• Explain purpose, risks and benefits of therapy to patient. Risks or long term therapy are unknown.

• Instruct patient to avoid taking eltrombopag within 4 hr of foods, mineral supplements, and antacids containing iron, calcium, aluminum, magnesium, zinc, and selenium.

• Advise patients to avoid activities that may increase risk of bleeding.

• Instruct patient to notify health care professional if symptoms of liver problems (yellowing of skin or whites of eyes, unusual darkening of urine, unusual tiredness, pain in right upper stomach) occur.

• Advise female patients to notify health care professional promptly if pregnancy is planned or suspected or if breastfeeding. A pregnancy registry has been established to collect information about eltrombopag effects during pregnancy. Enrollment is by calling 1-888-825-5249.

• Emphasize the importance of routine lab tests to determine effectiveness and monitor for side effects.