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integumentary system [keywords]
- Images in clinical medicine. Aquagenic keratoderma. [Case Reports, Journal Article]
- N Engl J Med 2014 Sep 4; 371(10):952.
- Nail gun penetrating cardiac injury in a young child. [Journal Article]
- Lancet 2014 Aug 30; 384(9945):828.
- Meta-analysis of the effects of sometribove zinc suspension on the production and health of lactating dairy cows. [Journal Article]
- J Am Vet Med Assoc 2014 Sep 1; 245(5):550-64.
Objective-To provide an updated evaluation of the efficacy and safety of sometribove zinc suspension (rbST-Zn), a form of recombinant bovine somatotropin, in lactating dairy cows. Design-Meta-analysis. Sample-26 studies published in peer-reviewed journals or reviewed by a regulatory agency. Procedures-To be included, a study had to involve the use of the rbST-Zn formulation available to US producers in accordance with the label instructions for treatment initiation (57 to 70 days postpartum), dose (500 mg, q 14 d), and route (SC). Results-For cows treated with rbST-Zn, mean milk, 3.5% fat-corrected milk, fat, and protein yields were increased by 4.00, 4.04, 0.144, and 0.137 kg/d (8.8, 8.89, 0.32, and 0.30 lb/d), respectively; however, the concentration of milk components did not change. Pregnancy proportion for the first 2 breeding cycles was increased by 5.4%, and pregnancy proportion for the duration of the trial was reduced by 5.5% for rbST-Zn-treated cows, compared with proportions for untreated cows. Mean body condition score (1 to 5 scale) was reduced by 0.06 points during the period of rbST-Zn use for treated cows. Administration of rbST-Zn had no effect on milk somatic cell count, the number of days to pregnancy, or inseminations per pregnancy; rates of fetal loss, twins, cystic ovaries, clinical lameness, lameness lesions, or traumatic lesions of the integumentary system; and odds of clinical mastitis or culling. Conclusions and Clinical Relevance-Results indicated that rbST-Zn administration to dairy cows effectively increases milk production with no adverse effects on cow health and well-being.
- A cross-sectional retrospective analysis of the regionalization of complex surgery. [Journal Article]
- BMC Surg 2014; 14(1):55.
The Veterans Health Administration (VHA) system has assigned a surgical complexity level to each of its medical centers by specifying requirements to perform standard, intermediate or complex surgical procedures. No study to similarly describe the patterns of relative surgical complexity among a population of United States (U.S) civilian hospitals has been completed.single year, retrospective, cross-sectional.the study used Florida Inpatient Discharge Data from short-term acute hospitals for calendar year 2009. Two hundred hospitals with 2,542,920 discharges were organized into four quartiles (Q 1, 2, 3, 4) based on the number of complex procedures per hospital. The VHA surgical complexity matrix was applied to assign relative complexity to each procedure. The Clinical Classification Software (CCS) system assigned complex procedures to clinically meaningful groups. For outcome comparisons, propensity score matching methods adjusted for the surgical procedure, age, gender, race, comorbidities, mechanical ventilator use and type of admission.in-hospital mortality and length-of-stay (LOS).Only 5.2% of all inpatient discharges involve a complex procedure. The highest volume complex procedure hospitals (Q4) have 49.8% of all discharges but 70.1% of all complex procedures. In the 133,436 discharges with a primary complex procedure, 374 separate specific procedures are identified, only about one third of which are performed in the lowest volume complex procedure (Q1) hospitals. Complex operations of the digestive, respiratory, integumentary and musculoskeletal systems are the least concentrated and proportionately more likely to occur in the lower volume hospitals. Operations of the cardiovascular system and certain technology dependent miscellaneous diagnostic and therapeutic procedures are the most concentrated in high volume hospitals. Organ transplants are only done in Q4 hospitals. There were no significant differences in in-hospital mortality rates and the longest lengths of stay were found in higher volume hospitals.Complex surgery in Florida is effectively regionalized so that small volume hospitals operating within the range of complex procedures appropriate to their capabilities provide no increased risk of post surgical mortality.
- Feeding by Amblyomma maculatum (Acari: Ixodidae) enhances Rickettsia parkeri (Rickettsiales: Rickettsiaceae) infection in the skin. [Journal Article, Research Support, N.I.H., Extramural]
- J Med Entomol 2014 Jul; 51(4):855-63.
