Absorption: Splits into ranitidine and bismuth in the GI tract; bismuth is not absorbed.
Distribution: All agents enter breast milk and cerebrospinal fluid.
Metabolism and Excretion: Ranitidine–metabolized by the liver, mostly on first pass; 30% excreted unchanged by the kidneys after PO administration, 70–80% after parenteral administration.
Half-life: Ranitidine–1.7–3 hr (all are increased in renal impairment).
|PO||unknown||1–3 hr||8–12 hr|
ranitidine bismuth citrate has been found in Davis's Drug Guide
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