Used in the treatment of various forms of endogenous depression, often in conjunction with psychotherapy. Other uses include:

» Treatment of anxiety (doxepin, fluoxetine, paroxetine, sertraline, venlafaxine)

» Enuresis (imipramine)

» Chronic pain syndromes (amitriptyline, doxepin, imipramine, nortriptyline)

» Smoking cessation (bupropion)

» Bulimia (fluoxetine)

» Obsessive-compulsive disorder (fluoxetine, fluvoxamine, paroxetine, sertraline)

» Social anxiety disorder (paroxetine, sertraline).