Carbidopa/Levodopa

PO: (Adults) 25 mg carbidopa/100 mg levodopa 3 times daily; may be ↑ every 1–2 days until desired effect is achieved (max = 8 tablets of 25 mg carbidopa/100 mg levodopa/day).

Carbidopa/Levodopa Extended-Release

PO: (Adults) Patients not currently receiving levodopa–50 mg carbidopa/200 mg levodopa twice daily (minimum of 6 hr apart) initially. Conversion from standard carbidopa/levodopa–initiate therapy with at least 10% more levodopa content/day (may need up to 30% more) given at 4–8 hr intervals while awake. Allow 3 days between dosage changes; some patients may require larger doses and shorter dosing intervals.