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integumentary system [keywords]
- Meta-analysis of the effects of sometribove zinc suspension on the production and health of lactating dairy cows. [Journal Article]
- J Am Vet Med Assoc 2014 Sep 1; 245(5):550-64.
Objective-To provide an updated evaluation of the efficacy and safety of sometribove zinc suspension (rbST-Zn), a form of recombinant bovine somatotropin, in lactating dairy cows. Design-Meta-analysis. Sample-26 studies published in peer-reviewed journals or reviewed by a regulatory agency. Procedures-To be included, a study had to involve the use of the rbST-Zn formulation available to US producers in accordance with the label instructions for treatment initiation (57 to 70 days postpartum), dose (500 mg, q 14 d), and route (SC). Results-For cows treated with rbST-Zn, mean milk, 3.5% fat-corrected milk, fat, and protein yields were increased by 4.00, 4.04, 0.144, and 0.137 kg/d (8.8, 8.89, 0.32, and 0.30 lb/d), respectively; however, the concentration of milk components did not change. Pregnancy proportion for the first 2 breeding cycles was increased by 5.4%, and pregnancy proportion for the duration of the trial was reduced by 5.5% for rbST-Zn-treated cows, compared with proportions for untreated cows. Mean body condition score (1 to 5 scale) was reduced by 0.06 points during the period of rbST-Zn use for treated cows. Administration of rbST-Zn had no effect on milk somatic cell count, the number of days to pregnancy, or inseminations per pregnancy; rates of fetal loss, twins, cystic ovaries, clinical lameness, lameness lesions, or traumatic lesions of the integumentary system; and odds of clinical mastitis or culling. Conclusions and Clinical Relevance-Results indicated that rbST-Zn administration to dairy cows effectively increases milk production with no adverse effects on cow health and well-being.
- A cross-sectional retrospective analysis of the regionalization of complex surgery. [Journal Article]
- BMC Surg 2014; 14(1):55.
The Veterans Health Administration (VHA) system has assigned a surgical complexity level to each of its medical centers by specifying requirements to perform standard, intermediate or complex surgical procedures. No study to similarly describe the patterns of relative surgical complexity among a population of United States (U.S) civilian hospitals has been completed.single year, retrospective, cross-sectional.the study used Florida Inpatient Discharge Data from short-term acute hospitals for calendar year 2009. Two hundred hospitals with 2,542,920 discharges were organized into four quartiles (Q 1, 2, 3, 4) based on the number of complex procedures per hospital. The VHA surgical complexity matrix was applied to assign relative complexity to each procedure. The Clinical Classification Software (CCS) system assigned complex procedures to clinically meaningful groups. For outcome comparisons, propensity score matching methods adjusted for the surgical procedure, age, gender, race, comorbidities, mechanical ventilator use and type of admission.in-hospital mortality and length-of-stay (LOS).Only 5.2% of all inpatient discharges involve a complex procedure. The highest volume complex procedure hospitals (Q4) have 49.8% of all discharges but 70.1% of all complex procedures. In the 133,436 discharges with a primary complex procedure, 374 separate specific procedures are identified, only about one third of which are performed in the lowest volume complex procedure (Q1) hospitals. Complex operations of the digestive, respiratory, integumentary and musculoskeletal systems are the least concentrated and proportionately more likely to occur in the lower volume hospitals. Operations of the cardiovascular system and certain technology dependent miscellaneous diagnostic and therapeutic procedures are the most concentrated in high volume hospitals. Organ transplants are only done in Q4 hospitals. There were no significant differences in in-hospital mortality rates and the longest lengths of stay were found in higher volume hospitals.Complex surgery in Florida is effectively regionalized so that small volume hospitals operating within the range of complex procedures appropriate to their capabilities provide no increased risk of post surgical mortality.
- Evolution. An epigenetic window into the past? [Journal Article, Research Support, Non-U.S. Gov't]
- Science 2014 Aug 1; 345(6196):511-2.
- An unusual case of mycosis fungoides with high proliferation index and C-MYC/8q24 translocation. [Journal Article]
- J La State Med Soc 2013 Nov-Dec; 165(6):324-8.
Mycosis fungoides is the most common entity among all cutaneous T cell lymphomas. Herein, we report for the first time a case of mycosis fungoides in a 51-year-old man with aggressive clinical course and confirmed C-MYC/8q24 translocation. Review of the literature reveals that dermal Ki-67 proliferation index not only correlates with the type and extent of skin involvement and clinical stage, but is also an independent adverse prognostic factor. Mycosis fungoides is associated with multiple genomic abnormalities, particularly in patients with tumor stage and advanced clinical stage, and gain of C-MYC/8q24 is associated with a shorter survival. Our patient showed a high dermal Ki-67 level and concomitant C-MYC/8q24 translocation, which may account for the aggressive clinical course and refractoriness to CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy.
- [Influence of different skin reactions of acupoint-application on clinical outcomes in the prevention and treatment of bronchial asthma]. [English Abstract, Journal Article]
- Zhen Ci Yan Jiu 2014 Jun; 39(3):222-7.
