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- Making sense of optogenetics. [JOURNAL ARTICLE]
- Int J Neuropsychopharmacol 2015 Jul 25.
- Urinary incontinence a first presentation of central pontine myelinolysis: a case report. [JOURNAL ARTICLE]
- Age Ageing 2015 Jul 23.
- Intrasensory Redundancy Facilitates Infant Detection of Tempo: Extending Predictions of the Intersensory Redundancy Hypothesis. [JOURNAL ARTICLE]
- Infancy 2015 Jul-Aug; 20(4):377-404.
- Comparison of Arthrodesis with Total Contact Casting for Midfoot Ulcerations Associated with Charcot Neuroarthropathy. [Journal Article]
- Med Sci Monit 2015.:2141-8.
BACKGROUNDGross deformity of the foot in Charcot neuroarthropathy can lead to foot collapse and subsequent ulceration, infection, amputation, or premature death. Total-contact casting (TCC) is a well-established treatment for neuropathic diabetic plantar foot ulcers. It was hypothesized that arthrodesis plus TCC may have advantages over TCC alone. This pilot study compared the effectiveness of arthrodesis plus TCC with TCC alone for the prevention, treatment, and recurrence of midfoot ulcerations associated with Charcot neuroarthropathy. MATERIAL AND
METHODSTwenty-one subjects with plantar ulcers associated with unilateral diabetic Charcot midfoot neuroarthropathy were randomly assigned to ADS or TCC groups. The ADS group underwent an extended medial column arthrodesis procedure and TCC; ulcers were sutured directly. The TCC group underwent TCC alone with dressing changes. All patients underwent nerve conduction studies and quantitative sensory testing at baseline and during follow-up (6 and 12 months). Healing time and ulcer relapse rate were evaluated.
RESULTSCompared with the TCC group, there were fewer lesions in the ADS group after treatment (P<0.05). Temperature testing and vibration perception threshold improved significantly after ADS (P<0.05). Although the number of patients positive for pinprick and light touch sensations increased after surgery, not all patients recovered these sensations. Healing time was not significantly different between the 2 groups (24.25±3.89 vs. 25.89±2.84 days, P>0.05). There was no ulcer recurrence after 12 months in the ADS group compared with 33.3% in the TCC group.
CONCLUSIONSAn extended medial column arthrodesis may partly improve sensory impairments and restore protective sensation in patients with Charcot neuroarthropathy.
- Homologous sense and antisense expression of a gene in Dunaliella tertiolecta. [JOURNAL ARTICLE]
- Planta 2015 Jul 23.
- Microsecond-resolved SDR-based cavity ring down ellipsometry. [Journal Article]
- Appl Opt 2015 Jun 20; 54(18):5861-5.
- A Unique Case of Common Peroneal Nerve Entrapment. [Journal Article]
- Orthopedics 2015 Jul 1; 38(7):e644-6.
- Histological Correlates of Penile Sexual Sensation: Does Circumcision Make a Difference? [Journal Article, Review]
- Sex Med 2015 Jun; 3(2):76-85.
- Functional and aesthetic outcomes of the fingertips after nail lengthening using the eponychial flap. [JOURNAL ARTICLE]
- J Plast Reconstr Aesthet Surg 2015 Jun 14.
- Gene/environment interactions in the pathogenesis of autoimmunity: New insights on the role of Toll-like receptors. [REVIEW, JOURNAL ARTICLE]
- Autoimmun Rev 2015 Jul 13.