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- [Postoperative analgesia with nefopam and non-steroidal anti-inflammatory drugs in patients after surgery for tumors of head and neck]. [English Abstract, Journal Article]
- Anesteziol Reanimatol 2014 Jan-Feb; (1):40-3.
83 adult patients included in the study were divided into two groups. Patients of the group-1 (n-49) had medium level of pain after cancer head and neck surgery. Patients of the group-2 (n-34) had severe pain. Three first postoperative days their post-operative multimodal analgesia started with tenoxycam 20 mg i.m. after induction of anesthesia, then every 24 hour (58 patients). 25 patients got ketoprofen 100 mg i.m. every 8-12 hours instead of tenoxycam. All patients had nefopam 30 mg i.m. 30 min prior the end of surgery procedure, and every 8 hours afterwards. 7 patients of the group-1 had more than 4 pain scores (day 1), 4 patients--at the day 2. They received tramadol or paracetamol additionally. 7 patients (group-2) also had up to 5 pain scores on the day 1, 5 patients had 4 pain scores on the day 2, and 3 patients 4 pain scores on the day 3. All that patients received additional analgesia with tramadol or trimeperidine once a day. 8.4% of patients suffered from adverse reactions (tachycardia, PONV and sweating).This method of multimodal postoperative analgesia is very simple and fairly efficient.
- [Effect of early multimodal rehabilitation on postoperative recovery after abdominal hysterectomy]. [English Abstract, Journal Article]
- Anesteziol Reanimatol 2013 Nov-Dec; (6):37-41.
Purpose of the study was to evaluate the impact of the use of enhanced recovery after surgery for the postoperative period, and the inflammatory response after hysterectomy.Methods Prospectively, 50 patients ASA 1-2 aged 42-72 years were randomized into two groups: the ERAS group (n = 25) and the control group (CG) with traditional perioperative management (n = 25). combined spinal and epidural anesthesia technique was used in all patients. Patient-controlled epidural analgesia in the ERAS group and multimodal analgesia with combination of paracetamol, tramadol and ketoprofen in the control group were used postoperatively. We measured plasma concentrations of interleukin-6 (IL-6), interleuki-nIL-1beta (IL-1beta) and C-reactive protein (CRP) preoperatively and at 24 hours and 7 days after surgery. Data were analyzed by Mann-Whitney U test and presented as median (25th- 75th percentiles).There was no statistically significant differences in the IL-6 and IL-1beta concentrations throughout the study. At 6 and 24 hours the pain severity of according to VAS was higher in the control group at rest and on coughing during all study stages. We found no correlation between the level of pain and plasma concentrations of IL-1beta and IL-6. The plasma concentration of CRP in the control group was higher at 24 hours and at 7 days after surgery: (P < 0.01). Level of CRP in the control group tended to increase during the observation period.In our study, the serum concentration of IL-6 and IL-1beta did not depend on the method of postoperative pain management. Using the ERAS protocol reduced postoperative plasma concentration of CRP. The increased level of CRP in the control group may be related with autoimmune reaction in wound due to delayed mobilization of patients.
- Pharmacokinetics of the individual enantiomer S-(+)-ketoprofen after intravenous and oral administration in dogs at two dose levels. [JOURNAL ARTICLE]
- Res Vet Sci 2014 Apr 2.
The pharmacokinetic of the individual S-(+)-enantiomer of ketoprofen, S-(+)-ketoprofen, after intravenous (IV) and oral (PO) administration was determined in six dogs at 1 and 3 mg/kg. Plasma concentrations were determined by high performance liquid chromatography with ultraviolet detection. The concentration-time curves were analyzed by non-compartmental methods. Steady-state volume of distribution (Vss) and clearance (Cl) of S-(+)-ketoprofen after IV administration were 0.22 ± 0.07 and 0.19 ± 0.03 L/kg, and 0.10 ± 0.02 and 0.09 ± 0.01 L/h/kg, at 1 and 3 mg/kg, respectively. Following PO administration, S-(+)-ketoprofen achieved maximum plasma concentrations of 4.91 ± 0.76 and 12.47 ± 0.62 μg/ml, at two dose levels, respectively. The absolute bioavailability after PO route was 88.66 ± 12.95% and 85.36 ± 13.90%, respectively.
- Carbon coated titanium dioxide nanotubes: Synthesis, characterization and potential application as sorbents in dispersive micro solid phase extraction. [JOURNAL ARTICLE]
- J Chromatogr A 2014 Apr 3.
