integumentary system [keywords]
- CLINICAL PROBLEM-SOLVING. Prevention as Precipitant. [Case Reports, Clinical Conference, Journal Article]
- N Engl J Med 2016 Aug 4; 375(5):471-5.
- IMAGES IN CLINICAL MEDICINE. Urticaria Multiforme. [Case Reports, Journal Article]
- N Engl J Med 2016 Aug 4; 375(5):470.
- [INTERRELATION BETWEEN THE PREOPERATIVE MORPHOLOGICAL CHARACTERISTICS OF PERIPHERAL BLOOD AND THE QUALITY OF ENGRAFTMENT OF VASCULARIZED ADIPO-FASCIO-CUTANEOUS FLAPS IN RATS]. [English Abstract, Journal Article, Research Support, Non-U.S. Gov't]
- Morfologiia 2016; 149(1):72-6.
The aim of this work was to determine the interrelation between the preoperative blood counts and the quality of vascularized adipo-fascio-cutaneous flap survival. In 10 adult male Wistar rats, a flap with the area of 18 cm2 was formed on the basis of superficial inferior epigastric artery; after a 90 min ischemic period it was replanted. 12 days after operation the quality of flap survival was assessed with computer-assisted planimetry. It was found that the combination of preoperative leukocyte, thrombocyte, neutrophil and eosinophil counts as well as reactive lymphocyte counts close to the maximal reference values increased the probability of epidermolysis.
- [CHANGES OF THE CONTENT OF DLL4 AND Jag-1 ANGIOGENESIS REGULATORS IN HUMAN DERMIS IN ONTOGENESIS]. [English Abstract, Journal Article, Research Support, Non-U.S. Gov't]
- Morfologiia 2016; 149(1):48-52.
The goal of this study was to examine the contents of D114 and Jag-1 angiogenesis regulators in human dermis at different age periods. D114 and Jag-1 were demonstrated by indirect immunohistochemistry in skin sections of fetuses of 20-40 gestational weeks and in persons aged from birth to 85 years. D114 was studied in 150 skin samples of 72 females and 78 males, while Jag-1 was examined in 120 samples of 58 females and 62 males. It is found that the immunoreactivity was mainly expressed by the endothelial cells. Vessels, which gave a positive reaction to D114 and Jag-1, were found throughout the entire thickness of the dermis, both in fetuses, and people of all age groups. Expression of D114 in the vessels of dermal microvasculature was shown to increase from 20 weeks of gestation to 20 years. With the further age increase, the intensity of the reaction of blood vessels for D114 was decreased. Expression of Jag-1 in dermal microvessels was enhanced from 20 weeks of gestation to 85 years. The results are discussed in connection with the role of D114 and Jag-1 in angiogenesis in human dermis during ontogeny.
- IMAGES IN CLINICAL MEDICINE. Thyroid Ophthalmopathy, Dermopathy, and Acropachy. [Case Reports, Journal Article]
- N Engl J Med 2016 Jul 21; 375(3):261.
- Unusual way of feeding by the deutonymph of Neottialges evansi (Actinotrichida, Astigmata, Hypoderatidae), a subcutaneous parasite of cormorants, revealed by fine structural analyses. [JOURNAL ARTICLE]
- J Morphol 2016 Jul 27.
The parasitic deutonymphs of hypoderatid mites live within the subcutaneous layer of their avian hosts, where they become greatly engorged despite not having functional mouthparts. The method by which they take up nutrients has been mysterious up to now. Here, we report on the morphology of hypoderatid deutonymphs using scanning and transmission electron microscopy and describe structures that may resolve the mystery. The deutonymph of Neottialges evansi (Hypoderatidae) from the cormorant Phalacrocorax carbo is a simply organized stage lacking both mouthparts and a functional foregut. The structure of midgut and hindgut indicate that they are not capable of processing food. The midgut consists of highly branching flat cells and rarely shows a lumen. Almost the entire space between integument, gut remnants and other organs (synganglion, developing gonads) is filled by huge cells containing protein and glycogen granules and numerous lipid inclusions. The anal opening is minute. The structure of the cuticle and epidermis suggests that nutrients are not absorbed through the general integument. Thus the two main existing hypotheses about feeding modes in hypoderatid deutonymphs, anal vs. integumentary food absorbtion, are not supported. We suggest instead that two pairs of genital papillae showing peculiar microanatomical features are actively involved in movement of liquid materials between host and mite and most probably are the nutrient-intake organs. J. Morphol., 2016. © 2016 Wiley Periodicals, Inc.
