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  • Tc-99m-ECD SPECT as the measure for therapeutic response in patients with cobalamin deficiency: Two case reports. [Journal Article]
  • Medicine (Baltimore) 2016; 95(39):e4851M
  • Tu MC, Lo CP, Chen CY
  • CONCLUSIONS: Given that the ACC integrates the limbic system and frontosubcortical circuits and the PFC governs executive function, the extent and severity of hypofrontality may be responsible for the worse prognosis. Our Tc-99m-ECD SPECT observations revealed that the negative impact on cerebral metabolic tone is relevant to the severity of Cbl deficiency, and the functional integrity of the ACC and PFC is highly associated with the preservation of global cognitive function in our cases with Cbl deficiency.
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