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integumentary system [keywords]
- Response to Comment on "A Jurassic ornithischian dinosaur from Siberia with both feathers and scales". [Comment, Journal Article]
- Science 2014 Oct 24; 346(6208):434.
Lingham-Soliar questions our interpretation of integumentary structures in the Middle-Late Jurassic ornithischian dinosaur Kulindadromeus as feather-like appendages and alternatively proposes that the compound structures observed around the humerus and femur of Kulindadromeus are support fibers associated with badly degraded scales. We consider this hypothesis highly unlikely because of the taphonomy and morphology of the preserved structures.
- Comment on "A Jurassic ornithischian dinosaur from Siberia with both feathers and scales". [Comment, Journal Article]
- Science 2014 Oct 24; 346(6208):434.
Godefroit et al. (Reports, 25 July 2014, p. 451) reported scales and feathers, including "basal plates," in an ornithischian dinosaur. Their arguments against the filaments being collagen fibers are not supported because of a fundamental misinterpretation of such structures and underestimation of their size. The parsimonious explanation is that the filaments are support fibers in association with badly degraded scales and that they do not represent early feather stages.
- Efinaconazole 10% nail solution: a post-FDA approval update. [Journal Article]
- Skinmed 2014 Jul-Aug; 12(4):235-7.
- Tinea lucidum or dermatophytosis of the stratum lucidum: is the epidermal location of dermatophyte infection evolving? [Journal Article]
- Skinmed 2014 Jul-Aug; 12(4):226-30.
Dermatophyte infections are traditionally localized to the stratum corneum. The advent of immunosuppressants and topical steroid/antifungal preparations, however, has created a new phenomenon: dermatophytosis in the stratum lucidum. This atypical presentation manifests in 3 clinical scenarios: oral immunosuppression and/or medical comorbidities, lesions/body sites with lichenification, and sites on/near acral skin. In each setting, superficial potassium hydroxide (KOH) preparations have proved ineffective in diagnosis, despite high indices of suspicion for dermatophytosis. It is only under histologic examination that florid hyphal elements are identified. The authors propose a modified KOH technique requiring a sample of deeper, pathological scale-containing fungal elements to be used in scenarios where tinea lucidum or dermatophyte infection of the stratum lucidum may be present.
- Asymmetric gait nail unit syndrome: the most common worldwide toenail abnormality and onychomycosis. [Journal Article]
- Skinmed 2014 Jul-Aug; 12(4):217-23.
Asymmetric gait nail unit syndrome (AGNUS) is the result of asymmetric shoe pressure on the toes and foot caused by ubiquitous uneven flat feet that affect the gait. The pressure produces clinical changes in the toenails, which are identical to all clinical types of dermatophyte and opportunistic onychomycosis, yet they are dermatophytes-free. AGNUS produces additional signs that make it easy to identify. Its coexistence with fungal disease has resulted in reports describing new clinical types of onychomycosis, identifying signs of drug resistance, assessing severity index, and defining complete clinical cure when taking a systemic or topical antifungal, as well as "retronychia." These signs are typically seen in the toenails of patients with AGNUS. AGNUS has a mechanical etiology and can coexist with dermatophytosis, which is a hereditary disease. AGNUS can coexist with any other disease affecting the toenails and results in greater clinical severity than each condition individually. AGNUS is and has been the most common worldwide toenail abnormality in shoe-wearing societies.
- Surgical hair restoration and the advent of a robotic-assisted extraction device. [Journal Article]
- Skinmed 2014 Jul-Aug; 12(4):213-6.
The number of surgical hair restorations performed worldwide is ever-increasing. Today's gold standard in surgical hair restoration is follicular unit transplantation (FUT). FUT refers to the transplantation of individual follicular units (FUs) from the donor region to the recipient region. Strip extraction and manual FU extraction (FUE) are the most common methods for FU production. While strip extraction and manual FUE both hold individual merits, they are also associated with a number of limitations. The introduction of a robotic surgical assistive device may circumvent many of the limitations associated with traditional strip and manual FUE methods. As with all new technologies, however, the robotic device will require further independently funded, peer-reviewed, clinical testing to establish its efficacy relative to existing hair restoration methods in clinical practice.