To observe the influence of different skin reactions of acupoint-application in summer on outcomes of prevention and treatment of bronchial asthma.All of the bronchial asthma patients were treated with acupoint-application therapy in the dog-days of summer, once every ten days, 3 times altogether. After the treatment, according to scores of the skin reactions including flush, itching, pain, vesicles, etc. induced by acupoint-application of prepared Chinese medical herb paste, 164 cases were divided into four groups: no reaction (n = 43), mild reaction (n = 42), moderate reaction (n = 39) and severe reaction (n = 40). One-year's follow-up was conducted after the treatment for assessing the asthma patients' cough-asthma score, wheezing rale score, and for recording the attack times.After the treatment, the cough-asthma scores, wheezing rale scores, and asthmatic attack times were obviously decreased in all the 4 groups compared to pre-treatment (P < 0.05, P < 0.01). Comparison among the 4 groups showed that the levels of the 3 indexes were significantly higher in the no reaction group and mild reaction group than in the moderate and severe reaction groups after the treatment (P < 0.05, P < 0.01), suggesting a better therapeutic effect in patients undergoing moderate and severe skin reactions. There were no significant differences between the no reaction and mild reaction groups, and between the moderate reaction and severe reaction groups in the levels of the 3 indexes (P > 0. 05). The total effective rates of the no reaction, mild reaction, moderate reaction and severe reaction groups were 58.14%, 88.10%, 94.87% and 97.50%, respectively. The mild, moderate and severe reaction groups were better than the no reaction group in the therapeutic effect (P < 0.01). The mild reaction group was poorer than the moderate and severe reaction groups in clinical efficacy (P < 0.05). There was no marked difference between the moderate and severe reaction groups in clinical outcomes (P > 0.05).Acupoint-application in the dog-days can effectively improve the asthma patients' symptoms, and the therapeutic effect of patients experiencing moderate and severe skin reactions was better.
- Dinosaur evolution. A Jurassic ornithischian dinosaur from Siberia with both feathers and scales. [Journal Article, Research Support, Non-U.S. Gov't]
- Science 2014 Jul 25; 345(6195):451-5.
Middle Jurassic to Early Cretaceous deposits from northeastern China have yielded varied theropod dinosaurs bearing feathers. Filamentous integumentary structures have also been described in ornithischian dinosaurs, but whether these filaments can be regarded as part of the evolutionary lineage toward feathers remains controversial. Here we describe a new basal neornithischian dinosaur from the Jurassic of Siberia with small scales around the distal hindlimb, larger imbricated scales around the tail, monofilaments around the head and the thorax, and more complex featherlike structures around the humerus, the femur, and the tibia. The discovery of these branched integumentary structures outside theropods suggests that featherlike structures coexisted with scales and were potentially widespread among the entire dinosaur clade; feathers may thus have been present in the earliest dinosaurs.
- [Elemental status of the medical personnel of the emergency medical services in the city of Khanty-Mansiysk]. [English Abstract, Journal Article]
- Gig Sanit 2014 Mar-Apr; (2):50-4.
Spectrometric analysis of hair from 110 medical workers (54--from the Emergency medical services and 56--from polyclinics) was performed with the use of atomic emission spectrometry and mass spectrometry, inductively coupled argon plasma spectrometry (AES-ISP) methods. There were revealed features of the elemental status of the medical personnel of the Emergency medical services: a deficiency of Mg, K and Li was typical for this group (presented more then in half of cases).
- Gastric trichobezoar: a diagnostic tangle. [Case Reports, Journal Article]
- Trop Gastroenterol 2013 Oct-Dec; 34(4):271-3.
- [N-stearoylethanolamine effect on the level of 11-hydroxycorticosteroids, cytokines IL-1, IL-6 and TNFalpha in rats with nonspecific inflammation caused by thermal burn of skin]. [English Abstract, Journal Article]
- Ukr Biokhim Zh 2014 May-Jun; 86(3):88-97.
The mechanisms of anti-inflammatory action of saturated N-acylethanolamine--N-stearoylethanolamine (NSE) were investigated on the rat model of nonspecific inflammation (thermal burns of the skin). The results showed that the NSE application in a form of aqueous suspension (10 mg/ml) on the damaged skin area during 12 days significantly accelerated the healing process of burned wounds. NSE also prevented the increase of 11-hydroxycorticosteroids content in the blood of rats with burns. There was also found a significant decrease of cytokines (IL-1beta, IL-6 and TNFalpha) levels under the NSE action. This way may be one of the mechanisms of NSE anti-inflammatory action.
- Granuloma annularis revealing Wegener's granulomatosis. [Letter]
- Int J Immunopathol Pharmacol 2014 Apr-Jun; 27(2):273-8.
Skin manifestations are often associated with systemic autoimmune diseases (SAD). Some SAD, such as systemic lupus erythematosus, psoriatic arthritis and scleroderma display pathognomonic dermatological features, whereas other systemic diseases such as sarcoidosis, vasculitis and rheumatoid arthritis can present with non-specific skin manifestations that range from erythema nodosum to necrotic lesions. Here we report the case of a 25-year-old man with uveitis, polyarthrirtis, pulmonary involvement, nephrotic syndrome, cutaneous granuloma and pneumonia by E. coli.