Used in replacement doses (20 mg of hydrocortisone or equivalent) systemically to treat adrenocortical insufficiency. Larger doses are usually used for their antiinflammatory, immunosuppressive, or antineoplastic activity. Used adjunctively in many other situations, including hypercalcemia and autoimmune diseases. Topical corticosteroids are used in a variety of inflammatory and allergic conditions. Inhalant corticosteroids are used in the chronic management of reversible airway disease (asthma); intranasal and ophthalmic corticosteroids are used in the management of chronic allergic and inflammatory conditions.