Active internal bleeding;
History of cerebrovascular accident;
Recent (within 2 mo) intracranial or intraspinal surgery or trauma;
Intracranial neoplasm, arteriovenous malformation, or aneurysm;
Severe uncontrolled hypertension;
Known bleeding diathesis;
Hypersensitivity.Use Cautiously in:
Recent major surgery, trauma, GI, or GU bleeding;
Hypertension (BP ≥180 mm Hg and or diastolic ≥110 mm Hg);
Presence or high likelihood of left heart thrombus;
Subacute bacterial endocarditis or acute pericarditis;
Hemostatic defect especially those associated with severe hepatic or renal disease;
Severe hepatic dysfunction;
Geriatric patients (increased risk of intracranial bleeding);
Hemorrhagic ophthalmic conditions;
Septic phlebitis or occulded AV cannula at infected site;
Concurrent warfarin therapy or recent therapy with glycoptrotein (GP) IIb/IIIa inhibitors (abciximab, eptifibatide, tirofiban);
Pregnancy, lactation, or children (safety not established).
tenecteplase has been found in Davis's Drug Guide
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