- Lack of an apparent role for endothelin-1 in the prolonged reduction in renal perfusion following severe unilateral ischemia-reperfusion injury in the mouse. [Journal Article]
- PRPhysiol Rep 2016; 4(21)
- Therapeutic approaches to block the progression from acute kidney injury to chronic kidney disease are currently lacking. Endothelin-1 (ET-1) is a powerful vasoconstrictor, induced by hypoxia, and pr...
Therapeutic approaches to block the progression from acute kidney injury to chronic kidney disease are currently lacking. Endothelin-1 (ET-1) is a powerful vasoconstrictor, induced by hypoxia, and previously implicated in renal ischemia-reperfusion (IR) injury. This study tested the hypothesis that blunting the vascular influence of ET-1, either through endothelin ETA receptor blockade (ABT-627) or vascular endothelial cell deletion of ET-1 (VEET KO), would improve recovery of renal perfusion and repair of injury following a severe ischemic insult in mice (45 min unilateral renal ischemia). Male C57Bl/6 mice receiving vehicle or ABT-627 commencing 2 days prior to surgery, and VEET KO mice and wild-type littermates (WT) underwent 45 min unilateral renal IR surgery followed by 28 days recovery. Renal blood velocity was measured by pulsed-wave Doppler ultrasound before and after surgery. Renal blood velocity was not significantly different between pairs of groups before surgery. Unilateral IR induced a marked reduction in renal blood velocity of the IR kidney at 24 h postsurgery in all groups, which partially recovered but remained below baseline at 28 days post-IR. Despite the lack of effect on renal blood velocity, ETA receptor blockade significantly attenuated the atrophy of the post-IR kidney, whereas this was not significantly affected by lack of endothelial ET-1 expression. These data suggest that although blockade of the ETA receptor is mildly beneficial in preserving renal mass following a severe ischemic insult, this protective effect does not appear to involve improved recovery of renal perfusion.
- Lung and cardiac ultrasound for hemodynamic monitoring of patients with severe pre-eclampsia. [Journal Article]
- UOUltrasound Obstet Gynecol 2016 Oct 13
- CONCLUSIONS: Severe PE is associated with an increase in extravascular lung water, which could in part be caused by disturbed diastolic left ventricular function. Excess lung water can be identified by lung ultrasound assessment in women with severe PE before the appearance of clinical signs. Only a small proportion of these women are fluid responsive. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
- Myocardial Function Pre- and Post-Fetal Endoscopic Tracheal Occlusion (FETO) in Fetuses with Left-Sided Moderate to Severe Congenital Diaphragmatic Hernia. [Journal Article]
- UMUltraschall Med 2016 Sep 14
- Purpose: To evaluate pre- and postprocedural myocardial function in fetuses with moderate to severe congenital diaphragmatic hernia (CDH) who underwent FETO to improve survival and to reduce morbidit...
Purpose: To evaluate pre- and postprocedural myocardial function in fetuses with moderate to severe congenital diaphragmatic hernia (CDH) who underwent FETO to improve survival and to reduce morbidity and to compare these data with fetuses and CDH not undergoing FETO and normal controls. Materials and Methods: 8 fetuses with isolated left-sided CDH were included and underwent FETO at our center between 2012 and 2013. Prior to and after the operation, myocardial function was assessed by measuring the mitral annular plane systolic excursion (MAPSE), the tricuspid annular plane systolic excursion (TAPSE), Tei index, isovolumetric contraction time (ICT), ejection time (ET), isovolumetric relaxation time (IRT) for the left ventricle in PW Doppler ultrasound as well as ICT, ET, IRT and Tei index in pulsed wave tissue Doppler imaging (PW-TDI) for the left and right ventricle. The E-, A-, E'- and A'-wave peak velocity and the systolic downward motion (S') were measured for both ventricles and the E/A, E/E' and E'/A' ratios were calculated. Results: were compared to fetuses with CDH not undergoing FETO and to gestational age-matched healthy controls.
- Magnetic Nanoparticle-Mediated Targeting of Cell Therapy Reduces In-Stent Stenosis in Injured Arteries. [Journal Article]
- ANACS Nano 2016 Sep 19
- Although drug-eluting stents have dramatically reduced the recurrence of restenosis after vascular interventions, the nonselective antiproliferative drugs released from these devices significantly de...
