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(xylometazoline hydrochloride)
279 results
  • Nasal decongestants in monotherapy for the common cold. [Review]
  • CDCochrane Database Syst Rev 2016 Oct 17; 10:CD009612
  • Deckx L, De Sutter AI, … van Driel ML
  • CONCLUSIONS: We were unable to draw conclusions on the effectiveness of single-dose nasal decongestants due to the limited evidence available. For multiple doses of nasal decongestants, the current evidence suggests that these may have a small positive effect on subjective measures of nasal congestion in adults with the common cold. However, the clinical relevance of this small effect is unknown and there is insufficient good-quality evidence to draw any firm conclusions. Due to the small number of studies that used a topical nasal decongestant, we were also unable to draw conclusions on the effectiveness of oral versus topical decongestants. Nasal decongestants do not seem to increase the risk of adverse events in adults in the short term. The effectiveness and safety of nasal decongestants in children and the clinical relevance of their small effect in adults is yet to be determined.
  • Impact of xylomethazoline on eustachian tube function in healthy participants. [Journal Article]
  • ONOtol Neurotol 2015; 36(5):769-75
  • Meyer MF, Mikolajczak S, … Beutner D
  • CONCLUSIONS: We conclude that xylomethazoline might only have a minor effect during active and passive middle ear pressure equalization. Larger cohorts and targeted application of decongestants should be tested to confirm these preliminary data and to find new evidence on the effects of decongestants.
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