Contraindicated in:

• Previous hypersensitivity to penicillins (cross-sensitivity exists with cephalosporins and other beta-lactam antibiotics);

• Hypersensitivity to procaine or benzathine (procaine and benzathine preparations only);

• Some products may contain tartrazine and should be avoided in patients with known hypersensitivity.

• Severe renal insufficiency (dosage reduction recommended);

• OB: Although safety not established, has been used safely;

• Lactation: Safety not established;

• Geri: Consider decreased body mass, age-related decrease in renal/hepatic/cardiac function, intercurrent diseases and drug therapy.