Contraindicated in:

• Active internal bleeding;

• History of cerebrovascular accident;

• Recent (within 2 mo) intracranial or intraspinal surgery or trauma;

• Intracranial neoplasm, arteriovenous malformation, or aneurysm;

• Severe uncontrolled hypertension;

• Known bleeding diathesis;

• Hypersensitivity.

• Recent major surgery, trauma, GI, or GU bleeding;

• Cerebrovacular disease;

• Hypertension (BP ≥180 mm Hg and or diastolic ≥110 mm Hg);

• Presence or high likelihood of left heart thrombus;

• Subacute bacterial endocarditis or acute pericarditis;

• Hemostatic defect especially those associated with severe hepatic or renal disease;

• Severe hepatic dysfunction;

• Geriatric patients (increased risk of intracranial bleeding);

• Hemorrhagic ophthalmic conditions;

• Septic phlebitis or occulded AV cannula at infected site;

• Concurrent warfarin therapy or recent therapy with glycoptrotein (GP) IIb/IIIa inhibitors (abciximab, eptifibatide, tirofiban);

• Pregnancy, lactation, or children (safety not established).