Binds to bacterial cell wall membrane, causing cell death.
Bactericidal action against susceptible bacteria.
Similar to that of first-generation cephalosporins but has increased activity against several other gram-negative pathogens including:
» Haemophilus influenzae ,
» Escherichia coli ,
» Klebsiella pneumoniae ,
» Neisseria gonorrhoeae (including penicillinase-producing strains),
» Proteus ,
» Moraxella catarrhalis .
Also has modest activity against Bacteroides fragilis .
Not active against methicillin-resistant staphylococci or enterococci.
cefamandole has been found in Davis's Drug Guide
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