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6,011 results
  • Octreotide use and safety in infants with hyperinsulinism. [Journal Article]
  • PDPharmacoepidemiol Drug Saf 2016 Dec 2
  • McMahon AW, Wharton GT, … De Leon DD
  • CONCLUSIONS: This study highlights potential risks in administering octreotide off-label. This study, like several other published studies, has highlighted NEC in a full-term infant treated with octreotide. It is important to study the efficacy and the safety of octreotide for hyperinsulinism. In the interim, it might be prudent to prescribe octreotide in CHI neonates only in the absence of other risk factors for NEC. Copyright © 2016 John Wiley & Sons, Ltd.
  • PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. [Journal Article]
  • LDLancet Diabetes Endocrinol 2016 Nov 28
  • Schmidt AF, Swerdlow DI, … Sattar N
  • CONCLUSIONS: PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, bodyweight, and waist-to-hip ratio, and an increased risk of type 2 diabetes. In trials of PCSK9 inhibitor drugs, investigators should carefully assess these safety outcomes and quantify the risks and benefits of PCSK9 inhibitor treatment, as was previously done for statins.
  • Propensity Score Weighting Compared to Matching in a Study of Dabigatran and Warfarin. [Journal Article]
  • DSDrug Saf 2016 Nov 29
  • Seeger JD, Bykov K, … Schneeweiss S
  • CONCLUSIONS: In this example, different applications of the same PS led to substantially different results, a finding that was particularly apparent with IPTW, and this was remedied by truncating extreme weights. If IPTW is used, information regarding the weights applied along with sensitivity analyses could avoid misrepresentation of study results, and would enhance their interpretation.
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