Davis's Drug Guide
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calcitriol

Route/Dosage

Hypocalcemia During Dialysis

PO: (Adults) 0.25 mcg/day or every other day; if needed, may ↑ by 0.25 mcg/day at 4–8 wk intervals (typical dosage = 0.5–1 mcg/day).

PO: (Children <10 kg): 0.05 mcg every other day; 10–20 kg: 0.1–0.15 mcg daily; >20 kg 0.25 mcg daily.

IV: (Adults) 0.5 mcg (0.01 mcg/kg) 3 times weekly during dialysis. May be increased by 0.25–0.5 mcg/dose at 2- to 4-wk intervals (typical maintenance dose = 0.5–3 mcg 3 times weekly (0.01–0.05 mcg/kg 3 times weekly).

IV: Children 0.01–0.05 mcg/kg 3 times weekly during dialysis.

Hypoparathyroidism

PO: (Adults and Children ≥6 yr): 0.25 mcg/day initially; if needed, may ↑ dose by 0.25 mcg/day at 2–4 wk intervals (typical dosage = 0.5–2 mcg/day).

PO: (Children ≤5 yr): <1 yr-0.04–0.08 mcg/kg/day1–5 yr-0.25–0.75 mcg/day.

Predialysis Patients

PO: (Adults and Children ≥3 yr): 0.25 mcg/day; if needed, may ↑ dosage up to 0.5 mcg/day.

Rickets

PO: (Adults and Children) Vitamin D-dependent-1 mcg daily; Vitamin D-resistant-Inital 0.015–0.02 mcg/kg daily; range: 0.03–0.06 mcg/kg daily; maximum dose: 2 mcg daily.

Hypocalcemia in Premature Infants

PO: Neonates 1 mcg daily for first 5 days of life.

IV: Neonates Tetany-0.05 mcg/kg daily for 5–12 days.

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