Route/Dosage
PO: (Adults) HER2 positive metastatic breast cancer–1250 mg once daily for 21 days; Hormone receptor positive, HER2 positive metastatic breast cancer–1500 mg once daily; Concurrent use of strong CYP3A4 inhibitor–↓ dose to 500 mg once daily; Concurrent use of strong CYP3A4 inducer– HER2 positive metastatic breast cancer: Gradually titrate dose from 1250 mg once daily up to 4500 mg once daily as tolerated; Hormone receptor positive, HER2 positive metastatic breast cancer: Gradually titrate dose from 1500 mg once daily up to 5500 mg once daily as tolerated.
Hepatic Impairment
PO: (Adults) Severe hepatic impairment–HER2 positive metastatic breast cancer: 750 mg/day; Hormone receptor positive, HER2 positive metastatic breast cancer: 1000 mg/day.
lapatinib has been found in Davis's Drug Guide
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