Rickettsia parkeri Luckman (Rickettsiales: Rickettsiaceae), a member of the spotted fever group of Rickettsia, is the tick-borne causative agent of a newly recognized, eschar-associated rickettsiosis. Because of its relatively recent designation as a pathogen, few studies have examined the pathogenesis of transmission of R. parkeri to the vertebrate host. To further elucidate the role of tick feeding in rickettsial infection of vertebrates, nymphal Amblyomma maculatum Koch (Acari: Ixodidae) were fed on C3H/HeJ mice intradermally inoculated with R. parkeri (Portsmouth strain). The ticks were allowed to feed to repletion, at which time samples were taken for histopathology, immunohistochemistry (IHC), quantitative polymerase chain reaction (qPCR) for rickettsial quantification, and reverse transcriptase polymerase chain reaction (RT-PCR) for expression of Itgax, Mcp1, and Il1beta. The group of mice that received intradermal inoculation of R. parkeri with tick feeding displayed significant increases in rickettsial load and IHC staining, but not in cytokine expression, when compared with the group of mice that received intradermal inoculation of R. parkeri without tick feeding. Tick feeding alone was associated with histopathologic changes in the skin, but these changes, and particularly vascular pathology, were more pronounced in the skin of mice inoculated previously with R. parkeri and followed by tick feeding. The marked differences in IHC staining and qPCR for the R. parkeri with tick feeding group strongly suggest an important role for tick feeding in the early establishment of rickettsial infection in the skin.
- Chemical constituents of Dendrobium venustum and their antimalarial and anti-herpetic properties. [Journal Article, Research Support, Non-U.S. Gov't]
- Nat Prod Commun 2014 Jun; 9(6):825-7.
A MeOH extract from the whole plant Dendrobium venustum exhibited significant antimalarial and anti-herpetic activities. Bioassay-guided isolation of the plant extract resulted in the isolation of seven known phenolic compounds. Densiflorol B (3) and phoyunnanin E (6) showed the strongest antimalarial activity and a high selectivity index, whereas gigantol (2), batatasin III (5) and phoyunnanin C (7) exhibited moderate activity. Compounds 2 and 5 also showed weak activity against the Herpes simplex virus. This study is the first report on the chemical and biological activities of D. venustum.
- [Lentigo maligna: a diagnostic and therapeutic challenge]. [Editorial, English Abstract]
- Harefuah 2014 May; 153(5):259-60, 306, 305.
Lentigo maligna is an early type of melanoma which appears in sun damaged skin. The clinical diagnosis as well as the pathological diagnosis are a challenge to the clinician and the pathologist since atypical proliferation of melanocytes is a common finding in chronically sun exposed skin. The use of a dermatoscope and in vivo reflectance confocal microscopy as diagnostics aids can make the clinical diagnosis more accurate. Mohs micrographic surgery has become the standard of care, if available, for lentigo maligna.
- [Clinical utility of reflectance confocal microscopy for the non-invasive diagnosis of lentigo maligna melanoma]. [English Abstract, Journal Article]
- Harefuah 2014 May; 153(5):248-52, 306.
Lentigo maligna melanoma (LMM), a melanoma subtype that arises on sun-damaged facial skin, is difficult to diagnose clinically. Patients and physicians are reluctant to perform unnecessary facial biopsies. Reflectance confocal microscopy (RCM) is a novel technique for non-invasive skin imaging at cellular-level resolution. RCM increases the accuracy of melanoma diagnosis.To describe the diagnostic utility of RCM in cases of clinically and dermatoscopically equivocal pigmented skin lesions suspicious for LMM.This is a retrospective case series derived from the population of patients undergoing periodic skin cancer screening at a tertiary hospital clinic that specializes in skin cancer diagnosis. All patients consented to RCM imaging as an ancillary test prior to the decision on performing a biopsy in the facial lesion.We report on four patients who presented clinically and dermatoscopically equivocal pigmented skin lesions in the head and neck region, with differential diagnosis of LMM. Furthermore, in two patients, a prior incisional biopsy indicated a benign diagnosis upon histopathological analysis. In all cases, RCM examination showed specific criteria for LMM. The RCM diagnosis of LMM allowed direct referral for excisional surgery in three patients. In another patient, RCM findings guided incisional biopsy-site selection to a focus that revealed histopathology clear-cut criteria for LMM.RCM is a very useful adjunct to the non-invasive diagnosis of LMM.
- Evolution. An epigenetic window into the past? [Journal Article, Research Support, Non-U.S. Gov't]
- Science 2014 Aug 1; 345(6196):511-2.
- The regulatory mechanism of microRNAs in skin and hair follicle development. [Journal Article, Research Support, Non-U.S. Gov't, Review]
- Yi Chuan 2014 Jul; 36(7):655-60.
MicroRNAs (miRNAs) are an emerging class of regulators that control post-transcriptional processes, and could be potential targets for drug in pathology and potential sites of phenotypic regulation. Although some functions of miRNAs have been known, the regulatory mechanism of miRNAs in skin and hair follicle development remains unclear. High throughput sequencing provides more accurate and rapid method for identification of miRNAs. It has been found that some miRNAs affect the cell differentiation and proliferation of skin and hair follicles, and their target genes play important roles in the periodic growth of hair follicles. In this review, we summarize the recent achievements of the regulatory mechanism of miRNAs in the skin follicles and provide useful clues for further study on miRNA regulation in hair follicle growth of cashmere goat.