In this article, carbon coated titanium dioxide nanotubes (c-TNTs) have been synthesized. The synthesis of the bare TNTs (b-TNTs) using anatase as precursor and their coating with a caramel layer have been performed by simple and cheap hydrothermal processes. The final conversion of the caramel layer in a carbon coating has been accomplished by a thermal treatment (600°C) in an inert (Ar) atmosphere. The c-TNTs have been characterized by different techniques including transmission microscopy, infrared spectroscopy, X-ray powder diffraction, thermogravimetry and Brunauer, Emmett and Teller (BET) adsorption isotherms. The extraction performance of the c-TNTs under a microextraction format has been evaluated and compared with that provided by b-TNTs and multiwalled carbon nanotubes (MWCNTs) using naproxen and ketoprofen as model analytes. c-TNTs provided better results than the other nanoparticles, especially at low acidic pH values. In addition, c-TNTs presented a better dispersibility than MWCNTs, which is very interesting for their use in dispersive micro-solid phase extraction. Finally, a microextraction format, adapted to low sample volumes, has been proposed and applied for the determination of naproxen and ketoprofen in saliva and urine samples by liquid chromatography with UV detection. The results indicate that this approach is promising for the analysis of biological samples. In fact, the recoveries were in the range between 96% and 119% while the precision, expressed as relative standard deviation, was better than 8.5% and 26.3% for urine and saliva, respectively. The detection limits were in the range 34.1-40.8μg/L for saliva samples and 81.1-110μg/L for urine samples.
- [Treatment of back pain (ketoprofen and other methods)]. [Journal Article]
- Zh Nevrol Psikhiatr Im S S Korsakova 2014; 114(2):81-6.
- Behaviour of nonsteroidal anti-inflammatory drugs and eight of their metabolites during wastewater treatment studied by hollow fibre liquid phase microextraction and liquid chromatography mass spectrometry. [JOURNAL ARTICLE]
- Sci Total Environ 2014 Apr 9.:300-308.
In this work hollow fibre liquid phase microextraction combined with liquid chromatography mass spectrometry was applied for the determination of the nonsteroidal anti-inflammatory drugs (NSAIDs) ketoprofen, naproxen, diclofenac and ibuprofen as well as eight of their known human metabolites in wastewater samples. Extraction time and addition of tri-n-octylphosphine oxide (TOPO) to the liquid membrane were evaluated resulting in a method with an optimal extraction time of 5h and 5% (w/V) TOPO addition to the membrane liquid (di-n-hexyl ether). With the optimized method, enrichment factors ranged between 778 and 4830. The method was applied for analysis of samples collected from Källby wastewater treatment plant in the city of Lund, Sweden. Samples were collected from the influent, water entering as well as exiting the conventional activated sludge treatment and the effluent to study the behaviour of these compounds during the treatment process. All twelve substances were found in the influent and for all four drugs, higher concentrations were detected of the metabolites than the parent compounds. Highest concentrations were detected of o-desmethylnaproxen, 2-hydroxyibuprofen and carboxyibuprofen (average influent concentrations of 45, 35 and 63μg/L respectively). The study showed only partial removal during the primary treatment whereas both parent compounds and metabolites were efficiently removed during the activated sludge process. In the effluent all analytes were detected in concentrations below 1μg/L thus showing that either the investigated metabolites do not belong to the NSAID transformation products formed during the activated sludge treatment or they are also quickly further transformed within the treatment.
- Serious photocontact dermatitis induced by topical ketoprofen depends on the formulation. [JOURNAL ARTICLE]
- Eur J Dermatol 2014 Apr 11.
Background: Topical administration of ketoprofen to treat local subcutaneous pain significantly reduces gastrointestinal and cardiovascular adverse effects associated with oral delivery. However, this benefit must be weighed against the risk of photosensitisation/phototoxicity. Objective: To substantiate the safety and efficacy of topical ketoprofen delivery from a patch. Methods: Experiments were performed, and published information analysed, (a) to confirm the superior skin permeability and pharmacological activity of ketoprofen, and (b) to demonstrate the lower incidence of ketoprofen photosensitisation/phototoxicity when delivered from a topical patch. Results: Ketoprofen's photodegradation products were more photoallergic than the drug itself. The period post-ketoprofen treatment that skin should be protected from UV radiation (while the drug is cleared from the application site) was estimated. Conclusions: Photosensitisation to ketoprofen can be mitigated by a patch formulation, which protects the drug from direct UV exposure during skin application, and reduces the formation of even more photoallergic photodegradation products.