- Physical Training and Activity in People With Diabetic Peripheral Neuropathy: A Paradigm Shift. [JOURNAL ARTICLE]
- Phys Ther 2016 Jul 21.
Diabetic peripheral neuropathy (DPN) occurs in more than 50% of people with diabetes and is an important risk factor for skin breakdown, amputation, and reduced physical mobility (i.e., walking and stair climbing). Although it is well-established that exercise has many beneficial effects for people with diabetes, few studies have examined whether exercise provides comparable benefits to people with DPN. Until recently, DPN was considered a contra-indication for walking or any weight-bearing exercise due to concerns for injuring the participant's insensitive feet. These guidelines were recently adjusted, however, after research demonstrated that weight-bearing activities do not increase the risk of foot ulcers in people with DPN without severe foot deformity. In fact, emerging research has found positive adaptations to overload stress in these patients, including evidence for peripheral neuroplasticity in animal models and early clinical trials. This Perspective will review this evidence for peripheral neuroplasticity in animal models and early clinical trials, and adaptation of the integumentary system and the musculoskeletal system in response to overload stress. We propose these positive adaptations promote improved function in people with DPN and foster the paradigm shift of including weight-bearing exercise for people with DPN. This Perspective also will provide specific assessment and treatment recommendations for this important, high-risk group.
- Plastic Surgery after Massive Weight Loss. [Journal Article, Review]
- Mo Med 2016 May-Jun; 113(3):202-6.
Bariatric surgery rates have increased in the United States concurrent with the rise in obesity. As a result of the massive weight loss from these surgeries, patients are left with a different set of functional and cosmetic issues related to excess skin. Plastic surgery has evolved to treat these unique issues faced by this patient population and has demonstrated beneficial effects. This article will provide an overview of the options available to massive weight loss patients to treat specifically affected area of the body.
- [CLINICAL CHARACTERISTIC OF POSTOPERATIVE STATE OF CICATRICIALLY-CHANGED CUTANEOUS TISSUES]. [English Abstract, Journal Article]
- Klin Khir 2016 Apr; (4):61-3.
Abstract Comparison of postoperative kinds of cicatrix was conducted in 60 patients, depending on the suture material applied. Best conditions for the operative wound healing, achievement of more esthetic normotrophic cicatrix were guaranteed by application of a cutaneous adhesive.
- Cationic Polymeric Nanocapsules as a Strategy to Target Dexamethasone to Viable Epidermis: Skin Penetration and Permeation Studies. [Journal Article, Research Support, Non-U.S. Gov't]
- J Nanosci Nanotechnol 2016 Feb; 16(2):1331-8.
The present work aimed to evaluate the behavior of dexamethasone-loaded cationic polymericnanocapsules in hydrogels, regarding their in vitro drug release and skin drug retention and per- meation. Cationic polymeric nanocapsules prepared with Eudragit RS 100 as the polymeric wall had mean particle size of 139 +/- 3.6 nm, positive zeta potential (+11.38 +/- 1.7 mV), and high encapsulation efficiency (81 +/- 2%). After preparation, they were formulated as hydrogels, which showed non-Newtonian, plastic behavior, and acidic pH. Photon correlation spectroscopy analysis of these hydrogels demonstrated the presence of particles with mean particle size close to that of the original colloidal suspensions. The presence of dexamethasone-loaded nanocapsules in hydrogels promoted controlled drug release and an increase in the amount of drug delivered into viable epidermis, the main target tissue to topical glucocorticoid action. Moreover, the formulation did not increase the risk of drug penetration to dermis and permeation to the receptor compartment.