Additive CV and CNS side effects with adrenergics (sympathomimetic) .
May ↓ the therapeutic effect of lithium and phenytoin .
Smoking, barbiturates , carbamazepine , phenytoin , nevirapine and rifampin may ↑ metabolism and may decrease effectiveness.
Erythromycin , beta blockers , clarithromycin , calcium channel blockerscimetidine , hormonal contraceptives , disulfiram , doxycycline , estrogens , fluvoxamine , isoniazid , ketoconazole , mexiletine , nefazodone , protease inhibitors , quinidine , some fluoroquinolones , and large doses of allopurinol ↓ metabolism and may lead to toxicity.Drug-Natural Products
Caffeine-containing herbs ( cola nut , guarana , mate , tea, coffee) may ↑ serum levels and risk of CNS and CV side effects.
↓ serum levels and effectiveness with St. John's wort .Drug-Food
Excessive regular intake of charcoal-broiled foods may ↓ effectiveness.
theophylline has been found in Davis's Drug Guide
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