disease (ESRD), needing dialysis or kidney transp...
Chronic kidney disease (CKD) defined as reduced estimated glomerular filtration rate (eGFR) or presence of albuminuria, progresses to end stage renal disease (ESRD), needing dialysis or kidney transplant to sustain life, and is associated with increased risks of premature cardiovascular disease (CVD) and mortality. CKD ranked 18 leading (and most rapidly rising cause of mortality by the Global Burden of Disease Study 2010. The social and economic consequences of CKD are far worse in low and middle income countries (LMICs) including India, Pakistan, Bangladesh, and Sri Lanka.Accoriding to successive estimates of the World Health Organization, countries in South Asia have been experiencing a progressive rise in the burden of non-communicable diseases (NCD) one facet of which is CKD. About 1 in 5 adults older aged 30 years suffer from CKD South Asia. Although national level estimates are not available, a recent meta-analysis indicated prevalence of CKD is 7.7% in South Asia based on eGFR <60 ml/min/1.73 m. However, evidence to inform CKD prevention and management programs is scarce.Hypertension and diabetes are the most important risk factors for CKD in South Asia: 1 in 3 adults has hypertension. In addition, more than 70 million people had diabetes in 2010, and this number is expected to rise to 100 million by 2030. Both high blood pressure and diabetes are common even during chilldhood. The age of onset of CKD is also younger in South Asians than noted in studies in Western populations. This is unsurprising as low birth weight and prematurity, both in part due to maternal malnutrition are common in India, and predispose to insulin resistance and CKD. Rates of progression of CKD to ESRD have been shown to be faster in people of South Asian origin than white counterparts. However, less than 10% with ESRD are able to afford RRT (annual cost US $5000) in India. The impact of lives lost due to ESRD or premature CVD are far more grave in India where majority of the population lives in conditions of poverty (Fortunately, adverse complications of CKD can be prevented by prompt detection and early institution of therapy. Healthy lifestyle (maintaining ideal body weight, physical activity, healthy diet, and smoking cessation) and pharmaceutical interventions including maintaining blood pressure control preferably with blockers of renin angiotensin system (RAS) to reduce proteinuria, and glycemic control, and reduce the risk of atherosclerotic events with lipid lowering are important for prevention of CVD and delaying progression to ESRD. However, despite the publication of evidence-based guidelines on management of CKD, serious deficiencies in provider knowledge and practices regarding management of hypertension and CKD have been identified. Thus, CKD awareness rates are abysmally poor (6 and 10%) in the general and high risk population with CKD, respectively, in South Asia. Moreover, evidence of effective community based program to prevent and manage CKD has been lacking.The Control of Blood Pressure and Risk Attenuation Trial assessed the effects of a combined public health intervention on the kidney health of hypertensive adults in Pakistan's general population. The intervention included training of community health workers on aspects of a healthy lifestyle (such as improving diet, stopping smoking, increasing physical activity, and taking prescribed blood pressure-lowering medications) and training of community general practitioners (GP) on the updated guidelines related to managing hypertension.The combined home health education (HHE) plus trained GP intervention was beneficial in preserving kidney function over 7 years among adults with hypertension in communities in Karachi. These findings highlight the importance of scaling-up simple strategies for renal risk reduction in LMICs. Efforts are needed for integrate CKD prevention and management program within the broader NCD policy framework in South Asia.
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- Preoperative High Dose of Methylprednisolone Improves Early Postoperative Pulmonary Function, in Super-Obese Patients Undergoing Open Surgery; a Prospective, Comparative Study. [Journal Article]
- JGJ Gastrointest Surg 2016 Oct 11
- CONCLUSIONS: Preoperative administration of a single high dose of methylprednisolone in super-obese patients undergoing open surgery inhibits the inflammatory signaling cascade, lessens the systemic inflammatory response, and results in fewer pulmonary complications and better patient recovery.