- Comparison of different sorbent materials for solid-phase extraction of selected drugs in human urine analyzed by UHPLC-UV. [JOURNAL ARTICLE]
- J Chromatogr B Analyt Technol Biomed Life Sci 2014 Mar 15.:22-28.
A procedure based on solid-phase extraction (SPE) followed by ultra-high-performance liquid chromatography (UHPLC) with UV detection has been developed for the analysis of multiple drugs in human urine. The compounds evaluated were aliskiren, prasugrel, rivaroxaban, prednisolone, propranolol, ketoprofen, nifedipine, naproxen, terbinafine, ibuprofen, diclofenac, sildenafil and acenocoumarol. Seventeen different solid phase extraction (SPE) cartridges were tested to evaluate their applicability for the isolation of drugs from human urine. Comparison were recovery of different drugs and reproducibility. The samples were analyzed by UHPLC using a Poroshell 120 EC-C18 column and acetonitrile -0.05% TFA in water as the mobile phase under gradient elution conditions. SPE combined with UHPLC-UV allowed the determination of drugs over a linear range of 0.01-30.0μg/mL, with limits of detection at 0.003-0.217μg/mL and precision of 0.8-7.1%. Phenyl (C6H5) sorbent was found to provide the most effective clean-up, removing the greatest amount of interfering substance and simultaneously ensuring analyte recoveries higher than 85.5% with relative standard deviations (RSD) <10%. The method was applied with good accuracy and precision in the determination of drugs in human urine obtained from patients treated with selected drugs.
- Trace analysis of benzophenone-derived compounds in surface waters and sediments using solid-phase extraction and microwave-assisted extraction followed by gas chromatography-mass spectrometry. [Journal Article]
- Anal Bioanal Chem 2014 May; 406(13):3179-90.
This study describes a procedure for determining eight benzophenone-derived compounds in surface waters and sediments. These include the pharmaceutical ketoprofen, its phototransformation products 3-ethylbenzophenone and 3-acetylbenzophenone, and five benzophenone-type ultraviolet (UV) filters. The proposed analytical method involves the pre-concentration of water samples by solid-phase extraction (SPE) and microwave-assisted extraction (MAE) of sediment samples followed by derivatization and analysis by gas chromatography-mass spectrometry. Different parameters were investigated to achieve optimal method performance. Recoveries of 91 to 96 % from water samples were obtained using HLB Oasis SPE cartridges, whereas MAE of sediments (30 min at 150 °C) gave recoveries of 80 to 99 %. Limits of detection were between 0.1 and 1.9 ng L(-1) for water samples and from 0.1 to 1.4 ng g(-1) for sediment samples. The developed method was applied to environmental samples and revealed the presence of UV filters in the majority of the surface waters with up to 690 ng L(-1) of 2-hydroxy-4-methoxybenzophenone. By contrast, ketoprofen (≤2,900 ng L(-1)) and its degradation products (≤320 ng L(-1)) were found in only two rivers, both receiving wastewater treatment plant effluents. Sediment analysis revealed benzophenone to be present in concentrations up to 650 ng g(-1), whereas concentrations of other compounds were considerably lower (≤32 ng L(-1)). For the first time, quantifiable amounts of two ketoprofen transformation products in the aqueous environment are reported.
- Effects of ketoprofen for prevention of postoperative cognitive dysfunction in aged rats. [JOURNAL ARTICLE]
- J Anesth 2014 Mar 28.
Postoperative cognitive dysfunction is a common geriatric complication that may be associated with increased mortality. Here, we investigated the effects of postoperative analgesia with ketoprofen on cognitive functions in aged animals and compared its effectiveness to morphine. Rats were randomly allocated to one of four groups: isoflurane anesthesia without surgery (group C), isoflurane anesthesia with laparotomy (group IL), and isoflurane anesthesia with laparotomy plus postoperative analgesia with ketoprofen or morphine. There was no difference in postoperative locomotor activity among groups. In group IL, postoperative pain levels assessed by the Rat Grimace Scale significantly increased until 8 h after surgery, which was similarly inhibited by both ketoprofen and morphine. Cognitive function was assessed using radial arm maze testing for 12 consecutive days from postoperative day 3. Results showed that the number of memory errors in group IL were significantly higher than those in goup C. However, both ketoprofen and morphine could attenuate the increase in memory errors following surgery to a similar degree. Conversely, ketoprofen showed no effect on cognitive function in the nonsurgical rats that did not experience pain. Our findings suggest that postoperative analgesia with ketoprofen can prevent the development of surgery-associated memory deficits via its pain-relieving effects.