Although drug-eluting stents have dramatically reduced the recurrence of restenosis after vascular interventions, the nonselective antiproliferative drugs released from these devices significantly delay reendothelialization and vascular healing, increasing the risk of short- and long-term stent failure. Efficient repopulation of endothelial cells in the vessel wall following injury may limit complications, such as thrombosis, neoatherosclerosis, and restenosis, through reconstitution of a luminal barrier and cellular secretion of paracrine factors. We assessed the potential of magnetically mediated delivery of endothelial cells (ECs) to inhibit in-stent stenosis induced by mechanical injury in a rat carotid artery stent angioplasty model. ECs loaded with biodegradable superparamagnetic nanoparticles (MNPs) were administered at the distal end of the stented artery and localized to the stent using a brief exposure to a uniform magnetic field. After two months, magnetic localization of ECs demonstrated significant protection from stenosis at the distal part of the stent in the cell therapy group compared to both the proximal part of stent in the cell therapy group and the control (stented, nontreated) group: 1.7-fold (p < 0.001) less reduction in lumen diameter as measured by B-mode and color Doppler ultrasound, 2.3-fold (p < 0.001) less reduction in the ratios of peak systolic velocities as measured by pulsed wave Doppler ultrasound, and 2.1-fold (p < 0.001) attenuation of stenosis as determined through end point morphometric analysis. The study thus demonstrates that magnetically assisted delivery of ECs is a promising strategy for prevention of vessel lumen narrowing after stent angioplasty procedure.
- The Inter-rater Reliability of Echocardiographic Diastolic Function Evaluation Among Emergency Physician Sonographers. [Journal Article]
- JEJ Emerg Med 2016; 51(4):411-417
- CONCLUSIONS: EP sonographers obtained similar Doppler measurements for diastolic function evaluation with very good inter-rater reliability for the assessment of overall diastolic function.
- Effects of intravenous bolus injection of nicorandil on renal artery flow velocity assessed by color Doppler ultrasound. [Journal Article]
- JCJ Cardiol 2016 Sep 06
- CONCLUSIONS: Intravenous nicorandil increased renal artery blood flow velocity in comparison with nitroglycerin. Nicorandil has a significant effect on renal hemodynamics.
- Measured acoustic intensities for clinical diagnostic ultrasound transducers and correlation to the Thermal Index. [Journal Article]
- UOUltrasound Obstet Gynecol 2016 Sep 08
- CONCLUSIONS: The TIB is a poor predictor for spatial-peak temporal-average intensity, spatial-peak pulse-average acoustic intensity and potential bioeffects from clinical diagnostic ultrasound scanners.
- [EVALUATION OF ARTERIAL STIFFNESS AND POSSIBILITY TO PREDICT CAROTID ATHEROSCLEROSIS IN PATIENTS WITH ESSENTIAL HYPERTENSION BASED ON AN OUTPATIENT FACILITY]. [Journal Article]
- KMKlin Med (Mosk) 2016; 94(3):211-7
- To estimate the possibility of predicting the presence and severity of coronary atherosclerosis from arterial stiffness characteristics and augmentation index (AIx) in patients with essential hyperte...
To estimate the possibility of predicting the presence and severity of coronary atherosclerosis from arterial stiffness characteristics and augmentation index (AIx) in patients with essential hypertension (EH) obtained under outpatient conditions.
- Pulsed-wave Doppler ultrasonographic evaluation of hepatic vein in dogs with tricuspid regurgitation. [Journal Article]
- JVJ Vet Sci 2016 Aug 10
- This study was performed to identify the relationship between the hepatic vein (HV) measurements, including flow velocity and waveform, performed with pulsed-wave (PW) Doppler ultrasonography and sev...
This study was performed to identify the relationship between the hepatic vein (HV) measurements, including flow velocity and waveform, performed with pulsed-wave (PW) Doppler ultrasonography and severity of tricuspid regurgitation (TR) in dogs. The study included 22 dogs with TR and 7 healthy dogs. The TR group was subdivided into 3 groups according to the TR jet profile in echocardiographic examination. The hepatic venous waveform was obtained and classified into 3 types. The measurements of HV, including the maximal velocities of the atrial systolic (A), systolic (S), end ventricular systolic (V), and diastolic (D) waves and the ratio of the S- and D- wave velocities (S:D ratio), were acquired. TR severity was significantly correlated with the S- (r= -0.380, p= 0.042), D- (r = 0.468, p = 0.011) wave velocities, and S:D ratio (r= -0.747, p< 0.001). In receiver operating characteristic curve analysis, the highest sensitivity and specificity were found for the S:D ratio (89% and 75%, respectively) at a threshold of 0.97, with excellent accuracy (AUC= 0.911, p< 0.001). In conclusion, PW Doppler ultrasonographic examination of the HV can be used for identifying the presence of clinically significant TR and classifying TR severity in dogs.
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- Vein of Galen Aneurysmal malformation (VGAM) in the fetus. A retrospective analysis of perinatal prognostic indicators in a two-center series of 49 cases. [Journal Article]
- UOUltrasound Obstet Gynecol 2016 Aug 12
- CONCLUSIONS: Major brain lesions, tricuspid regurgitation and, to a lesser extent an MRV ≥ 20000 mm3 are the only prenatal variables associated with poor outcome in fetal VGAM. Prenatal multidisciplinary counselling should be based on the results of these variables.