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(naked DNA)
3,456 results
  • Studying Closed Hydrodynamic Models of "In Vivo" DNA Perfusion in Pig Liver for Gene Therapy Translation to Humans. [Journal Article]
  • PlosPLoS One 2016; 11(10):e0163898
  • Sendra L, Miguel A, … Aliño SF
  • CONCLUSIONS: Hydrofection of hAAT DNA to "in vivo" isolated pig liver mediates highly efficient gene delivery and protein expression in tissue. Both endovascular and surgically closed models mediate high tissue protein expression. Impairment of protein secretion to plasma is observed and might be species-related. This study reinforces the potential application of closed liver hydrofection for therapeutic purposes, provided protein secretion improves.
  • Detection of parvovirus B19 DNA in blood: Viruses or DNA remnants? [Journal Article]
  • JCJ Clin Virol 2016 Sep 13; 84:19-23
  • Molenaar-de Backer MW, Russcher A, … Zaaijer HL
  • CONCLUSIONS: Detection of B19V DNA in blood by PCR does not necessarily imply that B19V replication takes place and that infectious B19V virions are present. We propose that remnant B19V DNA strands can be released from tissues without active replication. This finding urges to reconsider an assumed role of B19V infection mainly based on B19V DNA detection in blood, a much debated subject in clinical syndromes such as myocarditis and arthritis.
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