See pharmacokinetic sections in hydralazine and isosorbide dinitrate monographs of Davis's Drug Guide for Nurses for more information.Absorption: Hydralazine1026% absorbed in HF patients, absorption can be saturated leading to large increases in absorption with higher doses; isosorbide dinitratevariable absorbed (1090%) reflecting first-pass hepatic metabolism.
Distribution: Hydralazinewidely distributed, crosses the placenta, minimal amounts in breast milk; isosorbide dinitrateaccumulates in muscle and venous wall.
Metabolism and Excretion: Hydralazinemostly metabolized by GI mucosa and liver; isosorbide dinitrateundergoes extensive first-pass metabolism in the liver mostly metabolized by the liver, some metabolites are vasodilators.
Half-life: Hydralazine4 hr; isosorbide dinitrate2 hr.
TIME/ACTION PROFILE ( effect on BP)
|hydralazine||45 min ||2 hr||24 hr|
|isosorbide||1540 min||unknown||4 hr|
hydralazine/isosorbide dinitrate has been found in Davis's Drug Guide
If you are a registered user, please login below.
If not, learn more about gaining full access.
- Try and Buy
- Nursing Central puts five fully integrated references at your fingertips on mobile devices and the web. See how Nursing Central works by clicking the sample entries below or purchase a subscription for the web and your mobile device.
View these free topics online now.