- An automated system for detecting and measuring nailfold capillaries. [Journal Article, Research Support, Non-U.S. Gov't]
- Med Image Comput Comput Assist Interv 2014; 17(Pt 1):658-65.
Nailfold capillaroscopy is an established qualitative technique in the assessment of patients displaying Raynaud's phenomenon. We describe a fully automated system for extracting quantitative biomarkers from capillaroscopy images, using a layered machine learning approach. On an unseen set of 455 images, the system detects and locates individual capillaries as well as human experts, and makes measurements of vessel morphology that reveal statistically significant differences between patients with (relatively benign) primary Raynaud's phenomenon, and those with potentially life-threatening systemic sclerosis.
- [The epidemiology of demodex mites at the college students living in dormitories in the city of Ordu]. [English Abstract, Journal Article]
- Turkiye Parazitol Derg 2014; 38(3):166-71.
Demodex folliculorum and Demodex brevis can cause different skin and eye symptoms. There are indications showing that the prevalence of these parasites is higher in public places. In this direction, the study was aimed to determine the prevalence of demodex in university students, inhabiting in dormitories.The study consisted of 300 men and women, college students who were staying in the dormitories in the city of Ordu. Random sampling method was used in the sample selection. Each participating student had to sign a patient's consent form, before samples were taken using standard superficial skin biopsies from the faces of the patients. The samples were embedded in Entellan mounting solution and examined under the light microscope.Samples were taken from 300 college students (170 males and 130 females) aged between 18-30 years, and in 110 (37%) of them, demodex mites were found. No significant differences were found between gender, age, type of skin or skin care, and Demodex incidence.Demodex mites are very prevalent in college students studying in Ordu.
- Preparation and in vitro evaluation of a pluronic lecithin organogel containing ricinoleic acid for transdermal delivery. [Comparative Study, Journal Article, Research Support, Non-U.S. Gov't]
- Int J Pharm Compd 2014 May-Jun; 18(3):256-61.
The present study deals with the preparation and in vitro evaluation of a Pluronic lecithin organogel gel containing ricinoleic acid for transdermal delivery. Blank Pluronic lecithin organogel gels were prepared using ricinoleic acid as the oil phase and characterized for pH, viscosity, gelation temperature, and microscopic structure. The optimized Pluronic lecithin organogel gel formulation was further evaluated using ketoprofen (10%) and dexamethasone (0.5%) as model drugs. The stability and in vitro permeability of ketoprofen and dexamethasone was evaluated and compared with the corresponding control formulation (Pluronic lecithin organogel gel made with isopropyl palmitate as the oil phase). The pH and viscosity of blank Pluronic lecithin organogel gel prepared with ricinoleic acid was comparable with the isopropyl palmitate Pluronic lecithin organogel gel. The thixotropic property of ricinoleic acid Pluronic lecithin organogel gel was found to be better than the control. Drug-loaded Pluronic lecithin organogel gels behaved in a similar manner and all formulations were found to be stable at 25 degrees C, 35 degrees C, and 40 degrees C for up to 35 days. The penetration profile of dexamethasone was similar from both the Pluronic lecithin organogel gels, while the permeability for ketoprofen from Pluronic lecithin organogel gel containing ricinoleic acid was found to be three times higher as compared to the control formulation.
- Prolidase deficiency: dento-facial aspects in a paediatric patient. [Case Reports, Journal Article]
- Eur Arch Paediatr Dent 2014 Jul; 15(2 Suppl):224-8.
Prolidase Deficiency (PD) is a rare hereditary disease consisting in developmental delay, mental retardation, facial dysmorphism, splenomegaly, recurrent pulmonary infections and skin lesions.The present study reports a case of PD treated in the Paediatric Section of the Department of Dentistry and Surgery at the University of Bari. A special diagnostic and clinical approach to the patient was useful to improve his quality of life and identify some new aspects of this systemic disease. In particular, clinical features never described before are reported: low hair line, decreased osteotendinous reflexes, long upper lip, microrhinia, dentoskeletal Class III, dental age (Proffit) older than chronological age, fusion of 2nd and 3rd cervical vertebrae, incomplete atlanto-occipital fusion.