Contraindicated in:

• Hypersensitivity to abciximab or murine (mouse) protein;

• Active internal bleeding;

• Recent significant GI or GU bleeding (within 6 wk);

• History of CVA (within 2 yr) or CVA with neurologic sequelae;

• History of bleeding disorder;

• Recent (within 7 days) oral anticoagulant therapy (PT ≥1.2 times control);

• Platelet count <100,000 cells/mm³;

• Recent trauma or major surgery (within 6 wk);

• Intracranial neoplasm;

• Aneurysm or AV malformation;

• Severe uncontrolled hypertension;

• History of vasculitis;

• Concurrent use of another parenteral GP IIb/IIIa inhibitor;

• Recent or concurrent dextran therapy.

• Patients weighing <75 kg or >65 yr (increased risk of bleeding);

• History of previous GI pathology;

• Concurrent thrombolytic or heparin therapy;

• PCI within 12 hr of onset of MI symptoms or PCI procedure lasting >70 min;

• OB: Lactation: Pedi: Safety not established.