Davis's Drug Guide
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potassium phosphate

Implementation

  • High Alert: Too rapid or bolus IV administration of potassium has resulted in fatalities. See IV administration guidelines below.
  • PO: Powder packets should be dissolved in 75 mL of water. Allow mixture to stand for 2–5 min to ensure that it is fully dissolved.
    • Medication should be administered with meals to minimize gastric irritation and risk of diarrhea.
    • Do not administer simultaneously with antacids containing aluminum, magnesium, or calcium.
  • IV: High Alert: Administer only in dilute concentration. Common component of total parenteral nutrition. Do not administer IM.
  • Continuous InfusionDiluent: Dilute with 0.45% NaCl, 0.9% NaCl, D5W, D10W, D5/0.45% NaCl, D5/0.9% NaCl, or TPN solutions Doses usually placed in 250–500 mL.
  • Rate: High Alert: Infuse as a continuous infusion at a slow rate (over 4–6 hr) maximum: 0.06 mmol/kg/hr.
  • Concentration Peripheral line maximum: 0.05 mmol/mL; Central line maximum: 0.12 mmol/mL.
  • Y-Site Compatibility
    • ciprofloxacin
    • diltiazem
    • enalaprilat
    • esmolol
    • famotidine
    • labetalol
  • Additive Compatibility
    • magnesium sulfate
    • metoclopramide
    • verapamil
  • Solution Incompatibility
    • Ringer's or lactated Ringer's injection
    • D10/0.9% NaCl
    • D5/LR

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